2402-99-5

Basic information

• Product Name: 3,5-DIBROMOPYRIDINE 1-OXIDE
• Synonyms: 3,5-Dibromopyridine-N-oxide,97%;3,5-dibroMo-1$l^{5}-pyridin-1-one;3,5-dibromo-1-oxidopyridin-1-ium;3,5-Dibromopyridine N-Oxide;Pyridine, 3,5-dibromo-,1-oxide;3,5-DibromopyridineN-oxide≥ 98% (GC);AURORA KA-3005;3,5-DIBROMOPYRIDINE 1-OXIDE
• CAS NO: 2402-99-5
• Molecular Formula: C₅H₃Br₂NO
• Molecular Weight: 252.89
• EINECS: -0
• Product Categories: Pyridine
• Mol File: 2402-99-5.mol
• Article Data: 16

Chemical Properties

• Melting Point: 134-144 °C
• Boiling Point: 387.1 °C at 760 mmHg
• Flash Point: 187.9 °C
• Appearance: Off-white to beige/Crystalline Powder
• Density: 2.15 g/cm³
• Vapor Pressure: 7.55E-06mmHg at 25°C
• Refractive Index: 1.652
• Storage Temp.: Room temperature.
• PKA: -0.72±0.10(Predicted)
• CAS DataBase Reference: 3,5-DIBROMOPYRIDINE 1-OXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DIBROMOPYRIDINE 1-OXIDE(2402-99-5)
• EPA Substance Registry System: 3,5-DIBROMOPYRIDINE 1-OXIDE(2402-99-5)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-20/21/22-36/38
• Safety Statements: 36/37/39-26-22-36
• Hazardous Substances Data: 2402-99-5(Hazardous Substances Data)

Usage

Chemical Properties

off-white to beige crystalline powder

InChI:InChI=1/C5H3Br2NO/c6-4-1-5(7)3-8(9)2-4/h1-3H

Upstream product

• 625-92-3 3,5-dibromopyridine 

Downstream Products

• 40360-47-2 2-chloro-3,5-dibromopyridine 
• 13626-17-0 3,5-dibromo-4-chloro-pyridine 
• 62516-09-0 3,5-dibromo-4-nitro-pyridine 1-oxide 
• 863445-30-1 3-bromo-5-[(4-fluorophenyl)methyl]-2-pyridinecarbonitrile 
• 1609674-93-2 2-chloro-3-((2-methylpyridin-3-yl)oxy)-5-(pyridin-2-ylthio)pyridine p-toluenesulfonate 
• 1416058-02-0 3-[(2-methylpyridin-3-yl)oxy]-5-(phenylsulfanyl)pyridine 1-oxide 
• 1416057-78-7 2-{3-[(2-methylpyridin-3-yl)oxy]-5-(phenylsulfanyl)pyridin-2-yl}-1,2-benzothiazol-3(2H)-one 1,1-dioxide 
• 1416057-79-8 C₂₄H₁₇N₃O₄S₂ 
• 1416058-03-1 3-[(4-chlorophenyl)sulfanyl]-5-[(2-methylpyridin-3-yl)oxy]pyridine 1-oxide 
• 1416057-80-1 2-{5-[(4-chlorophenyl)sulfanyl]-3-[(2-methylpyridin-3-yl)oxy]pyridin-2-yl}-1,2-benzothiazol-3(2H)-one 1,1-dioxide 
• 1416057-81-2 C₂₄H₁₆ClN₃O₄S₂ 
• 1416058-01-9 3-[(4-methoxyphenyl)sulfanyl]-5-[(2-methylpyridin-3-yl)oxy]pyridine 1-oxide 
• 1416057-76-5 2-{5-[(4-methoxyphenyl)sulfanyl]-3-[(2-methylpyridin-3-yl)oxy]pyridin-2-yl}-1,2-benzothiazol-3(2H)-one 1,1-dioxide 
• 1416057-77-6 C₂₅H₁₉N₃O₅S₂ 

Relevant articles and documents

Water Can Accelerate Homogeneous Gold Catalysis

A selection of gold-catalyzed reactions was examined in a kinetic study on the influence of water on the rate constant. Two intramolecular reactions and one intermolecular reaction, which proceed via proton transfer and/or protodeauration steps, were inve

Reaction of Pyridine-N-Oxides with Tertiary sp2-N-Nucleophiles: An Efficient Synthesis of Precursors for N-(Pyrid-2-yl)-Substituted N-Heterocyclic Carbenes

N-(Pyrid-2-yl)-substituted azolium and pyridinium salts, precursors for hybrid NHC-containing ligands, were obtained with excellent regioselectivity, employing a deoxygenative CH-functionalization of pyridine-N-oxides with substituted imidazoles, thiazoles, and pyridine. Unlike the traditional SNAr-based methods, this approach provides high yields for substrates bearing substituents of different electronic nature. The utility of azolium and pyridinium salts thus prepared was also highlighted by the synthesis of pyridyl-substituted imidazolyl-2-thione, benzodiazepine as well as 2-aminopyridines.

A 3, 5 - dibromo pyridine - N - oxide preparation method

The invention discloses a preparation method of 3,5-dibromopyridine-N-oxide. The preparation method comprises the following steps: A), an organic solvent is added to 3,5-dibromopyridine to prepare a 3,5-dibromopyridine solution which is taken as a reaction liquid I, and a hydrogen peroxide solution with certain concentration is prepared to serve as a reaction liquid II; and B), the reaction liquid I and the reaction liquid II react sufficiently in a microreactor, off-white crystals, namely, 3,5-dibromopyridine-N-oxide, are obtained after separation and purification, wherein in the step B, the temperature of the microreactor is controlled in a range from 40 DEG C to 80 DEG C, and the pressure is 0-2 MPa. The preparation method of 3,5-dibromopyridine-N-oxide has the advantages as follows: the reaction yield is high, and the raw material utilization rate is increased; the method is simple and easy to operate, the production process is safe, and the reaction speed and the temperature are easy to control; the productivity is high, a flow reactor does not have an amplification effect, and the repeatability is good; few impurities are generated, and purification is easy; and little three wastes are generated, and the preparation method is a typical green technology.