293741-63-6

Basic information

• Product Name: 6-(2-CHLORO-PROPIONYL)-4H-BENZO[1,4]OXAZIN-3-ONE
• Synonyms: 6-(2-CHLORO-PROPIONYL)-4H-BENZO[1,4]OXAZIN-3-ONE;ASINEX-REAG BAS 01042616
• CAS NO: 293741-63-6
• Molecular Formula: C11H10ClNO3
• Molecular Weight: 239.65
• Mol File: 293741-63-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 464.9±45.0 °C(Predicted)
• Appearance: /
• Density: 1.334±0.06 g/cm3(Predicted)
• PKA: 11.94±0.20(Predicted)
• CAS DataBase Reference: 6-(2-CHLORO-PROPIONYL)-4H-BENZO[1,4]OXAZIN-3-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(2-CHLORO-PROPIONYL)-4H-BENZO[1,4]OXAZIN-3-ONE(293741-63-6)
• EPA Substance Registry System: 6-(2-CHLORO-PROPIONYL)-4H-BENZO[1,4]OXAZIN-3-ONE(293741-63-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 293741-63-6(Hazardous Substances Data)

Upstream product

• 5466-88-6 3,4-dihydro-3-oxo-2H-1,4-benzoxazine 
• 7623-09-8 2-chloropropionyl chloride 

Downstream Products

• 1454580-26-7 6-[2-fluoro-4-(4-fluorophenyl)-2-methyl-5-oxo-2,5-dihydrofuran-3-yl]-2H-1,4-benzoxazin-3(4H)-one 
• 1454580-38-1 2-(4-fluorophenyl)-N-[1-oxo-1-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)propan-2-yl]-N-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]acetamide 
• 1454580-35-8 2-(4-fluorophenyl)-N-methyl-N-[1-oxo-1-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)propan-2-yl]acetamide 
• 1454580-36-9 N-ethyl-2-(4-fluorophenyl)-N-[1-oxo-1-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)propan-2-yl]acetamide 
• 1454580-37-0 N-cyclopropyl-2-(4-fluorophenyl)-N-[1-oxo-1-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)propan-2-yl]acetamide 
• 1454580-41-6 6-[4-(4-fluorophenyl)-1,2-dimethyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl]-2H-1,4-benzoxazin-3(4H)-one 
• 1454580-42-7 6-[1-ethyl-4-(4-fluorophenyl)-2-methyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl]-2H-1,4-benzoxazin-3(4H)-one 
• 1454580-43-8 6-[1-cyclopropyl-4-(4-fluorophenyl)-2-methyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl]-2H-1,4-benzoxazin-3(4H)-one 
• 1454580-44-9 6-{4-(4-fluorophenyl)-2-methyl-5-oxo-1-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-2,5-dihydro-1H-pyrrol-3-yl}-2H-1,4-benzoxazin-3(4H)-one 
• 1454580-45-0 6-[4-(4-fluorophenyl)-1-(2-hydroxyethyl)-2-methyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl]-2H-1,4-benzoxazin-3(4H)-one 
• 1454580-25-6 6-[4-(4-fluorophenyl)-2-methyl-5-oxo-2,5-dihydrofuran-3-yl]-2H-1,4-benzoxazin-3(4H)-one 

Relevant articles and documents

Design, synthesis, and structure-activity relationships of dihydrofuran-2-one and dihydropyrrol-2-one derivatives as novel benzoxazin-3-one-based mineralocorticoid receptor antagonists

Dihydrofuran-2-one and dihydropyrrol-2-one derivatives were identified as novel, potent and selective mineralocorticoid receptor (MR) antagonists by the structure-based drug design approach utilizing the crystal structure of MR/compound complex. Introduct