2481-70-1

Basic information

• Product Name: ent-6-methyl-5α-ergoline-8β-carboxylic acid
• Synonyms: ent-6-methyl-5α-ergoline-8β-carboxylic acid
• CAS NO: 2481-70-1
• Molecular Weight: 270.331
• Mol File: 2481-70-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ent-6-methyl-5α-ergoline-8β-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: ent-6-methyl-5α-ergoline-8β-carboxylic acid(2481-70-1)
• EPA Substance Registry System: ent-6-methyl-5α-ergoline-8β-carboxylic acid(2481-70-1)

Safety Data

• Hazardous Substances Data: 2481-70-1(Hazardous Substances Data)

Upstream product

• 1752-45-0 rac-6-methyl-5α-ergoline-8β-carboxylic acid hydrazide 
• 1752-45-0 rac-6-methyl-5α-ergoline-8α-carboxylic acid hydrazide 
• 1752-45-0 rac-6-methyl-ergoline-8α-carboxylic acid hydrazide 
• 30341-92-5 #rac-ergoline-8α-carboxylic acid methyl ester 
• 1420013-09-7 N-(2-bromo-3-(2-methoxyvinyl)phenyl)acetamide 
• 3006-19-7 methyl (6aRS,9RS,10aSR)-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo<4,3-fg>quinoline-9-carboxylate 
• 51867-06-2 1-benzoyl-1,2,2a,3-tetrahydrobenzindol-4-(5H)-one 
• 158479-05-1 4-hydroxy-1,3,4,5-tetrahydrobenzindole 
• 1420013-23-5 N-(2-bromo-3-(2-hydroxy-5-(trimethylsilyl)pent-4-yn-1-yl)phenyl)acetamide 
• 1420013-02-0 C₁₀H₁₀BrNO₂ 
• 3006-19-7 methyl (6aRS,9SS,10aSR)-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo<4,3-fg>quinoline-9-carboxylate 
• 82-58-6 (+/-)-lysergic acid 
• 109502-14-9 rac-1-acetyl-6-methyl-(3β)-9,10-didehydro-2,3-dihydro-ergoline-8β-carbonitrile 

Downstream Products

• 2481-70-1 9,10-Dihydrolysergsaeure 
• 5878-43-3 9,10-dihydrolysergic acid 
• 3006-19-7 methyl (6aRS,9RS,10aSR)-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo<4,3-fg>quinoline-9-carboxylate 
• 62268-45-5 (6aS,9S)-7-Methyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinoline-9-carboxylic acid [(S)-1-((3S,8aS)-3-benzyl-1,4-dioxo-hexahydro-pyrrolo[1,2-a]pyrazine-2-carbonyl)-2-methyl-propyl]-amide 

Relevant articles and documents

Total synthesis of dihydrolysergic acid and dihydrolysergol: development of a divergent synthetic strategy applicable to rapid assembly of D-ring analogs

Abstract The total syntheses of dihydrolysergic acid and dihydrolysergol are detailed based on a Pd(0)-catalyzed intramolecular Larock indole cyclization for the preparation of the embedded tricyclic indole (ABC ring system) and a subsequent powerful inverse electron demand Diels-Alder reaction of 5-carbomethoxy-1,2,3-triazine with a ketone-derived enamine for the introduction of a functionalized pyridine, serving as the precursor for a remarkably diastereoselective reduction to the N-methylpiperidine D-ring. By design, the use of the same ketone-derived enamine and a set of related complementary heterocyclic azadiene [4+2] cycloaddition reactions permitted the late stage divergent preparation of a series of alternative heterocyclic derivatives not readily accessible by more conventional approaches.

Ergot alkaloids. 39. Synthesis of D-dihydrolysergic (I)-acid and of its methylester

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