235-06-3

Basic information

• Product Name: 1,2,4-TRIAZOLO[4,3-A]QUINOLINE
• Synonyms: 2,3,9b-Triazabenz[e]indene;2,3,9b-Triazabenz[g]indene;S-TRIAZOLO[4,3-A]QUINOLINE;TRIAZOLO (4,3A) QUINOLINE;1,2,4-TRIAZOLO[4,3-A]QUINOLINE;1,2,4-Triazolo[4,3-alpha]quinoline;1,2,4-Triazolo[4,3-a]auinoline;1,2,4-TRIAZOLO[4,3-A]QUINOLINE 99%
• CAS NO: 235-06-3
• Molecular Formula: C₁₀H₇N₃
• Molecular Weight: 169.18
• EINECS: 205-943-3
• Mol File: 235-06-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 175-177 °C
• Boiling Point: 288.47°C (rough estimate)
• Flash Point: °C
• Appearance: /
• Density: 1.2396 (rough estimate)
• Refractive Index: 1.6550 (estimate)
• CAS DataBase Reference: 1,2,4-TRIAZOLO[4,3-A]QUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-TRIAZOLO[4,3-A]QUINOLINE(235-06-3)
• EPA Substance Registry System: 1,2,4-TRIAZOLO[4,3-A]QUINOLINE(235-06-3)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 235-06-3(Hazardous Substances Data)

Usage

Chemical Properties

light yellow powder

InChI:InChI=1/C10H7N3/c1-2-4-9-8(3-1)5-6-10-12-11-7-13(9)10/h1-7H

Upstream product

• 15793-77-8 2-hydrazinoquinoline 
• 64-18-6 formic acid 
• 122-51-0 orthoformic acid triethyl ester 
• 75-52-5 nitromethane 
• 68-12-2 N,N-dimethyl-formamide 
• 612-62-4 2-Chloroquinoline 

Downstream Products

• 580-22-3 2-aminoquinoline 

Relevant articles and documents

Nitroalkanes as electrophiles: Synthesis of triazole-fused heterocycles with neuroblastoma differentiation activity

We discovered a reaction of nitroalkanes with 2-hydrazinylquinolines, 2-hydrazinylpyridines and bis-2,4-dihydrazinylpyrimidines in polyphosphoric acid (PPA) affording 1,2,4-triazolo[4,3-a]quinolines, 1,2,4-triazolo[4,3-a]pyridines and bis[1,2,4]triazolo[4,3-a:4′,3′-c]pyrimidines, respectively. The reaction expands the scope of heterocyclic annulations involving phosphorylated nitronates, believed to be the electrophilic intermediates formed from nitroalkanes in PPA. Several of the synthesized triazoles showed promising anticancer activity by inducing differentiation in neuroblastoma cancer cells. Due to the urgent need for novel differentiation agents for neuroblastoma therapy, this finding warrants further evaluation of this class of compounds against neuroblastoma.

Agent for the control of plant-pathogenic organisms

Methods employing and compositions comprising, for the control of plant-pathogenic organisms, specified s-triazolo(4,3-a)quinoline compounds, some of which are claimed as novel compounds.