285984-25-0

Basic information

• Product Name: 5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-ylamine
• Synonyms: 1H-Pyrazol-5-aMine, 3-(1,1-diMethylethyl)-1-(4-Methylphenyl)-;5-tert-butyl-2-(4-Methylphenyl)pyrazol-3-aMine;[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]amine;5-tert-butyl-2-(4-methylphenyl)-3-pyrazolamine;STK234818;ZINC02527276;BUTTPARK 74\09-04;5-TERT-BUTYL-2-P-TOLYL-2H-PYRAZOL-3-YLAMINE
• CAS NO: 285984-25-0
• Molecular Formula: C₁₄H₁₉N₃
• Molecular Weight: 229.32
• Product Categories: Chemical Synthesis;Heterocyclic Building Blocks;New Products for Chemical Synthesis;Pyrazoles;Heterocycles;Building Blocks;C12 to C37
• Mol File: 285984-25-0.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 368.271 °C at 760 mmHg
• Flash Point: 176.524 °C
• Appearance: /
• Density: 1.066 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.571
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 4.17±0.10(Predicted)
• CAS DataBase Reference: 5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-ylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-ylamine(285984-25-0)
• EPA Substance Registry System: 5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-ylamine(285984-25-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 285984-25-0(Hazardous Substances Data)

Usage

General Description

5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-ylamine is a chemical compound with the molecular formula C14H20N4. It is a derivative of pyrazole with a tert-butyl and p-tolyl group attached to the nitrogen atom. 5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-ylamine is commonly used as a reagent in organic synthesis and pharmaceutical research. It is known to exhibit pharmacological activity, particularly as a potential anti-inflammatory and analgesic agent. Additionally, it has been studied for its potential use in the treatment of neurodegenerative diseases due to its ability to modulate neurotransmission.

InChI:InChI=1/C14H19N3/c1-10-5-7-11(8-6-10)17-13(15)9-12(16-17)14(2,3)4/h5-9H,15H2,1-4H3

Upstream product

• 59997-51-2 trimethylacetylacetonitrile 
• 539-44-6 N-4-methylphenylhydrazine 
• 35467-65-3 4-methylphenylhydrazine hydrochloride 
• 637-60-5 p-tolylhydrazine hydrochloride 

Downstream Products

• 611168-87-7 carbonic acid tert-butyl ester 4-[3-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)ureido]-naphthalen-1-yl ester 
• 285984-47-6 [5-tert-butyl-2-(4-methylphenyl)-2H-pyrazol-3-yl]carbamic acid phenyl ester 
• 476010-14-7 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-(4-hydroxynaphthalen-1-yl)-urea 
• 285983-45-1 1-[5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl]-3-[4-(2-(1-oxothiomorpholin-4-yl)ethoxy)naphthalen-1-yl]-urea 
• 799294-79-4 C₃₂H₄₃N₅O₃ 
• 799283-54-8 4-{4-[3-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-ureido]-benzyl}-piperidine-1-carboxylic acid tert-butyl ester 
• 799283-66-2 C₃₄H₄₅N₅O₃ 

Relevant articles and documents

MITOGEN-ACTIVATED PROTEIN KINASE INHIBITORS, METHODS OF MAKING, AND METHODS OF USE THEREOF

Compounds that inhibit mitogen-activated protein kinases (MAPKs) are disclosed. Some inhibitor compounds specifically target a single MAPK such as MAPK13, while others target multiple MAPKs such as MAPK13 and MAPK12. The compounds can be used therapeutica

Substituted benzo pyrazole diaryl urea compound, its preparation method and medical use thereof (by machine translation)

The invention substituted benzo pyrazole diaryl urea compound, its preparation method and medical use thereof relates to a compound of formula I, or an isomer, a pharmaceutically acceptable salt and solvates; the invention also relates to the general formula I compound or its isomer, pharmaceutically acceptable salt and solvates, and a pharmaceutically acceptable carrier, excipient or diluent composition; the invention also relates to the compounds of the formula I, or an isomer, a pharmaceutically acceptable salt and solvates, used for overcoming the inflammation, inflammation-related diseases, tumor and asphyxiating gas or irritant gas caused by the use of acute lung injury; in particular with the P38 MAPK pathway-related diseases or symptoms in use. (by machine translation)

Substituted benzothiazole diaryl urea compounds, and preparation method and medical application thereof

The invention relates to compounds as shown in a general formula I which is described in the specification, or isomers, medicinal salts and solvates thereof. The invention also relates to a composition containing the compounds as shown in the general formula I or the isomers, medicinal salts and solvates thereof, and a pharmaceutically acceptable carrier, an excipient or a diluent. The invention also relates to application of the compounds as shown in the general formula I or the isomers, medicinal salts and solvates thereof to treatment of inflammations, inflammation-related diseases, tumors and acute lung injury or symptoms caused by suffocating gas or irritant gas, especially to diseases or symptoms related to a P38 MAPK pathway.