28126-47-8Relevant articles and documents
Catalytic asymmetric [4 + 2] cycloadditions of ketenes and N-thioacyl imines: Alternatives for direct Mannich reactions of enolizable imines
Xu, Xuan,Wang, Kan,Nelson, Scott G.
, p. 11690 - 11691 (2008/03/13)
Asymmetric cinchona alkaloid-catalyzed ketene-N-thioacyl imine cycloadditions afford enantioenriched cis-4,5-disubstituted 1,3-thiazin-6-one heterocycles with high absolute and relative stereocontrol. These cycloadditions enable a strategy for executing catalytic asymmetric direct Mannich additions to enolizable, unactivated imines. The ketene and imine reaction components are both generated in situ from readily available acid chlorides and α-amido sulfones, respectively. Copyright
