2589-73-3

Basic information

• Product Name: 4-HYDROXYOCTANOPHENONE
• Synonyms: 1-(4-hydroxyphenyl)-1-octanon;4-Octanoylphenol;Octanophenone, 4'-hydroxy-;1-(4-HYDROXYPHENYL)-1-OCTANONE;4-HYDROXYOCTANOPHENONE;1-(4-hydroxyphenyl)octan-1-one;Heptyl 4-hydroxyphenyl ketone
• CAS NO: 2589-73-3
• Molecular Formula: C14H20O2
• Molecular Weight: 220.31
• EINECS: 219-979-2
• Mol File: 2589-73-3.mol
• Article Data: 14

Chemical Properties

• Melting Point: 59-61°C
• Boiling Point: 365.3°Cat760mmHg
• Flash Point: 155.8°C
• Appearance: /
• Density: 1.008g/cm³
• Vapor Pressure: 7.54E-06mmHg at 25°C
• Refractive Index: 1.515
• Solubility: Dichloromethane, Diethyl Ether, Ethyl Acetate
• PKA: 8.16±0.15(Predicted)
• BRN: 1954746
• CAS DataBase Reference: 4-HYDROXYOCTANOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXYOCTANOPHENONE(2589-73-3)
• EPA Substance Registry System: 4-HYDROXYOCTANOPHENONE(2589-73-3)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36
• TSCA: Yes
• Hazardous Substances Data: 2589-73-3(Hazardous Substances Data)

Usage

Uses

4-Octanoylphenol is an intermediate in the synthesis of 4-Octylphenol Monoethoxylate which is widely used as nonionic surfactants.

InChI:InChI=1/C14H20O2/c1-2-3-4-5-6-7-14(16)12-8-10-13(15)11-9-12/h8-11,15H,2-7H2,1H3

Upstream product

• 111-64-8 n-octanoic acid chloride 
• 108-95-2 phenol 
• 7446-70-0 aluminium trichloride 
• 630-20-6 1,1,1,2-tetrachoroethane 
• 5457-78-3 phenyl octanoate 
• 102946-00-9 1-(4-octanoyloxy-phenyl)-octan-1-one 
• 98-95-3 nitrobenzene 
• 7705-08-0 iron(III) chloride 
• 75-15-0 carbon disulfide 
• 7550-45-0 titanium tetrachloride 
• 7646-78-8 tin(IV) chloride 
• 101-84-8 diphenylether 
• 106-41-2 4-bromo-phenol 
• 124-13-0 Octanal 

Downstream Products

• 102240-72-2 nicotinic acid-[1-(4-hydroxy-phenyl)-octylidenehydrazide] 
• 102240-70-0 isonicotinic acid-[1-(4-hydroxy-phenyl)-octylidenehydrazide] 
• 949-13-3 2-octylphenol 
• 1806-26-4 p-Octylphenol 
• 6814-22-8 4-octylhexanol 
• 3226-27-5 1-(2-hydroxy-phenyl)-octan-1-one 
• 17765-30-9 1-(4-hydroxy-phenyl)-octan-1-one-(2,4-dinitro-phenylhydrazone) 
• 17744-54-6 1-(2-hydroxy-phenyl)-octan-1-one-(2,4-dinitro-phenylhydrazone) 
• 102946-00-9 1-(4-octanoyloxy-phenyl)-octan-1-one 
• 80417-30-7 4-Ethoxy-benzoic acid 4-octanoyl-phenyl ester 
• 80417-26-1 4-Methoxy-benzoic acid 4-octanoyl-phenyl ester 
• 15234-81-8 2-Methyl-2-(4-octanoyl-phenoxy)-propionic acid 
• 15234-79-4 (4-Octanoyl-phenoxy)-acetic acid 
• 1539285-94-3 trifluoromethanesulfonic acid 4-octanoyl-phenyl ester 

Relevant articles and documents

Visible Light-Mediated [2 + 2] Cycloaddition Reactions of 1,4-Quinones and Terminal Alkynes

A single-step synthesis of 4-hydroxy-functionalized bi-aryl and aryl/alkyl ketones via oxidative coupling of terminal alkynes with benzoquinones is reported. Furthermore, with naphthoquinones, owing to the cross-resonance of carbonyl with the aromatic ring, alkene-alkyne cycloaddition is more favored to give four-membered carbocyclic adducts, thereby precluding the requirement of preactivated alkynes.

Synthesis, biochemical evaluation and rationalisation of a series of 3,5- dibromo derivatives of 4-hydroxyphenyl ketone-based compounds as probes of the active site of type 3 of 17β-hydroxysteroid dehydrogenase (17β-hsd3) and the role of hydrogen bonding interaction in the inhibition of 17β-HSD3

We report the synthesis, evaluation and rationalisation of the inhibitory activity of a series of 3,5-dibromo derivatives of 4-hydroxyphenyl ketone as probes of the active site of the type 3 of 17β-hydroxysteroid dehydrogenase (17β-HSD3). The results support the important role of hydrogen bonding interaction in the inhibition of 17β-HSD3.

Synthesis and critical micelle concentration of a series of gemini alkylphenol polyoxyethylene nonionic surfactants

A series of gemini n-alkylphenol polyoxyethylene surfactants (GAP) were successfully synthesized and their molecular structure were confirmed by NMR and FTIR spectrum. Using the same synthesis route, a Gemini nonylphenol polyoxyethylene surfactant (GNP) was synthesized using an industrial nonylphenol product and paraformaldehyde, and its molecular structure was also characterized by 1H-NMR and FTIR spectra. The optimal reaction conditions were established. The critical micelle concentration (CMC) values of GAP were determined by means of Wilhelmy plate method and steady-state fluorescence probe method. The experimental results show how the lengths of the hydrophilic polyoxyethylene chain and the hydrophobic tail alter the CMC values. The CMC values of the GAP are found to be much lower than those of corresponding conventional single tail nonionic surfactants of the polyethoxylated alkylphenol type, which indicates that the gemini species exhibit a better surface activity. AOCS 2011.