28819-30-9

Basic information

• Product Name: BENZIMIDIC ACID, HYDRAZIDE
• Synonyms: BENZIMIDIC ACID, HYDRAZIDE;BENZENECARBOXIMIDIC ACID, HYDRAZIDE;Benzimidic acid, hydrazide HCl;Benzamide hydrazone;Benzamidrazone;Benzimidic acid, hydrazide hydrochloride;benziMidohydrazide
• CAS NO: 28819-30-9
• Molecular Formula: C₇H₉N₃
• Molecular Weight: 135.17
• Product Categories: pharmacetical
• Mol File: 28819-30-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 320.5 °C at 760 mmHg
• Flash Point: 147.6 °C
• Appearance: /
• CAS DataBase Reference: BENZIMIDIC ACID, HYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: BENZIMIDIC ACID, HYDRAZIDE(28819-30-9)
• EPA Substance Registry System: BENZIMIDIC ACID, HYDRAZIDE(28819-30-9)

Safety Data

• Hazardous Substances Data: 28819-30-9(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthesis, p. 583, 1974 DOI: 10.1055/s-1974-23385

Upstream product

• 100-47-0 benzonitrile 
• 7471-86-5 methyl benzimidate 
• 2227-79-4 benzenecarbothioamide 
• 7803-57-8 hydrazine hydrate 
• 825-60-5 benzimidic acid ethyl ester 
• 55308-52-6 ethyl 3-methoxybenzimidate 
• 1670-14-0 benzamidine monohydrochloride 

Downstream Products

• 37958-25-1 3-phenyl-6,9-dioxa-1,2,4-triaza-5λ⁵-phospha-spiro[4.4]non-2-ene 
• 14157-55-2 N¹-(α-Aminobenzyliden)-3-pyridincarboxamidrazon 
• 13961-07-4 N¹-(α-Aminobenzyliden)-4-pyridincarboxamidrazon 
• 119811-39-1 3-phenyl-6-trifluoromethyl-1,2,4-triazin-5(2H)-one 
• 119811-44-8 3-pentafluoroethyl-5-phenyl-1,2,4-triazole 
• 33063-35-3 3,6-diphenyl-[1,2,4]triazine 
• 119811-45-9 C₁₀H₈F₃N₃O₂ 
• 75955-10-1 C₉H₁₁N₃ 
• 75955-10-1 C₉H₁₁N₃ 
• 33449-34-2 6-methyl-5-oxo-3-phenyl-2,5-dihydro-as-triazine 
• 75955-18-9 C₁₅H₁₅N₃ 
• 36214-25-2 5-oxo-3,6-diphenyl-2,5-dihydro-as-triazine 
• 64493-69-2 6-(4-chlorophenyl)-3-phenyl-1,2,4-triazine 
• 18039-42-4 5-Phenyl-1H-tetrazole 

Relevant articles and documents

Mechanism of generation of: Closo -decaborato amidrazones. Intramolecular non-covalent B-H?π(Ph) interaction determines stabilization of the configuration around the amidrazone CN bond

Three types of N(H)-nucleophiles, viz. hydrazine, acetyl hydrazide, and a set of hydrazones, were used to study the nucleophilic addition to the CN group of the 2-propanenitrilium closo-decaborate cluster (Ph3PCH2Ph)[B10H9NCEt], giving N-closo-decaborato amidrazones. A systematic mechanistic study of the nucleophilic addition is provided and included detailed synthetic, crystallographic, computational and kinetic work. As a result, two possible mechanisms have been proposed, which consist of firstly a consecutive incorporation of two Nu(H) nucleophiles, with the second responsible for a subsequent rapid proton exchange. The second possible mechanism assumes a pre-formation of a dinuclear [Nu(H)]2 species which subsequently proceeds with the nucleophilic attack on the boron cluster. The activation parameters for hydrazones indicate a small dependence on bond formation [ΔH? = 6.8-15 kJ mol-1], but significantly negative entropies of activation [ΔS? ranges from -139 to -164 J K-1 mol-1] with the latter contributing some 70-80% of the total Gibbs free energy of activation, ΔG?. In the X-ray structure of (Z)-(Ph3PCH2Ph)[B10H9N(H)C(Et)NHNCPh2], very rare intramolecular non-covalent B-H?π(Ph) interactions were detected and studied by DFT calculations (M06-2x/6-311++G?? level of theory) and topological analysis of the electron density distribution within the framework of Bader's theory (QTAIM method). The estimated strength of these non-covalent interactions is 0.8-1.4 kcal mol-1.

INHIBITORS OF MITOTIC KINESIN

The present invention relates to compounds useful as inhibitors of KSP and methods for the treatment or prevention of cellular proliferative diseases.

3,5-Diphenyl-1H-1,2,4-triazoles pharmaceutical compositions and uses

3,5-diphenyl-1H-1,2,4-triazoles with contragestational activity of the following formula STR1 wherein R may be located on one or the other of the two adjacent nitrogen atoms and may represent hydrogen or a group R5 CO-- wherein R5 is an aliphatic saturated or unsaturated hydrocarbyl containing from 1 to 20 carbon atoms, R1, R2 and R3, each independently are selected from hydrogen, lower alkyl and lower alkoxy or R2 and R3 together may represent a methylenedioxy group, and R4 is an aliphatic saturated or unsaturated hydrocarbyl group of from 1 to 20 carbons, with the proviso that when R is hydrogen or an R5 CO-- group wherein R5 contains 4 or less carbon atoms, R4 must contain 5 or more carbons. These compounds have proven to be highly effective in terminating pregnancy in several animal species after a single parenteral injection.