28356-58-3

Basic information

• Product Name: 4-PYRIDYLACETIC ACID HYDROCHLORIDE
• Synonyms: Pyridine-4-acetic acid hydrochloride, 98+%;4-PYRIDYLACETIC ACID 99%;4-Pyridinylacetic acid;2-(Pyridin-4-yl)acetic acid;Pyridin-4-ylacetic acid;4-Pyridylacetic acid ,98%
• CAS NO: 28356-58-3
• Molecular Formula: C₇H₇NO₂
• Molecular Weight: 173.59692
• EINECS: 248-990-5
• Product Categories: Pyridine;Pyridines
• Mol File: 28356-58-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 139-141 C
• Boiling Point: 303.823 °C at 760 mmHg
• Flash Point: 137.548 °C
• Appearance: /
• Density: 1.246 g/cm³
• Vapor Pressure: 0.000399mmHg at 25°C
• Refractive Index: 1.557
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 3.04±0.10(Predicted)
• CAS DataBase Reference: 4-PYRIDYLACETIC ACID HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PYRIDYLACETIC ACID HYDROCHLORIDE(28356-58-3)
• EPA Substance Registry System: 4-PYRIDYLACETIC ACID HYDROCHLORIDE(28356-58-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 28356-58-3(Hazardous Substances Data)

Usage

General Description

4-Pyridylacetic acid hydrochloride is a chemical compound with the molecular formula C7H8NO2Cl. It is a salt form of 4-pyridylacetic acid, which is an intermediate in the synthesis of certain pharmaceuticals and agrochemicals. 4-PYRIDYLACETIC ACID HYDROCHLORIDE has been studied for its potential use in treating central nervous system disorders and as a dopamine receptor modulator. It is also used as a reagent in organic synthesis. 4-Pyridylacetic acid hydrochloride is typically sold as a white to off-white crystalline powder and is soluble in water and ethanol. It is important to handle this compound with care as it may be harmful if ingested or inhaled and can cause irritation to the skin and eyes.

InChI:InChI=1/C7H7NO2/c9-7(10)5-6-1-3-8-4-2-6/h1-4H,5H2,(H,9,10)

Upstream product

• 79757-20-3 pyridin-4-ylacetic acid tert-butyl ester 
• 35081-79-9 1-(morpholin-4-yl)-2-(pyridin-4-yl)ethanethione 
• 29800-89-3 methyl 4-pyridineacetate 
• 54401-85-3 pyridin-4-yl-acetic acid ethyl ester 
• 100-43-6 4-vinylpyridine 
• 1122-54-9 methyl (4-pyridyl) ketone 
• 130276-14-1 isopropyl 4-pyridylacetate 
• 133604-85-0 3,5-dimethylphenyl 4-pyridylacetate 
• 108-89-4 picoline 
• 124-38-9 carbon dioxide 

Downstream Products

• 54401-85-3 pyridin-4-yl-acetic acid ethyl ester 
• 622-26-4 4-(2-Hydroxyethyl)piperidine 
• 108-89-4 picoline 
• 29800-89-3 methyl 4-pyridineacetate 
• 941318-70-3 N-{3-[3-(2-{[3-(1,3-Oxazol-5-yl)phenyl]amino}-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2-(4-pyridinyl)acetamide 
• 1355324-28-5 C₂₈H₃₀FN₃O₂ 
• 159706-91-9 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-4-((3-pyridyl)-methyl carbonyl)-3-(R)-phenylmorpholine 
• 51052-78-9 4-piperidinylacetic acid 
• 518354-88-6 ethyl (E)-3-(3-fluorophenyl)-2-(4-pyridyl)-2-propenoate 
• 117868-22-1 1-(3,4-dimethoxy-phenethyl)-4-[(3,4-dimethoxy-phenethylcarbamoyl)-methyl]-pyridinium; iodide 
• 37969-10-1 N-(3,4-dimethoxy-phenethyl)-2-[1-(3,4-dimethoxy-phenethyl)-piperidin-4-yl]-acetamide 
• 17289-64-4 1-[1-(3,4-dimethoxy-phenethyl)-piperidin-4-ylmethyl]-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline 
• 754124-67-9 1-[1-(3,4-dimethoxy-phenethyl)-piperidin-4-ylmethyl]-6,7-dimethoxy-3,4-dihydro-isoquinoline 

Relevant articles and documents

Pyridineacetamide derivative serving as CDK inhibitor, and preparation method and application thereof

The invention belongs to the technical field of pyridineacetamide derivatives, and particularly relates to a pyridineacetamide derivative serving as a CDK inhibitor and a preparation method and application of the pyridine acetamide derivative. The pyridineacetamide derivative shows excellent CDK9/CDK7 enzyme inhibitory activity, and can be used for preparing drugs used for treating cancers, especially hematologic cancers including acute myeloid leukemia, multiple myeloma, chronic lymphocytic leukemia, follicular lymphoma and the like and solid tumors such as breast cancer, prostate cancer, ovarian cancer, hepatocellular carcinoma, pancreatic cancer, kidney cancer, stomach cancer, colorectal cancer, lung cancer and the like.

Microwave-assisted rapid hydrolysis and preparation of thioamides by Willgerodt-Kindler reaction

Aldehydes and aryl alkyl ketones were efficiently transformed to thioamides with the same number of carbon atoms via Willgerodt-Kindler reaction under microwave irradiation in solvent-free conditions. The thioamides obtained were hydrolyzed to corresponding carboxylic acids with microwave dielectric heating in one minute. Both reactions are very fast and the yields are excellent.

Enhancement of the enantioselectivity of penicillin G acylase from E. coli by 'substrate tuning'

The efficiency of penicillin G acylase catalyzed transformations is enhanced significantly with respect to reaction velocity, and in particular, stereoselectivity by appropriate 'substrate tuning', i.e. by the introduction of a nitrogen atom into the part of the substrates which is recognized by the enzyme.