27169-29-5

Basic information

• Product Name: L-Glutamic acid, N-[N-[(phenylmethoxy)carbonyl]-L-a-glutamyl]-, trimethyl ester
• CAS NO: 27169-29-5
• Molecular Formula: C21H28N2O9
• Molecular Weight: 452.461
• Mol File: 27169-29-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: L-Glutamic acid, N-[N-[(phenylmethoxy)carbonyl]-L-a-glutamyl]-, trimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Glutamic acid, N-[N-[(phenylmethoxy)carbonyl]-L-a-glutamyl]-, trimethyl ester(27169-29-5)
• EPA Substance Registry System: L-Glutamic acid, N-[N-[(phenylmethoxy)carbonyl]-L-a-glutamyl]-, trimethyl ester(27169-29-5)

Safety Data

• Hazardous Substances Data: 27169-29-5(Hazardous Substances Data)

Usage

General Description

L-Glutamic acid, N-[N-[(phenylmethoxy)carbonyl]-L-a-glutamyl]-, trimethyl ester is a chemical compound that is a derivative of glutamic acid. It is a peptide that consists of a glutamic acid molecule attached to a phenylmethoxy carbonyl group. The trimethyl ester group is added to enhance the compound's stability and solubility. This chemical is often used in research and pharmaceutical applications as a prodrug form of glutamic acid, which can potentially be used to target specific receptors in the body. The compound's unique structure makes it a promising candidate for drug development and further study in the field of pharmacology.

Upstream product

• 6525-53-7 L-glutamic acid dimethyl ester 
• 4652-65-7 (S)-2-Benzyloxycarbonylamino-pentanedioic acid 5-methyl ester 
• 2018-66-8 Z-Leu-OH 
• 2666-93-5 (S)-Leu-OMe 

Downstream Products

• 1306771-20-9 C₃₃H₅₂N₈O₁₂ 
• 1306771-19-6 C₁₈H₂₈N₈O₆ 

Relevant articles and documents

Comprehensive screening of octopus amphiphiles as DNA activators in lipid bilayers: Implications on transport, sensing and cellular uptake

Dynamic octopus amphiphiles contain one charged "head," here a guanidinium cation, together several hydrophobic "tails" (or "tentacles") that can be attached and exchanged in situ by reversible hydrazone formation. Quite surprisingly, their ability to activate DNA as transporters in lipid bilayer membranes was found to increase with the number of tails (up to four) as well as with their length (up to eight carbons). Both encouraged and puzzled by these results, we decided that a comprehensive screening of octopus amphiphiles with regard to number (from one to six) and length (from three to eighteen carbons) of their tails would be appropriate at this point. For this purpose, we here report the synthesis of cationic hexahydrazide peptide dendrons together with that of aldehydes with long, saturated, unsaturated and branched hydrophobic tails. Comprehensive screening of the completed collection of tails and heads reveals that the ability of octopus amphiphiles to activate DNA transporters shifts with increasing number of tails to decreasing length of the tails. Moreover, cis-alkenyl and branched alkyl tails are more active than their linear analogs, branched aromatic tails are best. These overall very meaningful trends for octopus amphiphiles will be of importance for sensing applications and fragrant cellular uptake.

A simple and novel peptide bond formation by copper (II) complex.

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