4652-65-7

Basic information

• Product Name: Z-GLU(OME)-OH
• Synonyms: N-ALPHA-CARBOBENZOXY-L-GLUTAMIC ACID GAMMA-METHYL ESTER;Z-GLU(OME)-OH;Z-GLUTAMIC ACID(OME)-OH;Z-L-GLUTAMIC ACID GAMMA-METHYL ESTER;CBZ-GLU(OME)-OH;BENZYLOXYCARBONYL-L-GLUTAMIC ACID GAMMA-METHYL ESTER;Cbz-L-glutamicacid4-methylester;N-Benzyloxycarbonyl-L-glutamic acid GAMMA-methyl ester
• CAS NO: 4652-65-7
• Molecular Formula: C₁₄H₁₇NO₆
• Molecular Weight: 295.29
• Mol File: 4652-65-7.mol
• Article Data: 16

Chemical Properties

• Melting Point: 76℃
• Boiling Point: 510.6 °C at 760 mmHg
• Flash Point: 262.6 °C
• Appearance: /
• Density: 1.272 g/cm³
• Vapor Pressure: 3.01E-11mmHg at 25°C
• Refractive Index: 1.535
• Storage Temp.: -15°C
• Solubility: soluble in Methanol
• CAS DataBase Reference: Z-GLU(OME)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: Z-GLU(OME)-OH(4652-65-7)
• EPA Substance Registry System: Z-GLU(OME)-OH(4652-65-7)

Safety Data

• Hazardous Substances Data: 4652-65-7(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

Z-Glu(OMe)-OH is an inhibitor of fibrin stabilizing factor.

InChI:InChI=1/C14H17NO6/c1-20-12(16)8-7-11(13(17)18)15-14(19)21-9-10-5-3-2-4-6-10/h2-6,11H,7-9H2,1H3,(H,15,19)(H,17,18)/t11-/m0/s1

Upstream product

• 124-41-4 sodium methylate 
• 4124-76-9 N-(benzyloxycarbonyl)-L-glutamic acid anhydride 
• 67-56-1 methanol 
• 57933-83-2 Isopropenyl chloroformate 
• 1155-62-0 N-benzyloxycarbonyl-L-glutamic acid 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 1499-55-4 L-glutamic acid 5-methyl ester 
• 1499-55-4 2-Amino-pentanedioic acid 5-methyl ester 
• 501-53-1 benzyl chloroformate 
• 3077-51-8 γ-methyl L-glutamate hydrochloride 
• 56-86-0 L-glutamic acid 
• 79-22-1 methyl chloroformate 
• 67436-17-3 dimethyl (S)-N-(benzyloxycarbonyl)glutamate 
• 4124-76-9 Cbz-L-glutamic anhydride 

Downstream Products

• 121426-39-9 methyl (4S)-5-oxo-4-[[(phenylmethoxy)carbonyl]amino]-5-[(2-phenylethyl)amino]pentanoate 
• 25613-46-1 N-Carbobenzoxy-γ-methyl-L-glutaminsaeure-pentachlorphenylester 
• 14687-77-5 Z-Glu(OMe)-Gly-OBu-t 
• 39993-96-9 (S)-2-Benzyloxycarbonylamino-pentanedioic acid 5-methyl ester 1-(2,4,5-trichloro-phenyl) ester 
• 904747-95-1 N-Benzyloxycarbonyl-L-glutaminsaeure-γ-methylester-α-selenophenylester 
• 39538-31-3 methyl (4S)-4-{[(benzyloxy)carbonyl]amino}-5-[(2,5-dioxo-1-pyrrolidinyl)oxy]-5-oxopentanoate 
• 1155-62-0 N-benzyloxycarbonyl-L-glutamic acid 
• 866124-66-5 C₃₁H₄₀N₂O₇ 
• 222027-12-5 (4S)-3-(benzyloxycarbonyl)-2,2-dimethyl-4-(methoxycarbonylethyl)oxazolidine 
• 988-75-0 N-benzyloxycarbonyl-L-glutamyl-L-tyrosine 
• 1177418-14-2 C₄₈H₇₃N₇O₁₄ 
• 1177418-18-6 C₅₁H₇₁N₇O₁₄ 
• 1177418-20-0 C₂₉H₄₇N₃O₁₀ 
• 1306771-19-6 C₁₈H₂₈N₈O₆ 

Relevant articles and documents

Syntheses of Enantiopure 1,2-Ethylenediamines with Tethered Secondary Amines of the Formula H 2NCH 2CH[(CH 2) nNHMe]NH 2(n = 1-4) from α-Amino Acids: New Agents for Asymmetric Catalysis

Tris(hydrochloride) adducts of the title compounds-are prepared from the inexpensive α-amino acids H 2 N(C=O)CH 2 CH(NH 2)CO 2 H, HO(C=O)(CH 2) n ′ CH(NH 2)CO 2 H (n ′ = 1, 2), and H2 N(CH 2) 4 CH(NH 2)CO 2 H, respectively (steps/overall yield = 5/32, 7/30, 7/33, 5/38). The NH 2 group that is remote from the secondary amine is installed via BH 3 reduction of an amide [-(C=O)NR 2[ derived?-from an α-amino carboxylic acid. The MeNHCH 2 units are introduced by BH 3 reductions of alkyl carbamate [RO(C=O)NHCH 2-; R = Et, t-Bu] or amide [MeHN(C=O)-] moieties.

METHOD FOR PREPARING 3-[(3S)-7-BROMO-2-OXO-5-(PYRIDIN-2-YL)-2,3-DIHYDRO-1H-[1,4]-BENZODIAZEPIN-3-YL] PROPIONIC ACID METHYL ESTER, AND COMPOUNDS USEFUL IN THAT METHOD

The present invention relates to a method for preparing 3-[(3S)-7- bromo-2-oxo-5-(pyridin-2-yl)-2,3-dihydro-IH-[l,4]-benzodiazepin-3-yl] propionic acid methyl ester from (2-amino-5-bromo-phenyl)-pyridin-2- yl-methanone. The present invention also relates

Constrained Cyclic β,γ-Diamino Acids from Glutamic Acid: Synthesis of Both Diastereomers and Unexpected Kinetic Resolution

We describe here an efficient synthesis of both diastereomers of cyclic β,γ-diamino acids starting from l-glutamic acid, based on the Blaise reaction. We show that by changing the protecting group, we can access either the five-membered-ring lactam, which