288254-71-7

Basic information

• Product Name: 3-Amino-2-(Phenylethynyl)pyridine
• Synonyms: 3-Amino-2-(Phenylethynyl)pyridine;2-(2-phenylethynyl)pyridin-3-aMine;2-(phenylethynyl)pyridin-3-amine
• CAS NO: 288254-71-7
• Molecular Formula: C₁₃H₁₀N₂
• Molecular Weight: 194.236
• Mol File: 288254-71-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 404.3 °C at 760 mmHg
• Flash Point: 227.3 °C
• Appearance: /
• Density: 1.19 g/cm³
• Vapor Pressure: 9.52E-07mmHg at 25°C
• Refractive Index: 1.66
• Storage Temp.: 2-8°C
• PKA: 3.18±0.22(Predicted)
• CAS DataBase Reference: 3-Amino-2-(Phenylethynyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-2-(Phenylethynyl)pyridine(288254-71-7)
• EPA Substance Registry System: 3-Amino-2-(Phenylethynyl)pyridine(288254-71-7)

Safety Data

• Hazardous Substances Data: 288254-71-7(Hazardous Substances Data)

Usage

General Description

3-Amino-2-(Phenylethynyl)pyridine is a chemical compound with the molecular formula C12H9N. It is a substituted pyridine derivative and belongs to the class of aminopyridines. 3-Amino-2-(Phenylethynyl)pyridine has a phenylethynyl group attached to the 2-position of the pyridine ring, as well as an amino group at the 3-position. It is commonly used as a building block in organic synthesis and pharmaceutical research due to its potential applications in the development of new drugs and materials. However, it is important to handle this compound with caution as it may pose hazards if not properly managed.

InChI:InChI=1/C13H10N2/c14-12-7-4-10-15-13(12)9-8-11-5-2-1-3-6-11/h1-7,10H,14H2

Upstream product

• 6298-19-7 2-chloro-3-aminopyridine 
• 536-74-3 phenylacetylene 
• 947330-58-7 3-nitro-2-(phenylethynyl)pyridine 
• 222167-31-9 2-(2-phenylethynyl)pyridine-3-carbaldehyde 
• 5470-18-8 2-Chloro-3-nitropyridine 

Downstream Products

• 25797-03-9 2-phenyl-1H-pyrrolo[3,2-b]pyridine 

Relevant articles and documents

Triple-Bond Directed Csp2?N Bond Formation with N-Fluorobenzenesulfonimide as Aminating Source: One-Step Transformation of Aldehydes into Amines

A metal-free, versatile triple-bond directed approach for the decarbonylative C?H amination of ortho-alkynyl quinoline/pyridine aldehydes using N-fluorobenzenesulfonimide as nitrogen source under mild reaction conditions has been described. The designed reaction strategy was triggered by trapping of fluorine by base with subsequent attack of bis(phenylsulfonyl)-λ2-azane on the carbonyl carbon of a heterocycle, which was gradually converted into the corresponding amine through a Curtius type rearrangement. This protocol provides a one-step approach for the conversion of aldehydes into amines in good yields. The synthesized amines were successfully transformed into biologically important pyrroloquinolines/pyridines.

AMIDE DERIVATIVES AND DRUGS

The present invention provides an amide derivative represented by the following formula [1]: wherein n represents 0 or 1; X represents CR4 or N; Y represents CR6 or N; Z represents CR7 or N; R1 and R2 may be the same or different and each represents hydrogen, optionally substituted alkyl, acyl, optionally substituted aryl, or an optionally substituted aromatic heterocyclic group; R4, R5, R6 and R7 may be the same or different and each represents hydrogen, halogen, hydroxy, amino, alkyl, haloalkyl, alkoxy, monoalkylamino, dialkylamino, arylalkyl, cyano, or nitro; and R3 represents optionally substituted alkylamino, optionally substituted arylamino, or optionally substituted cyclic amino, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising them as an active ingredient. The compound of the present invention is useful as a TGF-β inhibitor.