24698-70-2

Basic information

• Product Name: Quinoline, 2-(4-chlorophenyl)-
• CAS NO: 24698-70-2
• Molecular Formula: C15H10ClN
• Molecular Weight: 239.704
• Mol File: 24698-70-2.mol
• Article Data: 107

Chemical Properties

• CAS DataBase Reference: Quinoline, 2-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Quinoline, 2-(4-chlorophenyl)-(24698-70-2)
• EPA Substance Registry System: Quinoline, 2-(4-chlorophenyl)-(24698-70-2)

Safety Data

• Hazardous Substances Data: 24698-70-2(Hazardous Substances Data)

Upstream product

• 103529-16-4 2-[(trimethylsilyl)ethynyl]aniline 
• 91-22-5 quinoline 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 14774-78-8 4-chlorophenyl lithium 
• 24668-08-4 (E)-1-(4-chlorophenyl)-3-(2-nitrophenyl)-2-propen-1-one 
• 5466-31-9 2-(4-chlorophenyl)quinoline-4-carboxylic acid 
• 873-73-4 4-n-chlorophenylacetylene 
• 271-58-9 anthranil 
• 5344-90-1 2-Aminobenzyl alcohol 
• 184849-67-0 1-(4-chlorophenyl)ethanone O-acetyl oxime 
• 5263-17-2 4-chloro-1-(2,2-dichloroethenyl)benzene 
• 77063-21-9 4-(4-chlorophenyl)-1,1,1-trifluorobut-3-yn-2-one 
• 623-03-0 4-Cyanochlorobenzene 
• 103-63-9 1-phenyl-2-bromoethane 

Downstream Products

• 1236385-06-0 4-chloro-2-(4-chlorophenyl)quinoline-1,3(2H)-dicarbaldehyde 
• 1354658-31-3 C₂₂H₁₄Cl₂N₂O₃ 
• 1016275-43-6 (?)-(S)-2-(4-chlorophenyl)-1,2,3,4-tetrahydroquinoline 
• 1312163-01-1 (+)-(R)-2-(4-chlorophenyl)-1,2,3,4-tetrahydroquinoline 

Relevant articles and documents

Method for synthesizing quinoline derivatives by copper catalysis

The invention relates to a method for synthesizing quinoline derivatives by copper catalysis. The method comprises the following steps: mixing 2-aminobenzyl alcohol, acetophenone derivatives, an alkaline reagent, a copper catalyst and a nitrogen-containing ligand in an organic solvent, and reacting at room temperature for 6-12h; and after the reaction is finished, sequentially carrying out concentration and column chromatography separation on the obtained reaction solution to obtain the corresponding quinoline derivative. Compared with the prior art, the method has the advantages that 2-aminobenzyl alcohol and acetophenone derivatives which are cheap and easy to obtain are used as raw materials, cuprous iodide CuI or cuprous bromide CuBr with stable properties is used as a catalyst, the quinoline skeleton-containing derivatives are directly constructed, use of toxic reagents is avoided, and the method conforms to the development concept of green chemistry; and the method has the advantages of simple operation, mild reaction conditions, good substrate universality and the like, and has huge application potential in the aspect of drug intermediate synthesis.

Ruthenium complex and preparation method thereof and catalytic application

The invention discloses a ruthenium complex and a preparation method thereof and catalytic application. The ruthenium complex is reported for the first time. Research finds that the ruthenium complexhas the activity of catalytically synthesizing quinazoline and derivatives thereof or catalytically synthesizing quinoline and derivatives thereof. When the ruthenium complex provided by the inventionis used for catalytic synthesis of quinazoline and derivatives thereof or quinoline and derivatives thereof, the ruthenium complex has the advantages of mild reaction conditions, wide substrate range, high catalytic product yield and good functional group tolerance, and is significantly superior to the prior art.

Porous FeO(OH) Dispersed on Mg-Al Hydrotalcite Surface for One-Pot Synthesis of Quinoline Derivatives

The use of ubiquities elements such as iron instead of expensive precious metals as catalysts is one goal toward realizing environmentally benign synthetic chemistry. Here, we report that porous FeO(OH) dispersed on Mg?Al hydrotalcite acts as a bifunctional heterogeneous catalyst in the one-pot synthesis of 2-substituted quinoline derivatives through dehydrogenative oxidation-cyclization reactions. The catalyst was prepared by a simple grafting method using FeCl3 and Mg?Al hydrotalcite. The prepared porous FeO(OH) possesses a higher surface area than those previously reported for α-FeO(OH) particles. The one-pot quinoline synthesis proceeded effectively under non-noble-metal catalysis in air without requiring additional homogeneous bases or solvents.