2273-93-0

Basic information

• Product Name: 2,6-Dichloro-7-methylpurine
• Synonyms: 2,6-Dichloro-7-methyl-7h-purine ,98%;7H-Purine, 2,6-dichloro-7-methyl-;2,6-dichloro-7-methyl-purin;2,6-DICHLORO-7-METHYLPURINE;2,6-DICHLORO-7-METHYL-7H-PURINE;2,6-DICHLORO-7-METHYLPURINE 97% (HPLC);2,6-DICHLORO-7-METHYLPURINE (2,6DCl7MeP)
• CAS NO: 2273-93-0
• Molecular Formula: C₆H₄Cl₂N₄
• Molecular Weight: 203.03
• Mol File: 2273-93-0.mol
• Article Data: 16

Chemical Properties

• Melting Point: 195.5-196 °C
• Boiling Point: 307.247 °C at 760 mmHg
• Flash Point: 139.6 °C
• Appearance: Off-white crystalline powder
• Density: 1.76 g/cm³
• Vapor Pressure: 0.000733mmHg at 25°C
• Refractive Index: 1.76
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -2.04±0.30(Predicted)
• CAS DataBase Reference: 2,6-Dichloro-7-methylpurine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Dichloro-7-methylpurine(2273-93-0)
• EPA Substance Registry System: 2,6-Dichloro-7-methylpurine(2273-93-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 2273-93-0(Hazardous Substances Data)

Usage

Uses

2,6-DICHLORO-7-METHYLPURINE is used in the preparation and discover of novel mTOR INHIBITORS.

InChI:InChI=1/C6H4Cl2N4/c1-12-2-9-5-3(12)4(7)10-6(8)11-5/h2H,1H3

Upstream product

• 83-67-0 theobromine / 
• 552-62-5 7-methylxanthine 
• 10025-87-3 trichlorophosphate 
• 5451-40-1 2,6-dichloro-7H-purine 
• 74-88-4 methyl iodide 
• 74-87-3 methylene chloride 
• 5451-40-1 2,6 dichloropurine 

Downstream Products

• 97184-71-9 2-chloro-6-methoxy-7-methylpurine 
• 857172-63-5 2-chloro-6-diethylamine-7-methylpurine 
• 33403-02-0 7-methyl-2,6-dithioxo-1,2,3,6-tetrahydropurine 
• 5444-30-4 2-chloro-N6-methyl-N7-methyladenine 
• 5453-10-1 2-chloro-6-amino-7-methylpurine 
• 18346-04-8 7-methylpurine 
• 552-62-5 7-methylxanthine 
• 7329-82-0 2,6-Diamino-7-methyl-purin 
• 16017-76-8 2-chloro-7-methyl-6-oxo-1,6-dihydropurine 
• 53050-28-5 2-chloro-7-methyl-6-purinethione 
• 97202-78-3 2-chloro-6-ethoxy-7-methylpurine 
• 16404-16-3 2,6,8-trichloro-7-methylpurine 
• 52093-82-0 7-methyl-3,7-dihydro-purin-2-one 
• 17587-95-0 2-chloro-N⁴-methylpyrimidine-4,5-diamine 

Relevant articles and documents

Tetrabutylammonium fluoride-assisted rapid N9-alkylation on purine ring: Application to combinatorial reactions in microtiter plates for the discovery of potent sulfotransferase inhibitors in situ

Tremendous efforts have been invested in the synthesis of purine libraries due to their importance in targeting various enzymes involved in different diseases and cellular processes. The synthesis of N9-alkylated purine scaffolds relied mostly

HYPOXANTHINE COMPOUND

PROBLEM TO BE SOLVED: To provide a novel compound having an inhibitory action of prolyl hydroxylase (PHDs) and useful as a therapeutic agent of an inflammatory bowel disease such as ulcerative colitis. SOLUTION: The present invention relates to a hypoxanthine compound represented by the following formula (I) or a pharmacologically acceptable salt thereof. The compound of the present invention or its pharmaceutically acceptable salt has an inhibitory effect of prolyl hydroxylase and is useful as a therapeutic agent for inflammatory bowel disease such as ulcerative colitis. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

Direct, Regioselective N-Alkylation of 1,3-Azoles

Regioselective N-alkylation of 1,3-azoles is a valuable transformation. Organomagnesium reagents were discovered to be competent bases to affect regioselective alkylation of various 1,3-azoles. Counterintuitively, substitution selectively occurred at the more sterically hindered nitrogen atom. Numerous examples are provided, on varying 1,3-azole scaffolds, with yields ranging from 25 to 95%.