27372-03-8

Basic information

• Product Name: 3-Hydroxy-2-methylbutanoic Acid
• Synonyms: 3-Hydroxy-2-Methylbutanoic Acid Ethyl Ester;3-Hydroxy-2-methylbutanoic Acid (Mixture of Diastereomers);(+/-)-ETHYL 3-HYDROXY-2-METHYLBUTYRATE
• CAS NO: 27372-03-8
• Molecular Formula: C₇H₁₄O₃
• Molecular Weight: 118.1311
• Product Categories: Aliphatics
• Mol File: 27372-03-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 215.7°C at 760 mmHg
• Flash Point: 83.8°C
• Appearance: /
• Density: 1.002g/cm³
• Vapor Pressure: 0.0316mmHg at 25°C
• Refractive Index: 1.43
• Storage Temp.: Refrigerator
• Solubility: Dichloromethane, Ethyl Acetate (Slightly), Methanol (Slightly)
• PKA: 14.51±0.20(Predicted)
• CAS DataBase Reference: 3-Hydroxy-2-methylbutanoic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Hydroxy-2-methylbutanoic Acid(27372-03-8)
• EPA Substance Registry System: 3-Hydroxy-2-methylbutanoic Acid(27372-03-8)

Safety Data

• Hazardous Substances Data: 27372-03-8(Hazardous Substances Data)

Usage

Chemical Properties

Different sources of media describe the Chemical Properties of 27372-03-8 differently. You can refer to the following data:
1. Light Yellow Oil
2. Colorless clear liquid

Uses

3-Hydroxy-2-methylbutanoic Acid Ethyl Ester_x000D_(Mixture of Diastereomers) (cas# 27372-03-8) is a compound useful in organic synthesis.

InChI:InChI=1/C7H14O3/c1-4-10-7(9)5(2)6(3)8/h5-6,8H,4H2,1-3H3

Upstream product

• 82731-69-9 2,3-epoxy-2-methyl-butyric acid ethyl ester 
• 108-05-4 vinyl acetate 
• 64-17-5 ethanol 
• 50313-58-1 2-ethoxycarbonylmethyl-oxiranecarboxylic acid ethyl ester 
• 117268-79-8 sodium phenylseleno(triethyl)borate 

Downstream Products

• 121404-73-7 (2R,3S)-(+)-ethyl-2-methyl-3-hydroxybutanoate benzylether 
• 139564-43-5 Aethyl-3-acetoxy-2-methylbutyrat 
• 27372-03-8 (3S)-3-Hydroxy-2-methylbutansaeure-ethylester 
• 1333166-66-7 C₂₀H₄₀O₂ 
• 1333167-15-9 C₂₀H₄₀O₂ 
• 780772-65-8 tert-Butyl-dimethyl-{(4E,8E)-(2R,6R,10S,11R)-2,6,10-trimethyl-11-[4-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluoro-nonyloxy)-benzyloxy]-dodeca-4,8-dienyloxy}-silane 
• 780772-61-4 tert-Butyl-dimethyl-{(4E,8E)-(2S,6R,10S,11R)-2,6,10-trimethyl-11-[4-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluoro-nonyloxy)-benzyloxy]-dodeca-4,8-dienyloxy}-silane 
• 780772-57-8 tert-Butyl-dimethyl-{(4E,8E)-(2R,6S,10S,11R)-2,6,10-trimethyl-11-[4-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluoro-nonyloxy)-benzyloxy]-dodeca-4,8-dienyloxy}-silane 
• 780772-54-5 tert-Butyl-dimethyl-{(4E,8E)-(2S,6S,10S,11R)-2,6,10-trimethyl-11-[4-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluoro-nonyloxy)-benzyloxy]-dodeca-4,8-dienyloxy}-silane 
• 780773-27-5 (1R,2S,6S,10S)-1-(1,2,6,10-tetramethyldodecyloxymethyl)-4-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluorononyloxy)benzene 
• 780773-23-1 (1R,2S,6S,10R)-1-(1,2,6,10-tetramethyldodecyloxymethyl)-4-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluorononyloxy)benzene 
• 780773-19-5 (1R,2S,6R,10S)-1-(1,2,6,10-tetramethyldodecyloxymethyl)-4-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluorononyloxy)benzene 
• 780773-16-2 (1R,2S,6R,10R)-1-(1,2,6,10-tetramethyldodecyloxymethyl)-4-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluorononyloxy)benzene 
• 780772-34-1 tert-Butyl-{(E)-(2R,6S,7R)-2,6-dimethyl-7-[4-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluoro-nonyloxy)-benzyloxy]-oct-4-enyloxy}-dimethyl-silane 

Relevant articles and documents

Hepta-, hexa-, penta-, tetra-, and trisaccharide resin glycosides from three species of Ipomoea and their antiproliferative activity on two glioma cell lines

Six new partially acylated resin glycosides were isolated from convolvulin of Ipomoea purga, Ipomoea stans, and Ipomoea murucoides (Convolvulaceae). The structures of compounds 1–6 were elucidated by a combination of NMR spectroscopy and mass spectrometry. The structure of jalapinoside B (1) consists of a hexasaccharide core bonded to an 11-hydroxytetradecanoic (convolvulinic) acid forming a macrolactone acylated by a 2-methylbutanoyl, a 3-hydroxy-2-methylbutanoyl, and a quamoclinic acid B units. Purginoic acid A (2) contains a hexasaccharide core bonded to a convolvulinic acid acylated by a 3-hydroxy-2-methylbutanoyl unit. Stansin A (4) is an ester-type heterodimer, and consists of two stansoic acid A (3) units, acylated by 2-methylbutanoic and 3-hydroxy-2-methylbutanoic acids. The site of lactonization was located at C-3 of Rhamnose, and the position for the ester linkage of the monomeric unit B on the macrolactone unit A was established as C-4 of the terminal rhamnose. Compounds 5 and 6 are glycosidic acids. Murucinic acid II (5) is composed of a pentasaccharide core bonded to an 11-hydroxyhexadecanoic (jalapinolic) acid, acylated by an acetyl unit. Stansinic acid I (6) is a tetrasaccharide core bonded to a jalapinolic acid, acylated by 2-methylbutanoyl and 3-hydroxy-2-methylbutanoyl units. Preliminary testing showed the cytotoxicity of compounds 1–6 toward OVCAR and UISO-SQC-1 cancer cell lines. In addition, compound 1 showed an antiproliferative activity on glioma C6 and RG2 tumor cell lines. Copyright

The organoselenium-mediated reduction of α,β-epoxy ketones, α,β-epoxy esters, and their congeners to β-hydroxy carbonyl compounds: Novel methodologies for the synthesis of aldols and their analogues

Novel methods for the reduction of α,β-epoxy ketones, α,β-epoxy esters (glycidic esters), and their congeners to β-hydroxy carbonyl compounds (aldols) by the use of organoselenium reagents are described. The reagents, a sodium phenylseleno(triethyl)borate complex Na[PhSeB(OEt)3] easily prepared by reduction of (PhSe)2 with NaBH4 in EtOH and benzeneselenol (PhSeH) generated in situ from the borate complex by addition of acetic acid, have been demonstrated to serve as excellent reducing agents for these transformations. The organoselenium-mediated reduction of α,β-epoxy carbonyl compounds regiospecifically occurs at the α-carbon to produce a wide variety of cyclic (intramolecular) aldols as well as acyclic (intermolecular) ones in excellent yields. Quantitative mechanistic studies have revealed that the organoselenium-mediated reduction proceeds via an α-substitution process in contrast to the common electron transfer reducing agents.