27828-71-3

Basic information

• Product Name: 5-Hydroxynicotinic acid
• Synonyms: 5-Hydroxypyridine-3-carboxylic acid, 3-Carboxy-5-hydroxypyridine;5-Hydroxy-pyridin-3-carboxylic acid;Nicotinic acid, 5-hydroxy-;5-hydroxy-3-pyridinecarboxylicaci;5-hydroxy-nicotinicaci;3-PYRIDINECARBOXYLIC ACID, 5-HYDROXY-;5-HYDROXYNICOTINIC ACID;5-HYDROXYPYRIDINE-3-CARBOXYLIC ACID
• CAS NO: 27828-71-3
• Molecular Formula: C₆H₅NO₃
• Molecular Weight: 139.11
• EINECS: -0
• Product Categories: Nicotine Derivatives;Pharmaceuticals;blocks;Carboxes;Pyridines;Acids and Derivatives;Heterocycles;pharmacetical;Pyridine series;Carboxylic Acids;Pyridine;Organic acids;Carboxylic Acids;Aromatics;Intermediates & Fine Chemicals
• Mol File: 27828-71-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 299 °C
• Boiling Point: 519.3 °C at 760 mmHg
• Flash Point: 267.9 °C
• Appearance: /
• Density: 1.485 g/cm³
• Vapor Pressure: 1.3E-11mmHg at 25°C
• Storage Temp.: Keep Cold
• PKA: 2.08±0.10(Predicted)
• BRN: 115847
• CAS DataBase Reference: 5-Hydroxynicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Hydroxynicotinic acid(27828-71-3)
• EPA Substance Registry System: 5-Hydroxynicotinic acid(27828-71-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• RTECS: QT1757500
• HazardClass: IRRITANT
• Hazardous Substances Data: 27828-71-3(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white to yellow solid

Uses

5-Hydroxynicotinic acid is a nicotinic acid analog with potential inhibitory effect on the metabolism nicotinic acid by human platelets. Used in the investigation of the hydroxylation mechanism of the flaovoprotein 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase (MHPCO).

InChI:InChI=1/C6H5NO3/c8-5-1-4(6(9)10)2-7-3-5/h1-3,8H,(H,9,10)/p-1

Upstream product

• 24242-19-1 5-aminonicotinic acid 
• 20826-04-4 5-bromo-3-pyridinecarboxylic acid 
• 36052-25-2 5-amino-nicotinic acid methyl ester 

Downstream Products

• 1252655-89-2 tert-butyl [(5-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}pyridin-3-yl)oxy]acetate 
• 1252655-90-5 [(5-{[4-(2-tert-Butylphenyl)piperazin-1-yl]carbonyl}pyridin-3-yl)oxy]acetic acid 
• 1252658-13-1 C₂₀H₂₅N₃O₂ 
• 1612179-01-7 N-{2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl}-5-methoxypyridine-3-carboxamide 
• 1612178-95-6 N-{2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl}-5-hydroxypyridine-3-carboxamide 
• 1612178-96-7 5-hydroxy-N-{2-[4-(4-methylphenyl)piperazin-1-yl]ethyl}pyridine-3-carboxamide 
• 1612179-02-8 5-methoxy-N-{2-[4-(4-methylphenyl)piperazin-1-yl]ethyl}pyridine-3-carboxamide 
• 1612179-04-0 N-{2-[4-(4-cyanophenyl)piperazin-1-yl]ethyl}-5-methoxypyridine-3-carboxamide 
• 1610736-91-8 5-fluoro-2-(4'-hydroxy-2'-(morpholinomethyl)biphenyl-3-yloxy)-N-((1s,4s)-4-(5-hydroxynicotinamido)cyclohexyl)nicotinamide trifluoroacetic acid salt 
• 59288-40-3 ethyl 5-hydroxy-6-iodo-3-pyridinecarboxylate 
• 122535-03-9 ethyl furo[3,2-b]pyridine-6-carboxylate 
• 1093121-34-6 C₂₈H₂₇N₃O₉S₂ 
• 1093121-11-9 C₂₇H₂₅N₃O₉S₂ 
• 1093121-25-5 C₂₅H₂₂N₄O₈S₂ 

Relevant articles and documents

NEW HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS, IN PARTICULAR AS ANTI-ALZHEIMER AGENTS

The invention is related to compound which comprises at least one radical C=Y, Y being O or S, and an oxidable and non protonable nitrogen atom N wherein the distance (d) between the at least one carbon atom of the radical group C=Y and the nitrogen atom, when oxidized, is comprised between 0.3 and 0.8 nanometers. The invention is related to new heterocyclic compounds defined by formula G, their preparation, to pharmaceutical compositions comprising them and to their use as therapeutic agents, particularly in the treatment of neurodegenerative or Alzheimer disease.

5-hydroxy-3-piperidylidenemethane derivatives as spasmolytics.

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