249536-82-1

Basic information

• Product Name: methyl (1S,2S)-2-acetoxy-1-methyl-3-cyclopentenecarboxylate
• CAS NO: 249536-82-1
• Molecular Weight: 198.219
• Mol File: 249536-82-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl (1S,2S)-2-acetoxy-1-methyl-3-cyclopentenecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (1S,2S)-2-acetoxy-1-methyl-3-cyclopentenecarboxylate(249536-82-1)
• EPA Substance Registry System: methyl (1S,2S)-2-acetoxy-1-methyl-3-cyclopentenecarboxylate(249536-82-1)

Safety Data

• Hazardous Substances Data: 249536-82-1(Hazardous Substances Data)

Upstream product

• 108-05-4 vinyl acetate 
• 249537-15-3 (1S,2S)-2-Hydroxy-1-methyl-cyclopent-3-enecarboxylic acid methyl ester 

Downstream Products

• 206755-02-4 methyl (1S,4S)-4-hydroxy-1-methyl-2-cyclopentenecarboxylate 
• 249536-85-4 (1S,4S)-4-(tert-butyldiphenylsilyloxymethyl)-4-methyl-2-cyclopentenol 
• 206755-01-3 methyl (1S,2S)-2-hydroxy-1-methyl-3-cyclopentenecarboxylate 

Relevant articles and documents

Stereoselective synthesis of 4'-α-alkylcarbovir derivatives based on an asymmetric synthesis or chemoenzymatic procedure

Stereoselective synthesis of 4'-α-alkylcarbovir derivatives 4 was described based on asymmetric synthesis or a chemoenzymatic procedure. The asymmetric alkylation of chiral acetal 7 gave the alkylated enol ethers 9a - c possessing a chiral quaternary carbon. The key carbocyclic intermediates 14a - c were synthesized from 9a - c via eleven-steps. Coupling of 14a - c with 2-amino-6-chloropurine followed by desilylation and subsequent hydrolysis afforded the target compounds 4a - c in moderate yield. The optically active cyclopentene intermediates 5a - c and 6a - c were also prepared by enzymatic resolution of (±)-5a - c and (±)-6a - c, respectively.