27106-51-0

Basic information

• Product Name: 1-(TOLUENE-4-SULFONYL)-PIPERAZINE
• Synonyms: BUTTPARK 80\07-76;ART-CHEM-BB B003964;CHEMBRDG-BB 3003964;IFLAB-BB F1174-2442;1-(TOLUENE-4-SULFONYL)-PIPERAZINE;1-[(4-METHYLPHENYL)SULFONYL]PIPERAZINE;AKOS MSC-0754;AKOS B003964
• CAS NO: 27106-51-0
• Molecular Formula: C₁₁H₁₆N₂O₂S
• Molecular Weight: 240.32
• Mol File: 27106-51-0.mol
• Article Data: 29

Chemical Properties

• Melting Point: 97-100°C
• Boiling Point: 387.4°Cat760mmHg
• Flash Point: 188.1°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 3.31E-06mmHg at 25°C
• Refractive Index: 1.565
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 7.90±0.10(Predicted)
• CAS DataBase Reference: 1-(TOLUENE-4-SULFONYL)-PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(TOLUENE-4-SULFONYL)-PIPERAZINE(27106-51-0)
• EPA Substance Registry System: 1-(TOLUENE-4-SULFONYL)-PIPERAZINE(27106-51-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 27106-51-0(Hazardous Substances Data)

Usage

General Description

1-(Toluene-4-sulfonyl)-piperazine is a chemical compound that consists of a piperazine molecule with a toluene-4-sulfonyl group attached to it. It is often used as a reagent in organic synthesis and pharmaceutical research. 1-(TOLUENE-4-SULFONYL)-PIPERAZINE has been found to have potential applications in drug development, particularly in the design of antipsychotic and antidepressant medications. Additionally, 1-(toluene-4-sulfonyl)-piperazine has been reported to possess insecticidal properties, making it a candidate for agricultural and pest control applications. Its unique structure and reactivity make it a valuable building block for the synthesis of complex organic molecules and could hold promise for a variety of applications in the pharmaceutical and agricultural industries.

InChI:InChI=1/C11H16N2O2S/c1-10-2-4-11(5-3-10)16(14,15)13-8-6-12-7-9-13/h2-5,12H,6-9H2,1H3

Upstream product

• 110-85-0 piperazine 
• 1153-45-3 4-nitrophenyl 4-methylbenzenesulfonate 
• 98-59-9 p-toluenesulfonyl chloride 
• 284039-54-9 1-vinyloxycarbonylpiperazine 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 250331-04-5 tert-butyl 4-tosylpiperazine-1-carboxylate 
• 142-64-3 piperazine dihydrochloride 
• 2232-08-8 N-tosylimidazole 
• 742-25-6 2,4-dinitrophenyl 4-methylbenzenesulfonate 

Downstream Products

• 1061767-97-2 2-chloro-6,7-dimethoxy-4-(4-tosylpiperazin-1-yl)quinazoline monohydrochloride 
• 1264534-31-7 2-chloro-4-(4-tosylpiperazin-1-yl)quinazoline 
• 1309868-68-5 2-chloro-4-(4-tosylpiperazin-1-yl)pyrido[3,2-d]pyrimidine 
• 1309868-67-4 2-chloro-4-(4-tosylpiperazin-1-yl)pyrido[2,3-d]pyrimidine 
• 1264535-74-1 5-(4-(4-tosylpiperazin-1-yl)quinazolin-2-yl)thiazole 
• 1264535-91-2 2-(pyrimidin-5-yl)-4-(4-tosylpiperazin-1-yl)quinazoline 
• 1264534-04-4 4-(4-tosylpiperazin-1-yl)quinazoline-2-carbonitrile 
• 1264534-06-6 4-(4-tosylpiperazin-1-yl)quinazoline-2-carboxamide 
• 1264534-08-8 methyl 4-(4-tosylpiperazin-1-yl)quinazoline-2-carboxylate 
• 1264534-10-2 1-[4-(4-Tosylpiperazin-1-yl)quinazolin-2-yl]ethanone 
• 877042-72-3 4-(4-tosylpiperazin-1-yl)quinazoline 
• 1264534-14-6 2-(1H-benzo[d]imidazol-1-yl)-4-(4-tosylpiperazin-1-yl)quinazoline 
• 1264534-16-8 5-[4-(4-tosylpiperazin-1-yl)quinazolin-2-yl]thiophene-2-carbaldehyde 
• 1264534-18-0 {5-[4-(4-tosylpiperazin-1-yl)quinazolin-2-yl]-thiophen-2-yl}methanol 

Relevant articles and documents

Constructing the 2-(thiobenzyl)ethyl carbamate linker via thiyl radical addition

N-Vinyloxycarbonyl derivatives of secondary amines undergo efficient addition of thiyl radical and, using Merrifield SH resin, this reaction provides a new entry to resin-bound 2-(thiobenzyl)ethyl carbamates. (C) 2000 Elsevier Science Ltd.

Synthesis and antibacterial activity of novel myricetin derivatives containing sulfonylpiperazine

Myricetin derivatives containing sulfonylpiperazine were synthesized and their structures were confirmed by NMR and HRMS. The antibacterial activity results indicated that some compounds showed good antibacterial activity against Xanthomonas oryzaepv. ory

Design, synthesis and antitumor evaluation of new 1,8-naphthalimide derivatives targeting nuclear DNA

Four series of new 3-nitro naphthalimides derivatives, 4(4a?4f), 5(5a?5i), 6(6a?6e) and 7 (7a?7j), were designed and synthesized as antitumor agents. Methyl thiazolyl tetrazolium (MTT) screening assay results revealed that some compounds displayed effecti