24334-54-1Relevant articles and documents
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Freeman et al.
, p. 815 (1982)
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A new modification of the Passerini reaction: A one-pot synthesis of α-acyloxyamides via sequential Kornblum oxidation/Passerini reaction
Adib, Mehdi,Sheikhi, Ehsan,Azimzadeh, Marjan
, p. 1933 - 1936 (2015/03/30)
Abstract A novel approach for the synthesis of α-acyloxyamides is described. Benzylic substrates (halides or tosylates), under mild Kornblum conditions, are oxidized to give the corresponding aldehydes, which undergo a Passerini reaction with carboxylic acids and isocyanides to produce the corresponding α-acyloxyamides in excellent yields.