29031-19-4

Basic information

• Product Name: D-Glucosamine sulfate
• Synonyms: D-Glucosamine Sulfate Salt;DONA;2-Amino-2-deoxy-D-glucose/sulfuric acid,(1:x);D-Glucose, 2-ami;D-Glucosamine sulfat;GLUCOSAMINE SULFATE POTASSIUM CHLORIDE SALT(RG);GlucosaMine Sulphate PotassiuM Chloride;2-Amino-2-deoxy-D-glucose sulpha
• CAS NO: 29031-19-4
• Molecular Formula: 2C₆H₁₃NO₅*H₂O₄S
• Molecular Weight: 277.25
• EINECS: 249-379-6
• Product Categories: Amines;Carbohydrates & Derivatives;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;Chemical Amines
• Mol File: 29031-19-4.mol
• Article Data: 1

Chemical Properties

• Melting Point: 116 °C
• Boiling Point: 449.9 °C at 760 mmHg
• Flash Point: 225.9 °C
• Appearance: White to Off-white/Powder
• Density: 1.563 g/cm³
• Vapor Pressure: 5.53E-10mmHg at 25°C
• Storage Temp.: -20?C Freezer
• Solubility: Soluble at 1mg/ml in 1M HCl
• CAS DataBase Reference: D-Glucosamine sulfate(CAS DataBase Reference)
• NIST Chemistry Reference: D-Glucosamine sulfate(29031-19-4)
• EPA Substance Registry System: D-Glucosamine sulfate(29031-19-4)

Safety Data

• Hazardous Substances Data: 29031-19-4(Hazardous Substances Data)

Usage

Chemical Properties

White Powder

Uses

Different sources of media describe the Uses of 29031-19-4 differently. You can refer to the following data:
1. Novel application of glucosamine to prepare medical agent for treating vertigo. Found in chitin, in mucoproteins, and in mucopolysaccharides. Antiarthritic.
2. Pharmaceutic aid.
3. D-Glucosamine Sulfate is used on the syntheis of aryl β-N-acetylglucosaminides modified at C-6 as potential antimicrobial agents.

InChI:InChI=1/C6H13NO5.H2O4S/c7-3-5(10)4(9)2(1-8)12-6(3)11;1-5(2,3)4/h2-6,8-11H,1,7H2;(H2,1,2,3,4)/t2-,3-,4-,5-,6?;/m1./s1

Synthetic route

2-deoxy-2-amino glucose (90-76-6, 90-77-7, 530-23-4, 579-32-8, 579-33-9, 643-68-5, 2596-19-2, 6490-68-2, 6490-70-6, 6490-72-8, 6490-73-9, 6490-74-0, 14196-84-0, 14196-86-2, 14257-69-3, 58381-21-8) → 2-amino-2-deoxyglucose sulfate (29031-19-4)

Conditions	Yield
With sulfuric acid In water at 5 - 10℃; for 0.5h; pH=3.5; Product distribution / selectivity; polyethylene glycol homopolymer (Mw=4000);	96%
With sulfuric acid In water at 5 - 10℃; for 0.5h; pH=3.5; Product distribution / selectivity; polyethylene glycol homopolymer (Mw=8000);	96%

N-succinimidyl laurate (14565-47-0) + 2-amino-2-deoxyglucose sulfate (29031-19-4) → 2-dodecanoylamido-2-deoxy-D-glucopyranose (33600-58-7)

Conditions	Yield
With triethylamine In chloroform; dimethyl sulfoxide at 20℃; for 48h;

Upstream product

• 90-76-6 2-deoxy-2-amino glucose 

Relevant articles and documents

Halide-free glucosamine sulfate compositions and methods of preparation

Glucosamine sulfate having a purity of at least about 99 wt. %, and a maximum halide content of about 0.01 wt. %. Preferably, the glucosamine sulfate is stabilized by coating it with at least one pharmaceutically acceptable polymer comprising a water-soluble, water-immiscible and/or water-swellable homopolymer and/or copolymer. Suitable polymers include carboxypolymethylene homopolymers and copolymers; polyethylene glycol homopolymers and copolymers; polypropylene glycol homopolymers and copolymers; ethylcellulose; povidone homopolymers and copolymers; polyacrylic acid homopolymers and copolymers; polyacrylamide homopolymers and copolymers; polysaccharides; and mixtures of two or more of the foregoing polymers. The resultant coated glucosamine sulfate composition will be stable at ambient temperatures and upon exposure to the atmosphere.