24554-26-5 Usage
General Description
Dark yellow powder or gold solid.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
A nitrated organosulfide and amide. Organosulfides are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition N-[4-(5-Nitro-2-furyl)-2-thiazolyl]formamide. emits very toxic fumes of sulfur oxides and nitrogen oxides.
Fire Hazard
Flash point data for N-[4-(5-Nitro-2-furyl)-2-thiazolyl]formamide. are not available. N-[4-(5-Nitro-2-furyl)-2-thiazolyl]formamide. is probably combustible.
Safety Profile
Suspected carcinogen
with experimental carcinogenic, tumorigenic
data. Mutation data reported. Experimental
reproductive effects. When heated to
decomposition it emits very toxic fumes of
SOx and NOx.
Check Digit Verification of cas no
The CAS Registry Mumber 24554-26-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,5,5 and 4 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 24554-26:
(7*2)+(6*4)+(5*5)+(4*5)+(3*4)+(2*2)+(1*6)=105
105 % 10 = 5
So 24554-26-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H5N3O4S/c12-4-9-8-10-5(3-16-8)6-1-2-7(15-6)11(13)14/h1-4H,(H,9,10,12)
24554-26-5Relevant articles and documents
1H and 13C NMR Study of 2-Aminothiazole Urinary Tract Carcinogens
Davidson, R. M.,Rice, J. R.,Lakshmi, V. M.,Zenser, T. V.,Davis, B. B.
, p. 482 - 487 (2007/10/02)
Using 1H and 13C NMR, 13C-labelled modifications of 2-amino-4-(5-nitro-2-furyl)thiazole (ANFT) and its N-formyl analogue N-formamide (FANFT), as well as the 5-(S)-substituted glutathione and N-acetylcysteine conjugates of prostaglandin H synthase-catalyzed peroxidative metabolism of ANFT were studied. 1H and 13C NMR chemical shifts, heteronuclear coupling constants, spin-lattice relaxation times (T1) and nuclear Overhauser enhancements (NOE) were obtained.Three-bond coupling constants of the 13C-labelled nucleus with the C-5 protons of ANFT and FANFT were in close agreement but were absent in the conjugates owing to the 5-substitution.Two-bond coupling of the 13C-labelled nucleus was observed with the amide proton of FANFT, but not with ANFT because of rapid exchange of the amine protons.Values of T1 were smaller in the conjugates than in FANFT or ANFT owing to their larger molecular weights. 1H spectra and NOEs provide further support for the prevalence of the 2-aminothiazole tautomer over the 2-iminothiazoline tautomer.Evidence is presented for a proton transfer of the C-5 proton of ANFT, which proceeds over a time of the order of weeks in dimethyl sulphoxide and is autocatalytic.FANFT showed a different proton-transfer reaction involving the amide proton, which occurs on a time scale of the order of days in dimethyl sulphoxide.The FANFT molecule revealed no evidence for transfer of its C-5 proton, in contradistinction to ANFT.From a calculation of the percentage of the 13C relaxation due to the dipole-dipole mechanism, it can be concluded that for this class of sp2-hybridized carbon (the C-2-position of the 2-aminothiazole system) a considerable portion of t he relaxation is due to mechanisms other than dipolar.KEY WORDS NMR study 2-aminothiazole Urinary tract carcinogens.
