246139-77-5

Basic information

• Product Name: 6-TERT-BUTYL-PYRIDINE-3-CARBALDEHYDE
• Synonyms: 6-TERT-BUTYLNICOTINALDEHYDE;6-TERT-BUTYL-PYRIDINE-3-CARBALDEHYDE;2-BROMO-4-TERT-BUTYL-BENZALDEHYDE;2-Bromo-4-(1,1-dimethylethyl)-benzaldehyde;4-(tert-Butyl)-2-bromobenzaldehyde;Benzaldehyde, 2-bromo-4-(1,1-dimethylethyl)-
• CAS NO: 246139-77-5
• Molecular Formula: C₁₁H₁₃BrO
• Molecular Weight: 163.21632
• Product Categories: CHIRAL CHEMICALS
• Mol File: 246139-77-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 274.9±28.0 °C(Predicted)
• Appearance: /
• Density: 1.310±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 6-TERT-BUTYL-PYRIDINE-3-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-TERT-BUTYL-PYRIDINE-3-CARBALDEHYDE(246139-77-5)
• EPA Substance Registry System: 6-TERT-BUTYL-PYRIDINE-3-CARBALDEHYDE(246139-77-5)

Safety Data

• Hazardous Substances Data: 246139-77-5(Hazardous Substances Data)

Usage

General Description

6-Tert-butyl-pyridine-3-carbaldehyde is a chemical compound with the molecular formula C13H15NO. It is a derivative of pyridine and is commonly used as a reagent in organic synthesis. This chemical is known for its strong, pungent odor and it is often used to impart a floral and woody fragrance to various products such as perfumes, soaps, and detergents. It is also used in the production of various pharmaceuticals and agrochemicals. Additionally, 6-tert-butyl-pyridine-3-carbaldehyde has been studied for its potential use in the development of new materials and as an intermediate in the synthesis of other organic compounds.

Upstream product

• 246139-76-4 2-bromo-1-(bromomethyl)-4-(tert-butyl)benzene 
• 26670-89-3 2-bromo-4-iodo-1-methylbenzene 
• 61024-94-0 2-bromo-4-tert-butyl-1-methylbenzene 
• 98-51-1 4-tert-butyltoluene 
• 79-46-9 2-nitropropane 

Downstream Products

• 1010446-99-7 4-t-butyl-2-trimethylsilylethynylbenzaldehyde 
• 1394833-13-6 1,8-bis(2-formyl-5-t-butylphenylethynyl)pyrene 
• 1400743-02-3 C₂₁H₃₁BO₃ 
• 65188-53-6 2-bromo-4-tert-butyl-1-ethenylbenzene 
• 1383611-42-4 (1R,2R)-N,N-bis[4-(tert-butyl)-2-(tert-butylthio)benzylidene]-1,2-cyclohexanediamine 
• 1383612-01-8 4-(tert-butyl)-2-(tert-butylthio)benzaldehyde 
• 1610735-50-6 4-tert-butyl-2-ethynyl-1-(methoxy(phenyl)methyl)benzene 
• 1610735-62-0 5-tert-butyl-1-phenyl-1H-inden-2(3H)-one 
• 1610735-54-0 6-tert-butyl-3-phenyl-2,3-dihydro-1H-inden-1-one 
• 246139-79-7 4-tert-butyl-2-trimethylsilanylethynyl-benzoic acid 4-methoxy-benzyl ester 
• 246139-74-2 4-tert-butyl-2-ethynyl-benzoic acid 4-methoxy-benzyl ester 
• 246139-78-6 2-bromo-4-tert-butyl-benzoic acid 4-methoxy-benzyl ester 
• 545395-56-0 ethyl 2-[(1E)-2-(N-(2H,3H-benzo[e]1,4-dioxan-6-yl)carbamoyl)vinyl]-5-(tert-butyl)benzoate 

Relevant articles and documents

Bis-Cyclometalated Indazole Chiral-at-Rhodium Catalyst for Asymmetric Photoredox Cyanoalkylations

A new class of bis-cyclometalated rhodium(III) catalysts containing two inert cyclometalated 6-tert-butyl-2-phenyl-2H-indazole ligands and two labile acetonitriles is introduced. Single enantiomers (>99 % ee) were obtained through a chiral-auxiliary-mediated approach using a monofluorinated salicyloxazoline. The new chiral-at-metal complex is capable of catalyzing the visible-light-induced enantioselective α-cyanoalkylation of 2-acyl imidazoles in which it serves a dual function as the chiral Lewis acid catalyst for the asymmetric radical chemistry and at the same time as the photoredox catalyst for the visible-light-induced redox chemistry (up to 80 % yield, 4:1 d.r., and 95 % ee, 12 examples).

Asymmetric hydrogenation of ketones with H2 and ruthenium catalysts containing chiral tetradentate S2N2 ligands

Getting more for less: In the presence of H2 and a base, air- and moisture-tolerant RuII complexes catalyze the hydrogenation of ketones and aldehydes with excellent activity and chemoselectivity, and with enantioselectivity of up to 95 % under mild conditions. The ratio of substrate to catalyst can be lowered to 106:1. The reactions tolerate scale-up and can be carried out with almost no solvent. A base-free method is available for base-sensitive substrates. Copyright

Discovery of potent, orally available vanilloid receptor-1 antagonists. Structure-activity relationship of N-aryl cinnamides

The vanilloid receptor-1 (TRPV1 or VR1) is a member of the transient receptor potential (TRP) family of ion channels and plays a role in regulating the function of sensory nerves. A growing body of evidence demonstrates the therapeutic potential of TRPV1 modulators, particularly in the management of pain. As a result of our screening efforts, we identified (E)-3-(4-tert- butylphenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylamide (1), an antagonist that blocks the capsaicin-induced and pH-induced uptake of 45Ca2+ in TRPV1-expressing Chinese hamster ovary cells with IC50 values of 17 ± 5 and 150 ± 80 nM, respectively. In this report, we describe the synthesis and structure-activity relationship of a series of N-aryl cinnamides, the most potent of which (49a and 49b) exhibit good oral bioavailability in rats (Foral = 39% and 17%, respectively).