229648-45-7

Basic information

• Product Name: Methyl 4-(isopropylcarbaMoyl)benzoate
• Synonyms: Methyl 4-(isopropylcarbaMoyl)benzoate;methyl 4-[(isopropylamino)carbonyl]benzoate
• CAS NO: 229648-45-7
• Molecular Formula: C₁₂H₁₅NO₃
• Molecular Weight: 221.2524
• Mol File: 229648-45-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Methyl 4-(isopropylcarbaMoyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-(isopropylcarbaMoyl)benzoate(229648-45-7)
• EPA Substance Registry System: Methyl 4-(isopropylcarbaMoyl)benzoate(229648-45-7)

Safety Data

• Hazardous Substances Data: 229648-45-7(Hazardous Substances Data)

Upstream product

• 7377-26-6 4-Methoxycarbonylbenzoyl chloride 
• 75-31-0 isopropylamine 
• 1679-64-7 Monomethyl terephthalate 

Downstream Products

• 1611477-42-9 C₁₂H₁₄ClNO₂ 
• 1671087-28-7 methyl 4-((isopropylimino)methyl)benzoate 
• 1571-08-0 methyl 4-formylbenzoate 
• 952708-84-8 methyl 4-[(isopropylamino)methyl]benzoate 
• 1129-35-7 4-cyanobenzoic acid methyl ester 
• 1363415-72-8 methyl 4-undecanoylbenzoate 

Relevant articles and documents

Novel Human Aminopeptidase N Inhibitors: Discovery and Optimization of Subsite Binding Interactions

Aminopeptidase N (APN/CD13) is a zinc-dependent M1 aminopeptidase that contributes to cancer progression by promoting angiogenesis, metastasis, and tumor invasion. We have previously identified hydroxamic acid-containing analogues that are potent inhibitors of the APN homologue from the malarial parasite Plasmodium falciparum M1 aminopeptidase (PfA-M1). Herein, we describe the rationale that underpins the repurposing of PfA-M1 inhibitors as novel APN inhibitors. A series of novel hydroxamic acid analogues were developed using a structure-based design approach and evaluated their inhibition activities against APN. N-(2-(Hydroxyamino)-2-oxo-1-(3′,4′,5′-trifluoro-[1,1′-biphenyl]-4-yl)ethyl)-4-(methylsulfonamido)benzamide (6ad) proved to be an extremely potent inhibitor of APN activity in vitro, selective against other zinc-dependent enzymes such as matrix metalloproteases, and possessed limited cytotoxicity against Ad293 cells and favorable physicochemical and metabolic stability properties. The combined results indicate that compound 6ad may be a useful lead for the development of anticancer agents.

Tf2O-Mediated Intermolecular Coupling of Secondary Amides with Enamines or Ketones: A Versatile and Direct Access to β-Enaminones

Based on the Tf2O-mediated intermolecular reaction of secondary amides with enamines derived from ketones, a novel approach to β-enaminones has been developed. The reaction is widely functional group tolerant and highly chemoselective. In the presence of 4 ? molecular sieves, the method can be extended to the one-pot condensation of secondary amides with ketones for NH β-enaminones synthesis.

METHOD FOR THE CATALYTIC REDUCTION OF ACID CHLORIDES AND IMIDOYL CHLORIDES

The present application relates to methods for the catalytic reduction of acid chlorides and/or imidoyl chlorides. The methods comprise reacting the acid chloride or imidoyl chloride with a silane reducing agent in the presence of a catalyst such as [Cp(Pri3P)Ru(NCMe)2]+[PF6]?.