273-75-6

Basic information

• Product Name: Thiazolo[5,4-c]pyridine
• Synonyms: Thiazolo[5,4-c]pyridine;thiazolo[4,5-c]pyridine;Pyrido[3,4-d]thiazole;[1,3]thiazolo[4,5-c]pyridine
• CAS NO: 273-75-6
• Molecular Formula: C6H4N2S
• Molecular Weight: 136.17436
• Mol File: 273-75-6.mol
• Article Data: 12

Chemical Properties

• Melting Point: 105-106 °C(Solv: ethyl ether (60-29-7))
• Boiling Point: 264.282 °C at 760 mmHg
• Flash Point: 119.296 °C
• Appearance: /
• Density: 1.369 g/cm³
• Storage Temp.: 2-8°C(protect from light)
• PKA: 1.78±0.40(Predicted)
• CAS DataBase Reference: Thiazolo[5,4-c]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: Thiazolo[5,4-c]pyridine(273-75-6)
• EPA Substance Registry System: Thiazolo[5,4-c]pyridine(273-75-6)

Safety Data

• Hazardous Substances Data: 273-75-6(Hazardous Substances Data)

Usage

General Description

Thiazolo[5,4-c]pyridine is a heterocyclic compound containing a thiazole ring fused to a pyridine ring. It is a nitrogen-containing compound and is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and materials. Thiazolo[5,4-c]pyridine derivatives have shown potential biological activities, including anti-cancer, antimicrobial, and anti-inflammatory properties. They are also used as ligands in coordination chemistry and as fluorescent probes in bioimaging. The unique structure of thiazolo[5,4-c]pyridine makes it a valuable scaffold for the synthesis of diverse compounds with various applications in the fields of medicine and materials science.

Upstream product

• 89786-57-2 2-methylthiazolo[4,5-c]pyridine 
• 89002-13-1 3-amino-4-mercaptopyridine 
• 64-18-6 formic acid 
• 139460-11-0 3-amino-4-mercaptopyridine hydrochloride 
• 139460-10-9 3-(tert-Butoxycarbonylamino)-4-mercaptopyridine 
• 13091-23-1 4-chloro-3-nitropyridine 
• 18504-84-2 3,3'-dinitro-4,4'-dipyridinyl disulfide 
• 56700-70-0 3-(tert-butoxycarbonylamino)pyridine 
• 98382-93-5 4-mercapto-3-nitropyridine 
• 38240-31-2 3-nitro-1H-pyridine-4-thione 
• 97266-26-7 [1,3]thiazolo[4,5-c]pyridine-2-carboxylic acid 

Downstream Products

• 94391-50-1 5-methyl-4,5,6,7-tetrahydrothiazolo[4,5-c]pyridine 
• 214045-73-5 thiazolo[4,5-c]pyridine-N-oxide 
• 1208988-80-0 C₆H₄N₂OS 
• 1228149-77-6 C₁₂H₇ClN₂S 
• 1228149-73-2 2-(4-fluorophenyl)thiazolo[4,5-c]pyridine 
• 116608-16-3 2-p-tolylthiazolo<4,5-c>pyridine 
• 1228149-76-5 C₁₃H₁₀N₂OS 
• 1228149-74-3 C₁₂H₇FN₂S 
• 52334-36-8 2-(2-fluoro-phenyl)-thiazolo[4,5-c]pyridine 
• 1228149-75-4 C₁₃H₇N₃S 
• 214045-74-6 4-chlorothiazolo[4,5-c]pyridine 
• 1332373-54-2 C₂₅H₂₆F₂N₆OS 
• 91813-44-4 2-phenylthiazolo<4,5-c>pyridine 
• 89786-54-9 thiazolo[4,5-c]pyridine-2-ylamine 

Relevant articles and documents

Kinase inhibitor, and preparation and application of kinase inhibitor

The invention provides a compound shown as a formula (I), or a stereoisomer, a tautomer, nitrogen oxide, metabolite, a prodrug, pharmaceutically acceptable salt or solvate of the compound, and application of the compound to preparing drugs or drug compositions for treating Pim kinase-mediated diseases.

COMPOUNDS FOR TREATMENT OF DRUG RESISTANT AND PERSISTENT TUBERCULOSIS

Described herein are compounds and compositions for treating drug resistant and persistent tuberculosis. Also described herein is a method of screening for identifiying biofilm formation inhibitors.

Syntheses of 4- and 6-substituted thiazolo[4,5-c]pyridines

A general synthetic approach to 4,6-substituted thiazole[4,5-c]pyridines, involving a novel one-pot thiol deprotection-cyclization key step, is described.