247237-38-3 Usage
Description
5-Chloro-2-[[(4-methylphenyl)sulfonyl]amino]benzoic acid methyl ester, also known as Methyl 5-Chloro-2-[[(4-methylphenyl)sulfonyl]amino]benzoate, is an organic compound that serves as a crucial reactant in the pharmaceutical industry. It is characterized by its unique chemical structure, which includes a benzoic acid core with a methyl ester group, a sulfonyl-linked amino group, and a chloro substituent. 5-Chloro-2-[[(4-methylphenyl)sulfonyl]amino]benzoic acid methyl ester plays a significant role in the synthesis of various pharmaceutical compounds due to its versatile reactivity and functional groups.
Uses
Used in Pharmaceutical Industry:
5-Chloro-2-[[(4-methylphenyl)sulfonyl]amino]benzoic acid methyl ester is used as a reactant for the synthesis of Tolvaptan (T536650) and its intermediates. Tolvaptan is a nonpeptide arginine vasopressin (AVP) V2 receptor antagonist, which is utilized in the treatment of various medical conditions, such as hyponatremia and autosomal dominant polycystic kidney disease (ADPKD). The compound's unique structure allows it to be a key component in the development of these therapeutic agents, contributing to their efficacy and safety profiles.
As a reactant in the synthesis of Tolvaptan, 5-Chloro-2-[[(4-methylphenyl)sulfonyl]amino]benzoic acid methyl ester is essential for the pharmaceutical industry because it enables the production of a drug that can effectively target and modulate the AVP V2 receptor. This modulation can lead to improved treatment outcomes for patients suffering from the aforementioned medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 247237-38-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,4,7,2,3 and 7 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 247237-38:
(8*2)+(7*4)+(6*7)+(5*2)+(4*3)+(3*7)+(2*3)+(1*8)=143
143 % 10 = 3
So 247237-38-3 is a valid CAS Registry Number.
InChI:InChI=1/C15H14ClNO4S/c1-10-3-6-12(7-4-10)22(19,20)17-14-8-5-11(16)9-13(14)15(18)21-2/h3-9,17H,1-2H3
247237-38-3Relevant articles and documents
Iodine(III) Reagent-Mediated Intramolecular Amination of 2-Alkenylanilines to Prepare Indoles
Zhao, Chun-Yang,Li, Kun,Pang, Yu,Li, Jia-Qing,Liang, Cui,Su, Gui-Fa,Mo, Dong-Liang
supporting information, p. 1919 - 1925 (2018/03/28)
A variety of 3-substituted and 2,3-disubstituted indoles were synthesized efficiently in good yields through the intramolecular amination of 2-alkenylanilines promoted by readily available iodine(III) reagents in a short reaction time. Mechanistic studies showed that the reaction pathway went through a nitrenium ion and that 3-acetoxy indoline was the key intermediate in the indole formation. The indole product was easily prepared on a gram scale and amination also proceeded smoothly using catalytic 3,5-dimethylphenyl iodine in the presence of mCPBA. Furthermore, the indolo[3,2-a]carbazole scaffold was prepared in good yield in six steps from commercial ortho-iodoaniline. (Figure presented.).
PROCESS FOR PREPARING TOLVAPTAN INTERMEDIATES
-
Page/Page column 7, (2012/04/23)
The present invention provides a novel process for the preparation of 7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one. The present invention also provides an improved process for the preparation of 7-chloro-1-(2-methyl-4-nitrobenzoyl)-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine. The present invention further provides an improved process for the preparation of 7-chloro-1-[2-methyl-4-[(2-methylbenzoyl)amino]benzoyl]-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine.
Sulfonamide derivatives
-
, (2008/06/13)
The present invention relates to microbicides for agricultural or horticultural use containing a sulfonamide derivative.