270065-52-6

Basic information

• Product Name: CBZ-PYR-OET
• Synonyms: CBZ-PYR-OET;(S)-1-Benzyl 2-ethyl 5-oxopyrrolidine-1,2-dicarboxylate
• CAS NO: 270065-52-6
• Molecular Formula: C15H17NO5
• Molecular Weight: 291.3
• Mol File: 270065-52-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 461.7±45.0 °C(Predicted)
• Appearance: /
• Density: 1.273±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -4.20±0.40(Predicted)
• CAS DataBase Reference: CBZ-PYR-OET(CAS DataBase Reference)
• NIST Chemistry Reference: CBZ-PYR-OET(270065-52-6)
• EPA Substance Registry System: CBZ-PYR-OET(270065-52-6)

Safety Data

• Hazardous Substances Data: 270065-52-6(Hazardous Substances Data)

Usage

General Description

Cbz-pyr-oet, also known as N-Cbz-L-prolinol ethyl ether, is a chemical compound commonly utilized in scientific research. In biochemistry and medical chemistry, it is often used as a reagent, a substance added to a system to bring about a chemical reaction or test. The molecular formula of this compound is C16H21NO3. Its physical and chemical properties include a molecular weight of 277.34 g/mol, boiling point of 554.8°C at 760 mmHg, and flash point of 288.7°C. It is identified by its CAS Number 173278-37-1 and should be handled with appropriate protective measures due to its reactivity.

Upstream product

• 31139-36-3 dibenzyl dicarbonate 
• 7149-65-7 ethyl (S)-pyroglutamate 
• 98-79-3 L-Pyroglutamic acid 
• 501-53-1 benzyl chloroformate 
• 4042-36-8 D-pyrrolidone-5-carboxylic acid 
• 68766-96-1 ethyl (R)-2-pyrrolidone-5-carboxylate 

Relevant articles and documents

Diastereoselective synthesis and biological evaluation of enantiomerically pure tricyclic indolines

Tricyclic indolines are common in both natural products and synthetic chemical probes. In this study we demonstrated that enantiomerically pure tricyclic indolines can be prepared from an inexpensive commercially available chiral starting material, pyroglutamic acid. The synthesis features a highly diastereoselective gold-catalyzed cyclization of alkyne-tethered indoles and subsequent diastereoselective reductive ring-opening reaction. Using this approach, we synthesized analogs of our previously discovered tricyclic indoline probes that possess antibacterial and resistance-modifying activity. The biological activity against methicillin-resistant Staphylococcus aureus (MRSA) of these analogues was evaluated and reported. The synthetic approach reported may be leveraged in the future to prepare diastereopure chemical probes for the determination of biological targets for drug discovery.

Convenient n-protection of L-pyroglutamic acid esters

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