263758-69-6

Basic information

• Product Name: Butanoic acid, 4-(4-formyl-2-methoxy-5-nitrophenoxy)-
• CAS NO: 263758-69-6
• Molecular Formula: C12H13NO7
• Molecular Weight: 283.238
• Mol File: 263758-69-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 4-(4-formyl-2-methoxy-5-nitrophenoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 4-(4-formyl-2-methoxy-5-nitrophenoxy)-(263758-69-6)
• EPA Substance Registry System: Butanoic acid, 4-(4-formyl-2-methoxy-5-nitrophenoxy)-(263758-69-6)

Safety Data

• Hazardous Substances Data: 263758-69-6(Hazardous Substances Data)

Upstream product

• 141333-27-9 ethyl 4-(4-formyl-2-methoxyphenoxy)butanoate 
• 219931-67-6 ethyl 4-(4-formyl-2-methoxy-5-nitrophenoxy)butanoate 
• 121-33-5 vanillin 
• 176375-41-0 4-(4-formyl-2-methoxyphenoxy)butanoic acid methyl ester 
• 174358-69-1 4-(4-formyl-2-methoxyphenoxy)butyric acid 

Downstream Products

• 246048-10-2 4-(4-formyl-2-methoxy-5-nitro-phenoxy)-butyric acid 2,4,5-trichloro-phenyl ester 
• 246047-95-0 4-(4-hydroxymethyl-2-methoxy-5-nitro-phenoxy)-butyric acid 2,4,5-trichloro-phenyl ester 
• 355017-64-0 4-(4-(hydroxymethyl)-2-methoxy-5-nitrophenoxy)butanoic acid 
• 1392043-87-6 4-(4-(acryloyloxymethyl)-2-methoxy-5-nitrophenoxy)butanoic acid 

Relevant articles and documents

Erratum: Photodegradable macromers and hydrogels for live cell encapsulation and release (Journal of the American Chemical Society (2012) 134 (13103-13107) DOI: 10.1021/ja305280w)

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Improved utility of photolabile solid phase synthesis supports for the synthesis of oligonucleotides containing 3'-hydroxyl termini

Oligonucleotides are synthesized on, and cleaved from, a solid phase support (6) using the o-nitrobenzyl intramolecular photochemical redox reaction. The yields of isolated oligonucleotides relative to yields obtained using conventional hydrolytic cleavage vary between 67% and 82.5%. Synthesis of oligonucleotides using phosphoramidites that do not contain N-benzoyl protecting groups enables one to photolytically cleave the biopolymers in good yields using a commonly available UV irradiation source. Tritium labeling indicates that less than 3% thymidine·thymidine photodimers are formed during photolytic cleavage of polythymidylates from 6 using a transilluminator. No UV-induced damage is detected via HPLC analysis of enzymatically digested oligonucleotides that were obtained following photolytic cleavage from 6.