223251-16-9

Basic information

• Product Name: (4-(2-(azepan-1-yl)ethoxy)phenyl)Methanol
• Synonyms: (4-(2-(azepan-1-yl)ethoxy)phenyl)Methanol;BenzeneMethanol, 4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]-;4-[2-(Hexahydro-1H-azepin-1-yl)ethoxy]- benzeneMethanol;4-(2-Azepan-1-ylethoxy)benzyl alcohol
• CAS NO: 223251-16-9
• Molecular Formula: C₁₅H₂₃NO₂
• Molecular Weight: 249.34862
• EINECS: 1592732-453-0
• Mol File: 223251-16-9.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 403.995°C at 760 mmHg
• Flash Point: 198.129°C
• Appearance: /
• Density: 1.061g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.536
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.52±0.10(Predicted)
• CAS DataBase Reference: (4-(2-(azepan-1-yl)ethoxy)phenyl)Methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (4-(2-(azepan-1-yl)ethoxy)phenyl)Methanol(223251-16-9)
• EPA Substance Registry System: (4-(2-(azepan-1-yl)ethoxy)phenyl)Methanol(223251-16-9)

Safety Data

• Hazardous Substances Data: 223251-16-9(Hazardous Substances Data)

Usage

General Description

(4-(2-(azepan-1-yl)ethoxy)phenyl)Methanol is a chemical compound with the molecular formula C17H25NO2. It is a white to off-white solid at room temperature and is mainly used in the research and development of pharmaceuticals. The compound is classified as an alcohol, with a hydroxyl group attached to a phenyl ring that is further connected to an azepan-1-yl ethoxy group. This chemical may have potential applications in the pharmaceutical industry, particularly in the development of new drugs for the treatment of various medical conditions. However, further research and testing are needed to fully understand its properties and potential uses.

InChI:InChI=1/C15H23NO2/c17-13-14-5-7-15(8-6-14)18-12-11-16-9-3-1-2-4-10-16/h5-8,17H,1-4,9-13H2

Upstream product

• 223251-09-0 4-[2-(azepan-1-yl)ethoxy]benzaldehyde 
• 767630-86-4 4-(2-oxo-2-hexamethyleneimino-ethoxy)-benzaldehyde 
• 623-05-2 (4-hydroxyphenyl)methanol 
• 26487-67-2 1-(2-chloroethyl)azepane hydrochloride 
• 2205-31-4 1-(2-chloroethyl)-1H-hexahydroazepine 
• 111-49-9 hexamethylene imine 
• 123-08-0 4-hydroxy-benzaldehyde 
• 38459-72-2 (4-(2-bromoethoxy)phenyl)methan-1-ol 
• 52191-15-8 4-(2-bromoethyloxy)benzaldehyde 

Downstream Products

• 198480-21-6 5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-1H-indole 
• 198481-32-2 bazedoxifene 
• 198481-33-3 bazedoxifene acetate 
• 223251-25-0 1-{2-[4-(chloromethyl)phenoxy]ethyl}hexahydro-1H-azepine hydrochloride 
• 1266685-11-3 1-[4-(2-azepan-1-yl-ethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol mesylate 
• 1266685-12-4 1-[4-(2-azepan-1-yl-ethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol propionate 
• 1335047-86-3 1-[4-[2-(azepan-1-yl)ethoxy]benzyl]naphthalen-2-ol 
• 328933-65-9 (4-(2-(azepan-1-yl)ethyl)phenyl)methanol hydrochloride 
• 859392-95-3 10-[4-(2-azepan-1-yl-ethoxy)-benzyl]-3,7-dimethoxy-10H-benzo[4,5]thieno[3,2-b]indole 
• 859392-93-1 10-[4-(2-azepan-1-yl-ethoxy)-benzyl]-7-methoxy-10H-benzo[4,5]thieno[3,2-b]indole 
• 212771-30-7 1-[2-(4-chloromethylphenoxy)ethyl]perhydroazepin 

Relevant articles and documents

Compound and preparation method and application thereof

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Preparation method of 1-(2-(4-(chloromethyl)phenoxy)ethyl)azacycloheptane hydrochloride

A preparation method of 1-(2-(4-(chloromethyl)phenoxy)ethyl)azacycloheptane hydrochloride comprises the steps of alkylation, substitution, reduction and chlorination. The preparation method for industrially producing the1-(2-(4-(chloromethyl)phenoxy)ethyl)azacycloheptane hydrochloride allows the final product to be produced from cycloheximide as raw material through alkylation, substitution, reduction and chlorination, the total yield of the four steps reaches about 70%, and the purity is 99%. The method also has the advantages of easiness in obtaining of the reaction raw material, mild conditions, simplicity in treatment, and high yield, and is a method suitable for industrial production.

SELECTIVE ESTROGEN RECEPTOR MODULATORS

The invention provides compounds of Formula (I) : wherein R1 is hydrogen, OH, halo, -CN, -NO2, -N=0, -NHOQ2, -OQ2, -SOQ2, -SO2Q2, -SON(Q2)2, - SO2N(Q2)2, -N(Q2)2, -C(O)OQ2, -C(O)Q2, -C(O)N(Q2)2, -C(=NQ2)NQ2, -NQ2C(=NQ2)NQ2, - C(O)N(Q2)(OQ2), -N(Q2)C(O)-Q2, -N(Q2)C(O)N(Q2)2, -N(Q2)C(O)O-Q2, -N(Q2)SO2Q2, -N(Q2)SOQ2, aliphatic, alkoxy, cycloaliphatic, aryl, arylalkyl, heterocyclic, or heteroaryl ring, each aliphatic, alkoxy, cycloaliphatic, aryl, arylalkyl, heterocyclic, and heteroaryl ring optionally including 1-3 substituents independently selected Q3; R2 and R3 are each independently hydrogen, OH, oxo, aliphatic, cycloaliphatic, heterocycloaliphatic, aryl, or heteroaryl, optionally substituted with 1-3 of Q1 or Q2; X is a branched or straight C1-12 aliphatic chain wherein up to two carbon units are optionally and independently replaced by -C(Q1)2-, -C(Q2)2-, CHQ1, CHQ2-, -CO-, -CS-, -CONQ2, -CO2-, -OCO-, -NQ2-, -NQ2CO2-, - O-, -NQ2CONQ2-, -OCONQ2-, -NQ2CO-, -S-, -SO-, -SO2-, -SO2NQ2-, -NQ2SO2-, or -NQ2SO2NQ2-; G and G1 are each independently a branched or straight C1-2 aliphatic chain, or heterocycloalkyl, wherein up to two carbon units are optionally and independently replaced by -C(Q1)2-, -C(Q2)2-, CHQ1, CHQ2-, -CO-, - CS-, -CONQ2, -CO2-, -OCO-, -NQ2-, -NQ2CO2-, -O-, -NQ2CONQ2-, -OCONQ2-, -NQ2CO-, -S-, -SO-, - SO2-, -SO2NQ2-, -NQ2SO2-, or -NQ2SO2NQ2-, and pharmaceutically acceptable salts, solvates or prodaigs thereof, as well as methods of treating estrogen receptor mediated diseases and disorders using the compounds of Formula (I).