380414-67-5Relevant articles and documents
Synthesis of the β2 Agonist (R)-Salmeterol Using a Sequence of Supported Reagents and Scavenging Agents
Bream, Robert N.,Ley, Steven V.,Procopiou, Panayiotis A.
, p. 3793 - 3796 (2002)
(Matrix Presented) The enantioselective synthesis of (R)-salmeterol has been achieved by using a sequence of supported reagents and sequestering agents. The saligenin core was installed by a regiospecific alkylation and a chiral auxiliary approach was employed to introduce the desired stereochemistry via a diastereoselective reduction.
A mild, enantioselective synthesis of (R)-salmeterol via sodium borohydride-calcium chloride asymmetric reduction of a phenacyl phenylglycinol derivative
Bream, Robert N.,Ley, Steven V.,McDermott, Benjamin,Procopiou, Panayiotis A.
, p. 2237 - 2242 (2007/10/03)
A short and efficient enantioselective route to (R)-salmeterol involving asymmetric reduction of a phenylglycinyl ketone derivative followed by reductive amination of the resulting amino alcohol and hydrogenolysis is described.