28383-15-5 Usage
Uses
Diphenidine is a homeomorph of the NMDA receptor channel blocker, MK 801, that has been identified as a designer drug. The (S)- and (R)- enantiomers of diphenidine have been reported to inhibit MK 801 binding to NMDA receptors in rat brain membranes with Ki values of 0.13 and 5.25 μM, respectively. It has been studied as a neuroprotective agent for the treatment of brain injury following hypoxia. This product is intended for forensic and research applications.[Cayman Chemical]
Check Digit Verification of cas no
The CAS Registry Mumber 28383-15-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,3,8 and 3 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 28383-15:
(7*2)+(6*8)+(5*3)+(4*8)+(3*3)+(2*1)+(1*5)=125
125 % 10 = 5
So 28383-15-5 is a valid CAS Registry Number.
InChI:InChI=1/C19H23N.ClH/c1-4-10-17(11-5-1)16-19(18-12-6-2-7-13-18)20-14-8-3-9-15-20;/h1-2,4-7,10-13,19H,3,8-9,14-16H2;1H
28383-15-5Relevant articles and documents
NMDA receptor affinities of 1,2-diphenylethylamine and 1-(1,2-diphenylethyl)piperidine enantiomers and of related compounds
Berger, Michael L.,Schweifer, Anna,Rebernik, Patrick,Hammerschmidt, Friedrich
experimental part, p. 3456 - 3462 (2009/09/30)
We resolved 1,2-diphenylethylamine (DPEA) into its (S)- and (R)-enantiomer and used them as precursors for synthesis of (S)- and (R)-1-(1,2-diphenylethyl)piperidine, flexible homeomorphs of the NMDA channel blocker MK-801. We also describe the synthesis o
