99613-56-6

Basic information

• Product Name: 2-(2-(methylsulfinyl)phenyl)acetonitrile
• Synonyms: 2-(2-(methylsulfinyl)phenyl)acetonitrile
• CAS NO: 99613-56-6
• Molecular Weight: 179.243
• Mol File: 99613-56-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(2-(methylsulfinyl)phenyl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-(methylsulfinyl)phenyl)acetonitrile(99613-56-6)
• EPA Substance Registry System: 2-(2-(methylsulfinyl)phenyl)acetonitrile(99613-56-6)

Safety Data

• Hazardous Substances Data: 99613-56-6(Hazardous Substances Data)

Upstream product

• 27356-30-5 2-(2-(methylthio)phenyl)acetonitrile 
• 144-86-5 N-chloro-4-methylbenzenesulfonamide 

Downstream Products

• 1259521-40-8 8-fluoro-3-(2-(methylsulfinyl)phenyl)quinolin-2-amine 
• 27356-30-5 2-(2-(methylthio)phenyl)acetonitrile 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS AND THEIR USES

Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity. The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

Electronic effect, steric hindrance, and anchimeric assistance in oxidation of sulphides. Neighbouring-group participation through Sulphur-oxygen nonbonded interaction

Using a set of sulphides o- and p-XC6H4SMe, the electronic effect, steric hindrance, and anchimeric assistance for electrophilic Cl+ addition by TsNHCI and O-transfer by NalO4 were investigated by a kinetic method. The steric effect and anchimeric assistance of the ortho-substituents were evaluated by comparing the reactivity of ortho- and para-substituted compounds (K = ko/kp). For neighbouringgroup activity the following order was obtained: CH2OH ~ CH2OMe ~ CH2CO2Me CH2CO2H ~ CH2NMe2 CH2C02 - ~ CHO CO2Me ~ CO2H COMe ~ CONH2 C02- Reaction rates show that the anchimeric assistance is governed by an S mellip; 0 or S ... N close contact developed in the transition state between oppositely polarized heteroatoms. Factors controlling neighbouringgroup participation through attractive non-bonded interactions are discussed.