223251-25-0Relevant articles and documents
Compound and preparation method and application thereof
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, (2020/12/15)
The invention relates to the field of medicinal chemistry and pharmacotherapeutics, in particular to a bazedoxifene analog compound and a preparation method thereof, application of the bazedoxifene analog compound in a GP130 small molecule inhibitor and t
Preparation method of 1-(2-(4-(chloromethyl)phenoxy)ethyl)azacycloheptane hydrochloride
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, (2017/12/27)
A preparation method of 1-(2-(4-(chloromethyl)phenoxy)ethyl)azacycloheptane hydrochloride comprises the steps of alkylation, substitution, reduction and chlorination. The preparation method for industrially producing the1-(2-(4-(chloromethyl)phenoxy)ethyl)azacycloheptane hydrochloride allows the final product to be produced from cycloheximide as raw material through alkylation, substitution, reduction and chlorination, the total yield of the four steps reaches about 70%, and the purity is 99%. The method also has the advantages of easiness in obtaining of the reaction raw material, mild conditions, simplicity in treatment, and high yield, and is a method suitable for industrial production.
PREPARATION OF BAZEDOXIFENE AND ITS SALTS
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, (2011/04/13)
Processes for preparing bazedoxifene and its pharmaceutically acceptable salts, substantially free from process related impurities and process intermediates.