23432-39-5

Basic information

• Product Name: 4-HYDROXY-6-METHOXYQUINOLINE
• Synonyms: 6-METHOXYQUINOLIN-4(1H)-ONE;6-METHOXYQUINOLIN-4-OL;6-METHOXY-4-QUINOLINOL;6-METHOXY-4(1H)-QUINOLINONE;6-METHOXY-4-HYDROXYQUINOLINE;4-HYDROXY-6-METHOXYQUINOLINE;6-Methoxy-4(1H)-quinolinone([13788-72-2]);Nsc76096
• CAS NO: 23432-39-5
• Molecular Formula: C₁₀H₉NO₂
• Molecular Weight: 175.18
• EINECS: -0
• Product Categories: Quinoline&Isoquinoline
• Mol File: 23432-39-5.mol
• Article Data: 13

Chemical Properties

• Melting Point: 225-244 °C(Solv: water (7732-18-5))
• Boiling Point: 351.846 °C at 760 mmHg
• Flash Point: 166.591 °C
• Appearance: /
• Density: 1.258 g/cm³
• Vapor Pressure: 0.000296mmHg at 25°C
• Refractive Index: 1.573
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.40±0.40(Predicted)
• CAS DataBase Reference: 4-HYDROXY-6-METHOXYQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXY-6-METHOXYQUINOLINE(23432-39-5)
• EPA Substance Registry System: 4-HYDROXY-6-METHOXYQUINOLINE(23432-39-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 23432-39-5(Hazardous Substances Data)

Usage

General Description

4-Hydroxy-6-methoxyquinoline is a chemical compound with the molecular formula C10H9NO2. It belongs to the class of quinoline derivatives and is commonly used as an intermediate in the synthesis of pharmaceuticals and organic compounds. 4-HYDROXY-6-METHOXYQUINOLINE has been studied for its potential therapeutic properties, particularly as an anti-inflammatory and antifungal agent. 4-Hydroxy-6-methoxyquinoline may also have applications in the development of new drugs for the treatment of various diseases and conditions. Additionally, it is used in the production of dyes, perfumes, and other industrial products.

InChI:InChI=1/C10H9NO2/c1-13-7-2-3-9-8(6-7)10(12)4-5-11-9/h2-6H,1H3,(H,11,12)

Upstream product

• 4295-04-9 4-chloro-6-methoxyquinoline 
• 3835-21-0 6-methoxy-2,3-dihydroquinolin-4(1H)-one 
• 28027-16-9 4-hydroxy-6-methoxy-3-quinoline carboxylic acid 
• 91092-95-4 6-methoxykynurenic acid 
• 66003-25-6 ethyl 4-hydroxy-6-methoxy-2-quinolinecarboxylate 
• 675578-61-7 N-p-toluenesulfonyl-4-(tert-butyldimethylsiloxy)-6-methoxy-1,2-dihydroquinoline 
• 2033-24-1 cycl-isopropylidene malonate 
• 123-11-5 4-methoxy-benzaldehyde 
• 25063-43-8 2,2-dimethyl-5-(((4-methoxyphenyl)amino)methylene)-1,3-dioxane-4,6-dione 
• 77156-78-6 ethyl 4-hydroxy-6-methoxyquinoline-3-carboxylate 
• 104-94-9 4-methoxy-aniline 
• 675578-58-2 N-(2-acetyl-4-methoxyphenyl)-4-methylbenzenesulfonamide 
• 23042-77-5 1-(2-amino-5-methoxy-phenyl)-ethanone 
• 675578-59-3 N-allyl-N-p-toluenesulfonyl-2-acetyl-4-methoxyaniline 

Downstream Products

• 42881-66-3 4-bromo-6-methoxyquinoline 
• 148018-29-5 4-chloro-quinolin-6-ol 
• 426842-72-0 3-chloro-4-hydroxy-6-methoxyquinoline 
• 611-35-8 4-chloroquinoline 

Relevant articles and documents

The design, synthesis, in silico ADME profiling, antiplasmodial and antimycobacterial evaluation of new arylamino quinoline derivatives

A series of new arylamino quinoline derivatives was designed based on the quinine and mefloquine scaffolds and evaluated in vitro for antiplasmodial and antimycobacterial activities. A number of these compounds exhibited significant activity against the d

Synthesis of novel 3,4,6-trisubstituted quinolines enabled by a Gould-Jacobs cyclization

A Gould-Jacobs cyclization enabled the synthesis of several novel, so far undescribed 3,4,6-trisubstituted quinoline derivatives. They all bear substituents which are well-suited for further transformations, e.g. carboxylic acid or ester functions, haloge

Highly efficient thermal cyclization reactions of alkylidene esters in continuous flow to give aromatic/heteroaromatic derivatives

Intramolecular thermal cyclization and benzannulation reactions of the Gould-Jacobs and Conrad-Limpach types were performed in a designed continuous flow reactor system at temperatures in the range of 300-360°C and under high pressure conditions (100-160 bar) with very short residence times (0.45-4.5 min) in tetrahydrofuran as a low-boiling point solvent. Substituted heteroaromatic compounds including pyridopyrimidinones and hydroxyquinolines were synthesized in moderate to high yields. Application of the reaction conditions also allows the synthesis of naphthol and biphenyl derivatives. The procedure involves an easy work-up and the non-batchwise preparative synthesis method is suitable for automation.