2475-92-5

Basic information

• Product Name: (1E)-1-(4-methoxyphenyl)ethanone oxime
• Synonyms: (1E)-N-hydroxy-1-(4-methoxyphenyl)ethanimine; Ethanone, 1-(4-methoxyphenyl)-, oxime; Ethanone, 1-(4-methoxyphenyl)-, oxime (9CI); ethanone, 1-(4-methoxyphenyl)-, oxime, (1E)-
• CAS NO: 2475-92-5
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.1891
• Mol File: 2475-92-5.mol
• Article Data: 132

Chemical Properties

• Boiling Point: 288.4°C at 760 mmHg
• Flash Point: 128.2°C
• Density: 1.06g/cm³
• Vapor Pressure: 0.00108mmHg at 25°C
• Refractive Index: 1.508
• CAS DataBase Reference: (1E)-1-(4-methoxyphenyl)ethanone oxime(CAS DataBase Reference)
• NIST Chemistry Reference: (1E)-1-(4-methoxyphenyl)ethanone oxime(2475-92-5)
• EPA Substance Registry System: (1E)-1-(4-methoxyphenyl)ethanone oxime(2475-92-5)

Safety Data

• Hazardous Substances Data: 2475-92-5(Hazardous Substances Data)

Usage

General Description

(1E)-1-(4-methoxyphenyl)ethanone oxime is a chemical compound with the molecular formula C9H11NO2. It is a ketoxime, which means it is derived from a ketone by the addition of a hydroxylamine group. (1E)-1-(4-methoxyphenyl)ethanone oxime is a pale yellow solid and is commonly used in organic synthesis as a reagent for the preparation of various compounds. It can undergo various chemical reactions, such as oxidation and reduction, to form different derivatives and products. Additionally, it has been studied for its potential pharmaceutical applications, particularly in the development of new drugs and medications. Overall, (1E)-1-(4-methoxyphenyl)ethanone oxime is an important chemical with various synthetic and pharmaceutical uses.

Upstream product

• 6298-96-0 1-(4-methoxyphenyl)ethanamine 
• 768-60-5 4-methoxyphenylacetylen 
• 32117-52-5 1-(1-(4-methoxyphenyl)ethylidene)-2-tosylhydrazine 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 67-56-1 methanol 
• 123-11-5 4-methoxy-benzaldehyde 
• 79-24-3 Nitroethane 
• 100-66-3 methoxybenzene 
• 107093-09-4 1-Hydroxyamino-1-(4-methoxy-phenyl)-ethanol 
• 80965-21-5 (E)-1-(4-methoxyphenyl)ethan-1-one O-methyl oxime 
• 29865-61-0 1-(4-Methoxyphenyl)-2-nitropropane 

Downstream Products

• 96155-57-6 (E)-1-(4-methoxyphenyl)ethanone O-acetyl oxime 
• 71516-63-7 1-(4-Methoxy-phenyl)-ethanone O-[1-(4-methoxy-phenyl)-eth-(E)-ylideneaminooxymethyl]-oxime 
• 4995-12-4 2-(4-methoxyphenyl)-1H-pyrrole 
• 121505-80-4 1,2-bis(p-methoxyphenylethylideneaminooxy)ethane 
• 106702-11-8 1-(4-Methoxy-phenyl)-ethanone O-{2-[1-(4-methoxy-phenyl)-eth-(E)-ylideneaminooxy]-ethyl}-oxime 
• 80965-21-5 (E)-1-(4-methoxyphenyl)ethan-1-one O-methyl oxime 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 52751-67-4 3,5-bis-(4-methoxyphenyl) isoxazole 
• 1570194-67-0 1-(4-methoxyphenyl)ethan-1-one O-pivaloyl oxime 
• 1523451-38-8 6-methoxy-1-methyl-3,4-diphenylisoquinoline 2-oxide 
• 1613309-48-0 (4R,5S)-diphenylmethyl 1-(diphenylphosphoryl)-5-(4-methoxyphenyl)-5-methyl-4,5-dihydro-1H-imidazole-4-carboxylate 
• 1613309-40-2 (4R,5S)-tert-butyl 1-(diphenylphosphoryl)-5-(4-methoxyphenyl)-5-methyl-4,5-dihydro-1H-imidazole-4-carboxylate 

Relevant articles and documents

Polysubstituted Indole Synthesis via Palladium/Norbornene Cooperative Catalysis of Oxime Esters

Polysubstituted indoles are prevalent in pharmaceuticals, agrochemicals, and organic materials. Presented herein is the fact that polyfunctionalized indoles can be efficiently constructed from easily accessible oxime esters and aryl iodides, involving a palladium/norbornene synergistic synthesis. The reaction is enabled by a unique class of electrophiles in palladium/norbornene cooperative catalysis, which are oxime esters derived from simple ketone. The broad substrate scope and high functional group tolerance could make this method attractive for the synthesis of polysubstituted indoles.

AgNO3as Nitrogen Source for Cu-Catalyzed Cyclization of Oximes with Isocyanates: A Facile Route to N-2-Aryl-1,2,3-triazoles

A versatile copper-catalyzed [3 + 1 + 1] annulation of oximes and isocyanates with AgNO3 is described. In this conversion, AgNO3 and isocyanates instead of conventional azide or diazonium reagents were used as the nitrogen source. This three-component transformation was achieved by cleaving N-O/C-H/C-N bonds and building CN/N-N bonds, which provides a strategy to prepare N-2-aryl-1,2,3-triazoles with a good substrate and functional compatibility.

Rhodium(III)-Catalyzed Direct C-H Arylation of Various Acyclic Enamides with Arylsilanes

The stereoselective β-C(sp2)-H arylation of various acyclic enamides with arylsilanes via Rh(III)-catalyzed cross-coupling reaction was illustrated. The methodology was characterized by extraordinary efficacy and stereoselectivity, a wide scope of substrates, good functional group tolerance, and the adoption of environmentally friendly arylsilanes. The utility of this present method was evidenced by the gram-scale synthesis and further elaboration of the product. In addition, Rh(III)-catalyzed C-H activation is considered to be the critical step in the reaction mechanism.