271247-59-7

Basic information

• Product Name: N-Methoxy-N-Methyl-2-(Methylthio)pyriMidine-4-carboxaMide
• Synonyms: N-Methoxy-N-Methyl-2-(Methylthio)pyriMidine-4-carboxaMide;4-PyriMidinecarboxaMide, N-Methoxy-N-Methyl-2-(Methylthio)-
• CAS NO: 271247-59-7
• Molecular Formula: C₈H₁₁N₃O₂S
• Molecular Weight: 213.25684
• Mol File: 271247-59-7.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-Methoxy-N-Methyl-2-(Methylthio)pyriMidine-4-carboxaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Methoxy-N-Methyl-2-(Methylthio)pyriMidine-4-carboxaMide(271247-59-7)
• EPA Substance Registry System: N-Methoxy-N-Methyl-2-(Methylthio)pyriMidine-4-carboxaMide(271247-59-7)

Safety Data

• Hazardous Substances Data: 271247-59-7(Hazardous Substances Data)

Upstream product

• 1126-44-9 2-methylsulfanylpyrimidine-4-carboxylic acid 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 

Downstream Products

• 271247-49-5 (S)-3-[2-(α-methylbenzylamino)pyrimidin-4-yl]-4-(3-trifluoromethylphenyl)-6-(N-carbobenzoxypiperidin-4-yl)pyridazine 
• 271247-48-4 3-(2-methylsulfonylpyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-6-(N-carbobenzoxypiperidin-4-yl)pyridazine 
• 271247-47-3 3-(2-methylthiopyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-6-(N-carbobenzoxypiperidin-4-yl)peridazine 
• 443958-81-4 1-(2-methylthiopyrimidin-4-yl)-1-oxo-2-(3-trifluoromethylphenyl)-4-oxo-4-(N-carbobenzoxypiperidin-4-yl)butane 
• 271247-45-1 1-(2-methylthiopyrimidin-4-yl)-1-oxo-2-(3-trifluoromethylphenyl)ethane 

Relevant articles and documents

FURANONE COMPOUNDS AS KINASE INHIBITORS

The present disclosure provides novel furanone compounds, or pharmaceutically acceptable salts, solvates or prodrugs thereof, as Raf kinase, especially BRAF kinase, inhibitors, which are useful therapeutic agents for treatment of Raf kinase related diseases or disorders, such as melanomas, cancers, and leukemia. The disclosure also provides methods and processes for preparing these novel furanone compounds, pharmaceutical compositions containing these furanone compounds, and methods of treatment using these furanone compounds.