29296-32-0

Basic information

• Product Name: 1,4,10,13-TETRAOXA-7,16-DIAZACYCLOOCTADECANE
• Synonyms: KRYPTOFIX(R) 22;KRYPTOFIX(R) 22 POLYMER;KRYPTOFIX 22 POLYMER;KRYPTOFIX 22;DIAZA-18-CROWN-6;4,13-DIAZA-18-CROWN-6;4,13-DIAZA-18-CROWN 6-ETHER;7,16-DIAZA-18-CROWN-6
• CAS NO: 29296-32-0
• Molecular Formula: C12H26N2O4
• Molecular Weight: 262.35
• EINECS: 245-965-0
• Mol File: 29296-32-0.mol
• Article Data: 10

Chemical Properties

• Melting Point: 111-114 °C(lit.)
• Boiling Point: 412.1°C at 760 mmHg
• Flash Point: 170.6°C
• Appearance: /
• Vapor Pressure: 5.33E-07mmHg at 25°C
• CAS DataBase Reference: 1,4,10,13-TETRAOXA-7,16-DIAZACYCLOOCTADECANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4,10,13-TETRAOXA-7,16-DIAZACYCLOOCTADECANE(29296-32-0)
• EPA Substance Registry System: 1,4,10,13-TETRAOXA-7,16-DIAZACYCLOOCTADECANE(29296-32-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 2
• RTECS: HM1650000
• F: 10
• Hazardous Substances Data: 29296-32-0(Hazardous Substances Data)

Usage

General Description

1,4,10,13-Tetraoxa-7,16-diazacyclooctadecane, also known as cyclam, is a macrocyclic compound that contains four oxygen and two nitrogen atoms in its structure. It is a versatile chemical that is widely used in various fields including coordination chemistry, materials science, and peptide chemistry. Cyclam is known for its ability to form stable complexes with metal ions, making it useful in metal extraction and separation processes. It also has applications in the development of functional materials such as molecular sieves and catalysts. Additionally, cyclam derivatives have been studied for their potential use in drug delivery and medical imaging. Overall, the unique structure and properties of 1,4,10,13-Tetraoxa-7,16-diazacyclooctadecane make it a valuable and versatile chemical in the field of chemistry and materials science.

InChI:InChI=1/C12H26N2O4/c1-5-15-9-10-17-7-3-14-4-8-18-12-11-16-6-2-13-1/h13-14H,1-12H2/p+2

Upstream product

• 53459-40-8 1-(2-chloroethyl)-4-(chloromethyl)benzene 
• 103-63-9 1-phenyl-2-bromoethane 
• 60-12-8 2-phenylethanol 
• 35793-35-2 p-chloromethyl-α-bromoethylbenzene 
• 100-41-4 ethylbenzene 
• 100-42-5 styrene 
• 107-30-2 chloromethyl methyl ether 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 73291-09-5 4-chloromethylbenzaldehyde 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 1074-61-9 (4-vinyl-phenyl)-methanol 
• 76297-21-7 1-(4-chloromethylphenyl)ethanol 
• 24249-98-7 p-chloromethyl-2-bromoethylbenzene 
• 1467-05-6 4-ethylbenzylchloride 

Downstream Products

• 82941-32-0 4-[N-methyl-N-(p-vinylbenzyl)amino]pyridine 
• 159358-34-6 diisopropyl p-vinylbenzylphosphonate 
• 15325-49-2 4-vinylbenzyl methyl sulfide 
• 1159840-52-4 (R)-1-(4-(chloromethyl)phenyl)ethane-1,2-diol 
• 1392490-22-0 (S)-1-(4-(chloromethyl)phenyl)ethane-1,2-diol 

Relevant articles and documents

Preparation method of P-chloromethyl styrene

The invention relates to the field of organic chemistry, in particular to a preparation method of p-chloromethyl styrene. The invention provides a preparation method of p-chloromethyl styrene, which comprises the following step: carrying out elimination reaction on 1-(2-chloroethyl)-4-chloromethylbenzene under alkaline conditions to prepare the p-chloromethyl styrene. According to the preparation method, the reaction raw materials with relatively low price are utilized, the manufacturing cost is reduced, the manufacturing process is simple and safe, various side reactions are less, the product conversion rate is high, the purity is high, and thus a good industrialization prospect can be realized.

Highly selective halogenation of unactivated C(sp3)-H with NaX under co-catalysis of visible light and Ag@AgX

The direct selective halogenation of unactivated C(sp3)-H bonds into C-halogen bonds was achieved using a nano Ag/AgCl catalyst at RT under visible light or LED irradiation in the presence of an aqueous solution of NaX/HX as a halide source, in air. The halogenation of hydrocarbons provided mono-halide substituted products with 95% selectivity and yields higher than 90%, with the chlorination of toluene being 81%, far higher than the 40% conversion using dichlorine. Mechanistic studies demonstrated that the reaction is a free radical process using blue light (450-500 nm), with visible light being the most effective light source. Irradiation is proposed to cause AgCl bonding electrons to become excited and electron transfer from chloride ions induces chlorine radical formation which drives the substitution reaction. The reaction provides a potentially valuable method for the direct chlorination of saturated hydrocarbons.

Aromatic cation activation: Nucleophilic substitution of alcohols and carboxylic acids

A new method for the nucleophilic substitution of alcohols and carboxylic acids using aromatic tropylium cation activation has been developed. This article reports the use of chloro tropylium chloride for the rapid generation of alkyl halides and acyl chlorides under very mild reaction conditions. It demonstrates, for the first time, the synthetic potential of tropylium cations in promoting chemical transformations.