25660-64-4

Basic information

• Product Name: 4-phenyl-1,2,3-selenadiazole
• Synonyms: 1,2,3-Selenadiazole, 4-phenyl-; 4-Phenyl-1,2,3-selenadiazole
• CAS NO: 25660-64-4
• Molecular Formula: C₈H₆N₂Se
• Molecular Weight: 209.1066
• Mol File: 25660-64-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 314.8°C at 760 mmHg
• Flash Point: 144.2°C
• Vapor Pressure: 0.000844mmHg at 25°C
• CAS DataBase Reference: 4-phenyl-1,2,3-selenadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-phenyl-1,2,3-selenadiazole(25660-64-4)
• EPA Substance Registry System: 4-phenyl-1,2,3-selenadiazole(25660-64-4)

Safety Data

• Hazardous Substances Data: 25660-64-4(Hazardous Substances Data)

Upstream product

• 98-86-2 acetophenone 
• 1402671-80-0 C₁₇H₂₅N₄O₂S⁽¹⁺⁾*CF₃O₃S^(1-) 
• 1261590-97-9 N'-[(1E)-1-phenylethylidene]-2-(quinolin-8-yloxy)acetohydrazone 
• 2492-30-0 acetophenone semicarbazone 
• 17539-55-8 acetophenone-(E)-semicarbazone 

Downstream Products

• 74277-54-6 [5-Phenyl-[1,3]thiaselenol-(2E)-ylidene]-carbamic acid ethyl ester 
• 1047719-64-1 4-phenyl-1,2,3-selenadiazole phenyldichloroborane complex 
• 1047719-63-0 4-phenyl-1,2,3-selenadiazole boron trifluoride complex 
• 107378-42-7 1,5-diphenyl-3-selena-4-pentyn-1-one 
• 78531-02-9 methyl 3-(2-phenylethynylseleno)-3-phenylpropenoate 
• 1128-52-5 5-phenyl-3-thioxo-1,3-thiaselenole 
• 19859-24-6 2-phenylethynyl methyl selenide 
• 64254-45-1 Dimethyl 4-phenyl-2,3-selenophenedicarboxylate 
• 536-74-3 phenylacetylene 
• 102104-52-9 2-Phenylethynylselanylmethyl-oxirane 
• 102104-56-3 1,3-Bis-phenylethynylselanyl-propan-2-ol 

Relevant articles and documents

Preparation of 2-Arylethynylselanylacetonitriles from 4-Aryl-1,2,3-selenadiazoles

Base decomposition of 4-(substituted phenyl)-1,2,3-selenadiazoles at room temperature resulted in 2-(substituted phenyl)-ethynylselenolate anions, which were immediately reacted with bromoacetonitrile to give a series of 2-(substituted phenyl)ethynylselan

Synthesis, characterization, antiamoebic activity and cytotoxicity of novel 2-(quinolin-8-yloxy) acetohydrazones and their cyclized products (1,2,3-thiadiazole and 1,2,3-selenadiazole derivatives)

A series of 1,2,3-thiadiazole and 1,2,3-selenadiazole derivatives were synthesized by the cyclization of novel 2-(quinolin-8-yloxy) acetohydrazones. In vitro antiamoebic activity was performed against HM1: IMSS strain of Entamoeba histolytica. The results showed that all the 2-(quinolin-8-yloxy) acetohydrazones were more active than their cyclized products (1,2,3-thiadiazole and 1,2,3-selenadiazole derivatives). SAR showed that the compounds having quinoline ring and hydrazone linkage with free N-H group are responsible for higher antiamoebic activity. The cytotoxic studies of these compounds on human breast cancer MCF-7 cell line showed that all the compounds were nontoxic at the concentration range of 1.56-50 μM.