26055-95-8

Basic information

• Product Name: 3-Pyrrolidinol, 1-(phenylMethyl)-, 4-Methylbenzenesulfonate (ester)
• Synonyms: 3-Pyrrolidinol, 1-(phenylMethyl)-, 4-Methylbenzenesulfonate (ester);1-Benzyl-3-(4-toluenesulfonyloxy)pyrrolidine;1-Benzyl-3-(tosyloxy)pyrrolidine
• CAS NO: 26055-95-8
• Molecular Formula: C₁₈H₂₁NO₃S
• Molecular Weight: 331.42924
• Mol File: 26055-95-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.26
• CAS DataBase Reference: 3-Pyrrolidinol, 1-(phenylMethyl)-, 4-Methylbenzenesulfonate (ester)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyrrolidinol, 1-(phenylMethyl)-, 4-Methylbenzenesulfonate (ester)(26055-95-8)
• EPA Substance Registry System: 3-Pyrrolidinol, 1-(phenylMethyl)-, 4-Methylbenzenesulfonate (ester)(26055-95-8)

Safety Data

• Hazardous Substances Data: 26055-95-8(Hazardous Substances Data)

Upstream product

• 775-15-5 1-benzyl-3-pyrrolidinol 
• 98-59-9 p-toluenesulfonyl chloride 
• 101385-90-4 (S)-N-benzyl-3-hydroxypyrrolidine 

Downstream Products

• 666853-71-0 C₁₇H₂₅N₃O 
• 197964-14-0 2,2-diphenyl-2-[(3S)-N-benzyl-pyrrolidin-3-yl]acetonitrile 
• 20076-34-0 N-(1-Benzyl-3-pyrrolidinyl)aniline 

Relevant articles and documents

PROCESS FOR PREPARING 3-SUBSTITUTED PYRROLIDINE COMPOUNDS

Disclosed is a process for preparing 3 -substituted pyrrolidine compounds of formula (VII) or salts thereof, wherein R1 is described herein, which are intermediate compounds useful for the synthesis of darifenacin which is indicated for the treatment of overactive bladder with symptoms of urge, urinary incontinence, and the like, and pharmaceutically acceptable salts thereof. Also disclosed is a process for preparing darifenacin and pharmaceutically acceptable salts thereof.

N-Substituted-3-arylpyrrolidines: Potent and Selective Ligands at Serotonin 1A Receptor

3-Arylpyrrolidines are synthesized through the coupling of N-benzyl-3-(methanesulfonyloxy)pyrrolidine with diarylcuprates. Pharmacological evaluation of a series of N-substituted-3-arylpyrrolidines toward several neurotransmitter receptors indicated that some of them are good ligands for serotonin 1A receptor. Particularly, N-pyrrolidines were found to be potent and selective ligands. A preliminary biological evaluation for several selected compounds indicated that they are potentially effective antianxiety and antidepressant agents.