25813-25-6

Basic information

• Product Name: 3,5-DIBROMO-4-PYRIDINOL
• Synonyms: 3,5-dibromo-4-pyridino;4-HYDROXY-3,5-DIBROMOPYRIDINE;3,5-DIBROMOPYRIDIN-4-OL;NSC 203048
• CAS NO: 25813-25-6
• Molecular Formula: C₅H₃Br₂NO
• Molecular Weight: 252.89
• Mol File: 25813-25-6.mol
• Article Data: 9

Chemical Properties

• Melting Point: 370℃ (dec.)
• Boiling Point: 279 °C at 760 mmHg
• Flash Point: 122.6 °C
• Appearance: /
• Density: 2.293 g/cm³
• PKA: 6.47±0.10(Predicted)
• CAS DataBase Reference: 3,5-DIBROMO-4-PYRIDINOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DIBROMO-4-PYRIDINOL(25813-25-6)
• EPA Substance Registry System: 3,5-DIBROMO-4-PYRIDINOL(25813-25-6)

Safety Data

• Hazardous Substances Data: 25813-25-6(Hazardous Substances Data)

Usage

General Description

3,5-DIBROMO-4-PYRIDINOL is a chemical compound with the molecular formula C5H3Br2NO. It is a brominated derivative of pyridinol, and its structure consists of a pyridine ring with two bromine atoms at the 3 and 5 positions, and a hydroxyl group at the 4 position. It is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also utilized as a building block in organic chemistry and as a reagent in various chemical reactions. 3,5-DIBROMO-4-PYRIDINOL is considered to be a hazardous substance and should be handled and disposed of in accordance with proper safety regulations.

InChI:InChI=1/C5H3Br2NO/c6-3-1-8-2-4(7)5(3)9/h1-2H,(H,8,9)

Upstream product

• 110-89-4 piperidine 
• 108-96-3 4-pyridone 
• 1124-33-0 4-nitraminopyridine N-oxide 
• 626-64-2 pyridin-4-ol 
• 694-59-7 pyridine N-oxide 

Downstream Products

• 13626-17-0 3,5-dibromo-4-chloro-pyridine 
• 1002727-49-2 3-bromo-5-(hydroxy(phenyl)methyl)pyridin-4-ol 
• 25813-24-5 3,5-dibromo-4-methoxypyridine 
• 1256821-58-5 7-bromo-1H-pyrazolo[4,3-c]pyridine 
• 1060802-24-5 5-bromo-4-chloro-pyridine-3-carbaldehyde 
• 1449299-95-9 N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-6'-fluoro-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydro-3,3'-bipyridine-5-carboxamide 
• 1052114-83-6 5-bromo-4-hydroxypyridine-3-carboxylic acid 
• 1214377-46-4 3-bromo-4-(difluoromethoxy)pyridine 
• 1357094-08-6 N-(4-(5-cyano-4-methoxy-3-pyridinyl)-3-methylphenyl)methanesulfonamide 
• 1357093-77-6 N-(4-(5-bromo-4-methoxypyridin-3-yl)-3-methylphenyl)methanesulfonamide 
• 36953-41-0 3-bromo-4-hydroxypyridine 
• 110-86-1 pyridine 
• 2683-35-4 3,5-dibromo-1-methylpyridin-4(1H)-one 

Relevant articles and documents

Preparation method of pyridine derivative (by machine translation)

To the method, piperidine-4-one hydrochloride is used as a raw material, and a series of pyridine derivatives are obtained through halogenation reaction and elimination reaction. The reaction is eliminated by reacting piperidine-4-one hydrochloride with a specific amount of the 3,5 - halogenating agent in a halogenation 3, 3, 5 - reaction with a halogen-3, 3, 5, 5 - based reaction, followed by reaction with a pyridine derivative of a hydroxyl group, an amino group 4 - or a dimethylamino group, respectively, by eliminating the reaction with a different kind of basic agent. The method is simple and convenient to operate, mild in condition, short in technological process, low in waste water yield, environment-friendly, low in cost and beneficial to green industrial production of the pyridine derivative. (by machine translation)

BIARYL DERIVATIVE AND MEDICINE CONTAINING SAME

Provided is a compound showing excellent antifungal activity against Trichophyton fungus, which is a major causative microorganism of superficial mycosis, and high effectiveness on diseases caused by Trichophyton fungi. A biaryl derivative represented by the formula (I) or a salt thereof: wherein ring A is an optionally substituted phenyl, or an optionally substituted 5- or 6-membered ring heteroaryl (ring A may be further condensed to form an optionally substituted fused ring); Q is CH2, C=O, NH, O, S or the like; X1, X2 and X3 are CR1 or N; Y is CH or N; Z is CR2b or N; R2a and R2b are each a hydrogen atom, a halogen atom, an optionally substituted C1-C6 alkyl group, a C1-C6 haloalkyl group or the like; R2a and R2b may form, together with carbon atoms bonded thereto, an optionally substituted carbocycle, or an optionally substituted heterocycle.

SULFONAMIDE COMPOUNDS USEFUL AS CYP17 INHIBITORS

Disclosed are sulfonamide compounds of Formula (I): or stereoisomers, N-oxides, prodrugs, or pharmaceutically acceptable salts thereof, wherein ring A, R1, R2, R3, R4 and R5 are defined herein. Also disclosed are methods of using such compounds in the treatment of conditions related to CYP17 enzyme, such as cancer, and pharmaceutical compositions comprising such compounds.