27356-30-5

Basic information

• Product Name: Benzeneacetonitrile,2-(methylthio)-
• Synonyms: Benzeneacetonitrile,2-(methylthio)-;2-(2-(methylthio)phenyl)acetonitrile
• CAS NO: 27356-30-5
• Molecular Formula: C₉H₉NS
• Molecular Weight: 163.23946
• Mol File: 27356-30-5.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzeneacetonitrile,2-(methylthio)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetonitrile,2-(methylthio)-(27356-30-5)
• EPA Substance Registry System: Benzeneacetonitrile,2-(methylthio)-(27356-30-5)

Safety Data

• Hazardous Substances Data: 27356-30-5(Hazardous Substances Data)

Usage

General Description

Benzeneacetonitrile, 2-(methylthio)- is a chemical compound with the molecular formula C9H9NS. It is a derivative of benzene and acetonitrile, with a thioether group attached to the second carbon of the acetonitrile moiety. Benzeneacetonitrile,2-(methylthio)- is commonly used in the synthesis of various pharmaceuticals and agrochemicals, as well as a precursor for the production of a wide range of organic compounds. It is also used as a solvent and intermediate in organic synthesis. Benzeneacetonitrile, 2-(methylthio)- is known to be toxic if ingested or inhaled and can cause irritation to the skin and eyes, so proper safety precautions must be taken when handling this compound.

Upstream product

• 99613-56-6 2-(2-(methylsulfinyl)phenyl)acetonitrile 
• 33384-77-9 2-(methylthio)benzyl alcohol 
• 26190-68-1 1-chloromethyl-2-methylsulfanylbenzene 
• 151-50-8 potassium cyanide 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 

Downstream Products

• 99613-56-6 2-(2-(methylsulfinyl)phenyl)acetonitrile 
• 118362-15-5 C₁₆H₁₆N₂O₂S₂ 
• 94100-13-7 5-chloro-3-(2-(methylthio)phenyl)-2,1-benzisoxazole 
• 115458-58-7 2-methylthio-4'-nitrobenzophenone 
• 115435-74-0 5-chloro-2,3-bis(2-methylthiophenyl)-2H-indole-2-carbonitrile 
• 115435-79-5 4,4'-dichloro-2,2'-bis(2-(methylthio)benzoyl)azobenzene 
• 117721-66-1 3-Methyl-2-(2-methylsulfanyl-phenyl)-butyronitrile 
• 117721-68-3 2-Isopropyl-2-(2-methylsulfanyl-phenyl)-5-oxo-pentanenitrile 
• 117721-67-2 5,5-Diethoxy-2-isopropyl-2-(2-methylsulfanyl-phenyl)-pentanenitrile 
• 1092532-43-8 1-(2-methylsulfanylphenyl)-4-oxocyclohexanecarbonitrile 
• 846-53-7 7-chloro-5-(2-methylthiophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one 
• 105278-80-6 5-chloro-2'-(methylthio)-2-(phthalimidoacetamido)benzophenone 
• 115435-88-6 8-chloro-6-(2-methylthiophenyl)-1-(methylthiomethyl)-4H-s-triazolo<4,3-a>-1,4-benzodiazepine 
• 115435-85-3 8-chloro-6-(2-methylthiophenyl)-1-methyl-4H-s-triazolo<4,3-a>-1,4-benzodiazepine 

Relevant articles and documents

Application of Sulfur Ylides in 1,2-Difunctionalization of Arynes via Insertion into a C-S σ-Bond

A novel reactivity of sulfur ylides has been demonstrated in a transition-metal-free protocol to access ortho-substituted thioanisole derivatives by insertion of arynes into a C-S σ-bond in moderate to good yields. The reaction involves the formation of C-C and C-S bonds and consecutive breaking of two C-S bonds under operationally mild reaction conditions.

DI(HETERO)ARYLCYCLOHEXANE DERIVATIVES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM

The present invention relates to di(hetero)arylcyclohexane derivatives of the formula (I), in which Ar1, Ar2, R1 and R2 have the meanings indicated in the claims. The compounds of the formula (I) are valuable pharmaceutical active compounds which inhibit ATP-sensitive potassium channels in the heart muscle and are suitable, for example, for the treatment of disorders of the cardiovascular system such as arrhythmias or a decreased contractility of the heart, such as can occur, for example, in coronary heart disease, cardiac insufficiency or cardiomyopathies. In particular, they are suitable for the prevention of sudden cardiac death. The invention furthermore relates to processes and intermediates for the preparation of the compounds of the formula (I), their use and pharmaceutical compositions comprising them.

REACTION OF 4-CHLORO-1-NITROBENZENE WITH o-SUBSTITUTED PHENYLACETONITRILES; SYNTHESIS OF 8-CHLORO-1-METHYL(AND METHYLTHIOMETHYL)-6-(2-SUBSTITUTED PHENYL)-4H-s-TRIAZOLO-1,4-BENZODIAZEPINES

Reactions of 4-chloro-1-nitrobenzene with 2-methyl-, 2-methoxy- and 2-(methylthio)phenylacetonitrile in methanolic potassium hydroxide gave mixture from which the excepted 3-aryl-5-chloro-2,1-benzisoxazoles Ia-c were isolated in addition to the 2H-indoles IIIa and IIIc and acridines VIII and IX.The 2,1-benzisoxazoles were reduced to the 2-aminobenzophenones XIIa-c which were transformed via the phthalimidoacetamido compounds XIIIa-c to 5-aryl-7-chloro-1,3-dihydro-1,4-benzodiazepine-2-ones XVa-c.Treatment with phosphorus pentasulfide led to the thiones XVIa-c which reacted in boiling butanol either with acetohydrazide or with (methylthio)acetohydrazide to give the title compounds XVIIa-c and XVIIIa-c.They showed only weak anticonvulsant, incoordinating and central depressant effects.