23000-15-9Relevant articles and documents
Design, synthesis and X-ray structure of protein-ligand complexes: Important insight into selectivity of memapsin 2 (β-secretase) inhibitors
Ghosti, Arun K.,Kumaragurubaran, Nagaswamy,Hong, Lin,Lei, Hui,Hussain, Khaja Azhar,Liu, Chun-Feng,Devasamudram, Thippeswamy,Weerasena, Vajira,Turner, Robert,Koelsch, Gerald,Bilcer, Geoffrey,Tang, Jordan
, p. 5310 - 5311 (2006)
Structure-based design, synthesis, and X-ray structure of protein-ligand complexes of memapsin 2 are described. The inhibitors are designed specifically to interact with S2- and S3-active site residues to provide selectivity over mem
Expeditious syntheses of conjugated allenyl esters and oxazoles through a cascade reaction of α-alkynyl malonates under alkaline conditions
Sano, Shigeki,Shimizu, Hisashi,Kim, Kweon,Lee, Woo Song,Shiro, Motoo,Nagao, Yoshimitsu
, p. 196 - 203 (2007/10/03)
Diethyl α-alkynyl-α-methoxymalonates (2a-e) were smoothly hydrolyzed and then decarboxylated under alkaline conditions employing 1 N KOH in EtOH to give conjugated allenyl esters (6a-e) in high yields, and similar alkaline treatment of diethyl α-alkynyl-α
The synthesis of oxazoles by thermolysis or photolysis of 2-acylisoxazol-5-ones
Ang, Kiah H.,Prager, Rolf H.,Smith, Jason A.,Weber, Ben,Williams, Craig M.
, p. 675 - 678 (2007/10/02)
N-acylisoxazol-5-ones are converted into the corresponding 2-substituted oxazoles by photolysis at 300 or 254 nm, or by flash vacuum pyrolysis. The former procedure is favoured for isoxazolones with electron withdrawing groups at C-4, and pyrolysis for all others.
