27741-65-7

Basic information

• Product Name: ACETIC ACID, 2-CYCLOBUTYLIDENE-, ETHYL ESTER
• Synonyms: ACETIC ACID, 2-CYCLOBUTYLIDENE-, ETHYL ESTER;Ethyl2-cyclobutylideneacetate;Acetic acid, cyclobutylidene-, ethyl ester;Ethyl cyclobutylideneacetate;2-Cyclobutylideneacetic acid ethyl ester;Carbethoxymethylenecyclobutane;Cyclobutylidene-acetic acid ethyl ester
• CAS NO: 27741-65-7
• Molecular Formula: C₈H₁₂O₂
• Molecular Weight: 140.181
• Mol File: 27741-65-7.mol
• Article Data: 21

Chemical Properties

• Melting Point: 21℃
• Boiling Point: 128-130℃ (2 Torr)
• Flash Point: 87.6 °C
• Appearance: /
• Density: 1.124 g/cm³
• Vapor Pressure: 0.52mmHg at 25°C
• Refractive Index: 1.56
• Storage Temp.: 2-8°C
• CAS DataBase Reference: ACETIC ACID, 2-CYCLOBUTYLIDENE-, ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: ACETIC ACID, 2-CYCLOBUTYLIDENE-, ETHYL ESTER(27741-65-7)
• EPA Substance Registry System: ACETIC ACID, 2-CYCLOBUTYLIDENE-, ETHYL ESTER(27741-65-7)

Safety Data

• Hazardous Substances Data: 27741-65-7(Hazardous Substances Data)

Usage

General Description

ACETIC ACID, 2-CYCLOBUTYLIDENE-, ETHYL ESTER is a chemical compound with the molecular formula C8H14O2. It is a colorless liquid with a fruity odor and is commonly used as a flavoring agent and solvent in the pharmaceutical and food industries. The compound is derived from acetic acid and ethyl ester, and it is known for its high solubility in organic solvents. It is also utilized in the production of various synthetic flavors and fragrances. However, it is important to handle this compound with care and follow proper safety guidelines, as it can be harmful if ingested or inhaled and may cause irritation to the skin and eyes.

InChI:InChI=1/C8H12O2/c1-2-10-8(9)6-7-4-3-5-7/h6H,2-5H2,1H3

Upstream product

• 1191-95-3 cyclobutanone 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 71032-10-5 (E)-ethyl 6-bromohex-2-enoate 

Downstream Products

• 1120-72-5 2-Methylcyclopentanone 
• 229330-47-6 2-hydroxymethyl-1-oxaspiro[2.3]hexane 
• 891188-23-1 methyl {1-[(4-hydroxy-3,5-dimethylphenyl)thio]cyclobutyl}acetate 
• 1223573-54-3 ethyl 2-(1-(benzylamino)cyclobutyl)acetate 
• 1439902-62-1 2-(1-ethylcyclobutyl)acetic acid 
• 221342-48-9 spiro[3.5]nonane-6,8-dione 
• 1431546-80-3 C₃₃H₃₅N₃O₆ 
• 1290053-86-9 (4-(3-(aminomethyl)phenyl)piperidin-1-yl)(3-(2-hydroxy-2-(1-hydroxycyclobutyl)ethoxy)phenyl)methanone 
• 2110507-78-1 ethyl 6-benzyl-6-azaspiro[3.4]octane-8-carboxylate 
• 1431546-81-4 tert-butyl N-[[3-[1-[3-[2-(1-hydroxycyclobutyl)-2-oxo-ethoxy]benzoyl]-4-piperidyl]phenyl]methyl]carbamate 
• 1431546-79-0 benzyl 3-(1-(3-(2-hydroxy-2-(1-hydroxycyclobutyl)acetamido)benzoyl)piperidin-4-yl)benzylcarbamate 
• 1431546-78-9 benzyl 3-(1-(3-(2-cyclobutylideneacetamido)benzoyl)piperidin-4-yl)benzylcarbamate 
• 1227159-94-5 ethyl {1-[4-(dibenzylamino)phenyl]cyclobutyl}acetate 

Relevant articles and documents

Synthesis method of N-(phenylsulfonyl)benzamide compound and intermediate thereof

The present invention discloses a method for synthesizing an N- (phenylsulfonyl) benzamide compound and an intermediate thereof. The method comprises a synthesis method of Compound 1, which comprises the following steps: in a solvent, in the presence of a base and palladium catalyst, compound A is coupled with Compound B as shown below in Buchwald-Hartwig to give Compound 1; wherein R isC1-C8 alkyl. The present invention for the first time provides 3 intermediate compounds required for the target compound and a method for preparing them. The use of the present invention route synthesis compound 3 has high yield, good purity, reaction raw materials are cheap and easy to obtain, and suitable for industrial production advantages.

Synthesis and Exploration of Abscisic Acid Receptor Agonists Against Dought Stress by Adding Constraint to a Tetrahydroquinoline-Based Lead Structure

New oxotetrahydroquinolinyl- and oxindolinyl sulfonamides interacting with RCAR/(PYR/PYL) receptor proteins were identified as lead structures against drought stress in crops starting from protein docking studies of a sulfonamide lead structure, followed by in-depth SAR studies. Optimized five to six step synthetic approaches via substituted amino oxo-tetrahydro-quinolines and amino oxo-indolines as essential intermediates gave access to the envisaged oxo-tetrahydroquinolinyl and oxindolinyl sulfonamides. Whilst oxo-tetrahydroquinolinyl sulfonamides with additional carbon substituents or spiro-cycloalkyl groups exhibited only low to moderate target affinities, the corresponding spiro-oxindolinyl and oxo-tetrahydroquinolinyl sulfonamides carrying optimized N-substituents revealed strong interactions with RCAR/(PYR/PYL) receptor proteins in Arabidopsis thaliana. Remarkably, the in vitro activity observed for these new compounds was on the same level as observed for the naturally occurring plant hormone in line with strong efficacy against drought stress in-vivo (canola and wheat as broad-acre crops).

Bisheterocycle substituted oxa-spiro derivative, and preparation method and medical application thereof

The invention relates to a bisheterocyclic substituted oxa-spiro derivative, and a preparation method and medical application thereof. Specifically, the invention discloses compounds of formula (I) and formula (II) or pharmaceutically acceptable salts, stereoisomers or solvates thereof, and a preparation method and application thereof. Each group in the formulas is as defined in the specificationand claims in detail.