28490-57-5

Basic information

• Product Name: 1-FLUORO-3-(METHOXYMETHYL)BENZENE
• Synonyms: 1-FLUORO-3-(METHOXYMETHYL)BENZENE
• CAS NO: 28490-57-5
• Molecular Formula: C₈H₉FO
• Molecular Weight: 140.15
• Mol File: 28490-57-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 149.2±15.0 °C(Predicted)
• Appearance: /
• Density: 1.055±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-FLUORO-3-(METHOXYMETHYL)BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-FLUORO-3-(METHOXYMETHYL)BENZENE(28490-57-5)
• EPA Substance Registry System: 1-FLUORO-3-(METHOXYMETHYL)BENZENE(28490-57-5)

Safety Data

• Statements: 10
• Safety Statements: 16
• RIDADR: 1993
• Hazardous Substances Data: 28490-57-5(Hazardous Substances Data)

Usage

General Description

1-Fluoro-3-(methoxymethyl)benzene, also known as fluorobenzylmethyl ether, is a chemical compound with the molecular formula C8H9FO. It is a colorless liquid with a fruity odor and is commonly used as an intermediate in the production of pharmaceuticals, agrochemicals, and organic compounds. This chemical is primarily used as a building block for the synthesis of various advanced materials and is also an important reagent in organic chemical reactions. It is considered to be a hazardous chemical and should be handled with caution due to its potential health and environmental effects.

InChI:InChI=1S/C8H9FO/c1-10-6-7-3-2-4-8(9)5-7/h2-5H,6H2,1H3

Upstream product

• 124-41-4 sodium methylate 
• 456-42-8 m-fluorobenzyl chloride 
• 352-70-5 m-Fluorotoluene 
• 456-47-3 3-fluoro-benzenemethanol 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 456-41-7 1-(Bromomethyl)-3-fluorobenzene 

Relevant articles and documents

Acid-Catalyzed Photochemical Generation of Benzyl Cations as a Probe of the Electron-Donating Abilities of Benzene Substituens in the Singlet Excited State

-

SUBSTITUTED CONDENSED THIOPHENES AS MODULATORS OF STING

A compound of formula (I), wherein: R1 is selected from (i) H, (ii) C3-6cycloalkyl, (iii) C3-7heterocyclyl optionally substituted with a group selected from: methyl and ester, and (iv) linear or branched C1-4alkyl optionally substituted with a group selected from: alkoxy, amino, amido, acylamido, acyloxy, alkyl carboxyl ester, alkyl carbamoyl, alkyl carbamoyl ester, phenyl, phosphonate ester, C3-7heterocyclyl optionally substituted with a group selected from methyl and oxo, and a naturally occurring amino acid, optionally N-substituted with a group selected from methyl, acetyl and boc; A1 is CRA or N; A2 is CRB or N; A3 is CRC or N; A4 is CRD or N; where no more than two of A1, A2, A3, and A4 may be N; one or two of RA, RB, RC, and RD, (if present) are selected from H, F, Cl, Br, Me, CF3, cyclopropyl, cyano, OMe, OEt, CH2OH, CH2OMe and CH2NMe2; the remainder of RA, RB, RC, and RD, (if present) are H; Y is O, NH or CH2; RY is selected from: (RYA) and (RYB).

Correlation of the rates of solvolysis of (arylmethyl)methylphenyl-sulfonium ions

The specific rates of solvolysis of the benzylmethylphenylsulfonium ion (prepared as the trifluoromethanesulfonate salt) and five benzylic ring-substituted derivatives can be satisfactorily correlated using NT solvent nucleophilicity values. Addition of a secondary term, governed by the aromatic ring parameter (I), shows the sensitivities towards changes in this parameter to fall and those towards changes in NT to rise with increasing electron-withdrawing ability of the substituent. The Hammett ρ values with electron-withdrawing substituents (based on ρ+ values) vary from -0.9 in 95% acetone to -1.8 in 97% 2,2,2-trifluoroethanol. These Grunwald-Winstein and Hammett analyses are compared to those previously reported, with essentially the same solvents and substituents, for solvolyses of arylmethyl p-toluenesulfonates.