22379-62-0Relevant articles and documents
Nonpolar solvent a key for highly regioselective SNAr reaction in the case of 2,4-difluoronitrobenzene
Sythana, Suresh Kumar,Naramreddy, Surendra R.,Kavitake, Santosh,Kumar,Bhagat, Pundlik R.
, p. 912 - 918 (2014/08/05)
A practical and highly regioselective aromatic nucleophilic substitution reaction for the substrate 2,4-difluoronitrobenzene is demonstrated with various O/S/N-nucleophiles. Solvent screens substantiate the role of a nonpolar solvent in ortho-selective nucleophilic substitution through a six-membered polar transition state.