24085-06-1

Basic information

• Product Name: 4-Acetoxy-3-acetoxymethylacetophenone
• Synonyms: 1-(4-(acetyloxy)-3-((acetyloxy)methyl)phenyl)-ethanon;1-(4-(acetyloxy)-3-((acetyloxy)methyl)phenyl)ethanone;4'-hydroxy-3'-(hydroxymethyl)acetophenone diacetate;2-ACETOXY-5-ACETYLBENZYL ACETATE;4-Acetyl-2-(acetoxymethyl)phenol acetate;4-Acetoxy-3-acetoxymethyla;4-Acetoxy-3-acetoxymethylacetophenone;(5-acetyl-2-acetyloxy-phenyl)methyl acetate
• CAS NO: 24085-06-1
• Molecular Formula: C₁₃H₁₄O₅
• Molecular Weight: 250.2473
• EINECS: 425-160-2
• Product Categories: Aromatics, Intermediates
• Mol File: 24085-06-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 381.7°Cat760mmHg
• Flash Point: 169.4°C
• Appearance: /
• Density: 1.183g/cm³
• Vapor Pressure: 4.98E-06mmHg at 25°C
• Refractive Index: 1.513
• CAS DataBase Reference: 4-Acetoxy-3-acetoxymethylacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Acetoxy-3-acetoxymethylacetophenone(24085-06-1)
• EPA Substance Registry System: 4-Acetoxy-3-acetoxymethylacetophenone(24085-06-1)

Safety Data

• Hazardous Substances Data: 24085-06-1(Hazardous Substances Data)

Usage

Chemical Properties

Colourless Oil

Uses

Salmeterol intermediate.

InChI:InChI=1/C13H14O5/c1-8(14)11-4-5-13(18-10(3)16)12(6-11)7-17-9(2)15/h4-6H,7H2,1-3H3

Upstream product

• 99-93-4 4-Hydroxyacetophenone 
• 39235-58-0 4-hydroxy-3-hydroxymethylacetophenone 
• 108-24-7 acetic anhydride 
• 24085-05-0 1-(3-chloromethyl-4-hydroxyphenyl)ethanone 
• 50-00-0 formaldehyd 
• 73096-98-7 3-dimethylaminomethyl-4-hydroxyacetophenone 

Downstream Products

• 64092-10-0 N-benzylsalbutamone 
• 34391-04-3 Levalbuterol 
• 67632-17-1 1(3'-valeryloxymethyl-4'-valeryloxyphenyl)-2-[1,1-dimethyl-2-(2-phenylacetamido)ethylamino]ethanol 
• 380414-69-7 (1R,1'S)-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-2-{(2-hydroxy-1-phenyl-ethyl)-[6-(4-phenyl-butoxy)-hexyl]-amino}-ethanol 
• 380414-68-6 (1R,1'S)-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-2-(2-hydroxy-1-phenyl-ethylamino)-ethanol 
• 380414-67-5 (1'S)-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-2-(2-hydroxy-1-phenyl-ethylamino)-ethanone 
• 102293-80-1 2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone 
• 62932-94-9 2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone 
• 135271-47-5 (R)-(-)-salmeterol 
• 24085-07-2 3'-acetoxymethyl-4'-acetoxy-2-bromoacetophenone 
• 77430-27-4 Acetic acid 2-acetoxymethyl-4-[2-(benzyl-tert-butyl-amino)-acetyl]-phenyl ester 
• 67632-19-3 3'-valeryloxy-methyl-4'-valeryloxyacetophenone 
• 67632-20-6 1-[3-acetoxymethyl-4-acetoxyphenyl]-2-[1,1-dimethyl-2-(2-phenoxyacetamido)ethylamino]ethanol 
• 67632-14-8 1-[3-acetoxymethyl-4-acetoxyphenyl]-2-[1,1-dimethyl-2-(2-phenylacetamido)ethyl amino]ethanol 

Relevant articles and documents

Preparing method of levalbuterol

The invention provides a preparing method of levalbuterol (5) shown in the formula (5). The preparing method includes the steps that a compound shown in the formula (1) reacts with formaldehyde and acetic anhydride to obtain a compound (2) shown in the formula (2); a compound (3) shown in the formula (3) is obtained through bromination; a compound (4) shown in the formula (4) is obtained through asymmetric reduction; the compound finally reacts with tert-butylamine, and the protecting group is removed to obtain levalbuterol (5) shown in the formula (5). The preparing method is simple in path, easy to operate, mild in reaction condition, high in yield and stereoselectivity and low in industrial production, and has short steps and high practical application value and social economic benefits.

Synthesis of the β2 Agonist (R)-Salmeterol Using a Sequence of Supported Reagents and Scavenging Agents

(Matrix Presented) The enantioselective synthesis of (R)-salmeterol has been achieved by using a sequence of supported reagents and sequestering agents. The saligenin core was installed by a regiospecific alkylation and a chiral auxiliary approach was employed to introduce the desired stereochemistry via a diastereoselective reduction.