278618-79-4

Basic information

• Product Name: (5S,5aS,8aR,9R)-9-(4-Hydroxy-3,5-dimethoxy-phenyl)-8-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5-carboxylic acid
• Synonyms: (5S,5aS,8aR,9R)-9-(4-Hydroxy-3,5-dimethoxy-phenyl)-8-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5-carboxylic acid
• CAS NO: 278618-79-4
• Molecular Weight: 428.395
• Mol File: 278618-79-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (5S,5aS,8aR,9R)-9-(4-Hydroxy-3,5-dimethoxy-phenyl)-8-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (5S,5aS,8aR,9R)-9-(4-Hydroxy-3,5-dimethoxy-phenyl)-8-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5-carboxylic acid(278618-79-4)
• EPA Substance Registry System: (5S,5aS,8aR,9R)-9-(4-Hydroxy-3,5-dimethoxy-phenyl)-8-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5-carboxylic acid(278618-79-4)

Safety Data

• Hazardous Substances Data: 278618-79-4(Hazardous Substances Data)

Upstream product

• 518-28-5 podofilox 
• 6559-91-7 4'-demethylepipodophyllotoxin 
• 290371-79-8 (5S,5aR,8aR,9R)-9-(4-Hydroxy-3,5-dimethoxy-phenyl)-8-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5-carbonitrile 

Downstream Products

• 1252007-76-3 C₂₉H₃₄N₂O₈ 
• 1252007-73-0 C₂₈H₃₂N₂O₉ 
• 1252007-79-6 C₃₄H₃₆N₂O₈ 
• 1252007-63-8 C₃₂H₃₂N₂O₉ 
• 1252007-82-1 C₃₄H₃₅NO₈ 
• 327082-16-6 C₃₀H₂₉NO₈ 
• 1252007-80-9 C₃₀H₃₀N₂O₈ 
• 1252007-81-0 C₂₆H₃₀N₂O₈ 

Relevant articles and documents

Design and synthesis of novel cytotoxic podophyllotoxin derivatives

In order to investigate the effect of different C4 linkage moieties on the cytotoxicity of podophyllotoxin derivatives, novel 4-N- and 4-C-substituted 4'-O-demethylepipodophyllotoxin derivatives were designed and synthesized. All the compounds were tested against A549 and MCF-7 tumor cells in vitro, and six compounds showed significant cytotoxicity. The most active compound 9f was superior to GL-331, and exhibited potent cytotoxicity with IC50 value at 10-7mol/L level.