2958-36-3

Basic information

• Product Name: 2-Amino-2',5-dichlorobenzophenone
• Synonyms: (2-AMINO-5-CHLOROPHENYL)(2-CHLOROPHENYL)METHANONE;2'-AMINO-5'-CHLOROBENZOYL-2-CHLOROBENZENE;2-AMINO-5-CHLORO-2'-CHLOROBENZOPHENONE;2-AMINO-2',5-DICHLOROBENZOPHENONE;LABOTEST-BB LT00080738;LORAZEPAM IMP A;LORAZEPAM IMPURITY A;IFLAB-BB F1386-0354
• CAS NO: 2958-36-3
• Molecular Formula: C₁₃H₉Cl₂NO
• Molecular Weight: 266.12
• EINECS: 220-985-2
• Product Categories: Aromatic Benzophenones & Derivatives (substituted);Benzene series;Cloxazolam;Benzophenones (for High-Performance Polymer Research);Functional Materials;Reagent for High-Performance Polymer Research;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;C13 to C14;Carbonyl Compounds;Ketones
• Mol File: 2958-36-3.mol
• Article Data: 15

Chemical Properties

• Melting Point: 87-89 °C(lit.)
• Boiling Point: 453.6 °C at 760 mmHg
• Flash Point: 228.1 °C
• Appearance: yellow to yellow-green powder
• Density: 1.3134 (rough estimate)
• Vapor Pressure: 0Pa at 25℃
• Refractive Index: 1.5490 (estimate)
• Storage Temp.: Refrigerator
• Solubility: methanol: soluble
• PKA: -0.97±0.10(Predicted)
• Water Solubility: Insoluble in water.
• BRN: 652774
• CAS DataBase Reference: 2-Amino-2',5-dichlorobenzophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-2',5-dichlorobenzophenone(2958-36-3)
• EPA Substance Registry System: 2-Amino-2',5-dichlorobenzophenone(2958-36-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-37/39-24/25-36
• WGK Germany: 3
• RTECS: DJ0200000
• TSCA: Yes
• Hazardous Substances Data: 2958-36-3(Hazardous Substances Data)

Usage

Chemical Properties

YELLOW TO YELLOW-GREEN POWDER

Uses

Different sources of media describe the Uses of 2958-36-3 differently. You can refer to the following data:
1. 2-Amino-2',5-dichlorobenzophenone is used to produce lorazepam a drug of the benzodiazepine group, used especially to treat anxiety.
2. Lorazepam Impurity A.

General Description

2-Amino-2′,5-dichlorobenzophenone can be synthesized from a precursor diazepine, Iorazepam.

Synthetic route

5-chloro-3-(2-chlorophenyl)-2,1-benzisoxazole (77792-52-0) → (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3)

Conditions	Yield
With iron; acetic acid In ethanol; water at 60 - 70℃; for 2h;	92%

2-amino-5-chlorobenzonitrile (5922-60-1) + 2-Chlorobenzeneboronic acid (3900-89-8) → (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3)

Conditions	Yield
With 5,5'-dimethyl-2,2'-bipyridine; methanesulfonic acid; palladium(II) trifluoroacetate; water In 2-methyltetrahydrofuran at 80℃; for 36h; Schlenk technique;	52%

o-chlorobenzoyl chloride (609-65-4) + 4-chloro-aniline (106-47-8) → (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3)

Conditions	Yield
(i) ZnCl2, (ii) aq. HCl, (iii) H2SO4; Multistep reaction;
With sulfuric acid; acetic acid; zinc(II) chloride 2) H2O, reflux, 18 h; Yield given. Multistep reaction;
With zinc(II) chloride at 200 - 230℃; for 3h;

N-[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-acetimidic acid ethyl ester → (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3)

Conditions	Yield
With toluene-4-sulfonic acid In xylene

lorazepam (846-49-1) → (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3)

Conditions	Yield
With hydrogenchloride for 0.5h; Heating; acid hydrolysis;
With hydroxypropyl-α-cyclodextrin In water for 0.75h; Heating;

lormetazepam (848-75-9) → (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3) + lorazepam (846-49-1)

Conditions	Yield
With hydrogenchloride multistep reaction: biotransformation, acid hydrolysis;

lormetazepam (848-75-9) → (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3) + 2',5-dichloro-2-methylaminobenzophenone (5621-86-3)

Conditions	Yield
With hydrogenchloride multistep reaction: acid hydrolysis, photolysis;

ortho-chlorobenzoic acid (118-91-2) → (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3)

Conditions	Yield
Multi-step reaction with 2 steps 1.1: SOCl2 / Heating 2.1: ZnCl2 / 2 h / 205 °C 2.2: 7- percent H2SO4 / 8 h / Heating View Scheme

2-Chlorophenylacetonitrile (2856-63-5) → (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3)

Conditions	Yield
Multi-step reaction with 2 steps 1: 12 percent / KOH, K2CO3, H2O / benzene; methanol / 2 h / Ambient temperature 2: 92 percent / Fe/AcOH / H2O; ethanol / 2 h / 60 - 70 °C View Scheme

4-chlorobenzonitrile (100-00-5) → (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3)

Conditions	Yield
Multi-step reaction with 2 steps 1: 12 percent / KOH, K2CO3, H2O / benzene; methanol / 2 h / Ambient temperature 2: 92 percent / Fe/AcOH / H2O; ethanol / 2 h / 60 - 70 °C View Scheme

tert-butyl [4-chloro-2-(2-chlorobenzoyl)phenyl]carbamate → (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3)

Conditions	Yield
With hydrogenchloride In ethanol; water Reflux;
Stage #1: tert-butyl [4-chloro-2-(2-chlorobenzoyl)phenyl]carbamate With hydrogenchloride; water In ethanol Reflux; Stage #2: With sodium hydrogencarbonate In ethanol; water pH=8;

N-(t-butoxycarbonyl)-4-chloroaniline (18437-66-6) → (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3)

Conditions	Yield
Multi-step reaction with 2 steps 1.1: tert.-butyl lithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere 1.2: 1.25 h / -40 °C / Inert atmosphere 2.1: hydrogenchloride; water / ethanol / Reflux 2.2: pH 8 View Scheme

4-chloro-aniline (106-47-8) → (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3)

Conditions	Yield
Multi-step reaction with 3 steps 1.1: N-ethyl-N,N-diisopropylamine / toluene / 20 °C 2.1: tert.-butyl lithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere 2.2: 1.25 h / -40 °C / Inert atmosphere 3.1: hydrogenchloride; water / ethanol / Reflux 3.2: pH 8 View Scheme

N-methyl-N-methyloxy-2-amino-5-chlorobenzamide (150879-48-4) + 2-bromo-1-chlorobenzene (694-80-4) → (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3)

Conditions	Yield
With n-butyllithium In tetrahydrofuran at -78℃; for 1h; Inert atmosphere;
With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere;
With n-butyllithium In tetrahydrofuran at -78℃; Inert atmosphere;

5-Chloroisatoic anhydride (4743-17-3) → (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3)

Conditions	Yield
Multi-step reaction with 2 steps 1.1: triethylamine / ethanol / 0.17 h / 20 °C 1.2: 1.5 h / Reflux 2.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere View Scheme
Multi-step reaction with 2 steps 1.1: triethylamine / ethanol; water / 0.17 h / 25 °C 1.2: 1.5 h / Reflux 2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere View Scheme

5-chloroanthranilic acid (635-21-2) → (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3)

Conditions	Yield
Multi-step reaction with 2 steps 1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere 1.2: Inert atmosphere; Reflux 2.1: n-butyllithium / tetrahydrofuran / -78 °C / Inert atmosphere View Scheme

chloroacetyl chloride (79-04-9) + (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3) → 2-chloroacetamido-2’,5-dichlorobenzophenone (14405-03-9)

Conditions	Yield
In toluene at 10 - 20℃; for 3.5h;	98.1%
With potassium carbonate In ethyl acetate at 10 - 20℃; for 1h; Cooling with ice;	96.21%
In toluene for 0.0416667h; Microwave irradiation;	88%
With N-ethyl-N,N-diisopropylamine In toluene at 10 - 20℃; for 3.5h;

dimethyl sulfate (77-78-1) + (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3) → 2',5-dichloro-2-methylaminobenzophenone (5621-86-3)

Conditions	Yield
With sodium hydroxide; tetrabutylammomium bromide In tetrahydrofuran at 60℃; for 1h;	98%
With tetrabutylammomium bromide; sodium hydroxide In tetrahydrofuran at 20℃; for 1h;

phenylacetylene (536-74-3) + (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3) → 2-phenyl-4-(2'-chlorophenyl)-6-chloroquinoline

Conditions	Yield
With propylphosphonium tetrachloroindate ionic liquid supported on nanosilica In neat (no solvent) at 110℃; for 0.583333h;	98%
With indium(III) triflate at 110℃; for 0.075h; microwave irradiation;	96%
With potassium dodeca tungstocobaltate trihydrate at 110℃; for 0.166667h; Microwave irradiation; neat (no solvent);	96%

(2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3) → (2-azido-5-chlorophenyl)(2-chlorophenyl)methanone

Conditions	Yield
Stage #1: (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone With acetic acid; sodium nitrite In water at 0℃; for 1h; Stage #2: With sodium azide In water for 1h;	98%
Stage #1: (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone With acetic acid; sodium nitrite In water at 0℃; for 1h; Inert atmosphere; Stage #2: With sodium azide In water at 0 - 20℃; Inert atmosphere;	79%
Stage #1: (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone With hydrogenchloride; sodium nitrite In water at 0℃; for 0.5h; Stage #2: With sodium azide In water at 20℃; for 4h;	46%

(2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3) + acetylacetone (123-54-6) → 1-[6-chloro-4-(2-chlorophenyl)-2-methylquinolin-3-yl]ethan-1-one

Conditions	Yield
With 1,3-dimethylimidazolium sulfate monomethyl ester; L-proline at 90℃; for 0.583333h; Knoevenagel Condensation; Green chemistry;	96%
With Nd(NO3)3*6H2O In ethanol at 20℃; Friedlander reaction;	94%
With phosphoric acid In ethanol for 12h; Reflux;	93%

cyclohexane-1,2-dione (765-87-7) + (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3) → 7-chloro-9-(2'-chlorophenyl)-2,3-dihydroacridin-4(1H)-one

Conditions	Yield
With indium(III) chloride; 1-butyl-3-methylimidazolium Tetrafluoroborate at 100℃; for 2h;	96%
With sulfuric acid; silica gel In methanol for 2h; Friedlaender Quinoline Synthesis; Reflux;	93%
With eaton’s reagent In neat (no solvent) at 90℃; for 3h;	86%

dimethylglyoxal (431-03-8) + (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3) → 2-acetyl-6-chloro-4-(2'-chlorophenyl)-quinoline

Conditions	Yield
With indium(III) triflate; 1-butyl-3-methylimidazolium Tetrafluoroborate at 100℃; for 2h; Reagent/catalyst; Temperature; Solvent; Friedlaender Quinoline Synthesis; Ionic liquid;	96%

(2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3) → 2-amino-5-chloro-α-(2'-chlorophenyl)benzyl alcohol (74067-45-1)

Conditions	Yield
With sodium tetrahydroborate In ethanol for 1.5h; Heating;	95%
With sodium tetrahydroborate In methanol for 2h; Heating / reflux;	91%
With sodium tetrahydroborate In ethanol

methyl 3-cyclopropyl-3-oxopropanoate (32249-35-7) + (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3) → 6-chloro-4-(2-chloro-phenyl)-2-cyclopropyl-quinoline-3-carboxylic acid methyl ester

Conditions	Yield
With aminosulfonic acid at 70℃; for 1h; Product distribution; Further Variations:; Solvents; Temperatures; time; Friedlander condensation;	95%
With aminosulfonic acid at 70℃; for 1h; Friedlander condensation;	95%

N-phthaloylglycine chloride (6780-38-7) + (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3) → 5,2'-dichloro-2-(phtalimidoacetamido)benzophenone

Conditions	Yield
In chloroform for 6h; Heating;	94%

2-Bromoacetyl bromide (598-21-0) + (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3) → 2-(2-bromo-acetylamino)-5,2'-dichloro-benzophenone (5504-92-7)

Conditions	Yield
With potassium carbonate In dichloromethane; water at 0℃; for 1h;	94%
In diethyl ether at 10℃; for 2h;
In acetonitrile chemoselective reaction;
With sodium carbonate In dichloromethane; water at 0℃; for 2h;

ethyl acetoacetate (141-97-9) + (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3) → ethyl 6-chloro-4-(2-chlorophenyl)-2-methyl-3-quinolinecarboxylate

Conditions	Yield
With nickel(II) oxide In ethanol for 3h; Friedlaender Quinoline Synthesis; Reflux; Green chemistry;	94%
With aminosulfonic acid at 70℃; for 1.25h; Friedlander condensation;	91%
With Nd(NO3)3*6H2O In ethanol at 20℃; Friedlander reaction;	87%

1,3-cylohexanedione (504-02-9) + (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3) → 7-chloro-9-(2'-chlorophenyl)-3,4-dihydroacridin-1(2H)-one

Conditions	Yield
With nickel(II) oxide In ethanol for 3h; Friedlaender Quinoline Synthesis; Reflux; Green chemistry;	93%
With sulfuric acid; silica gel In methanol for 2h; Friedlaender Quinoline Synthesis; Reflux;	93%
With aminosulfonic acid at 70℃; for 0.75h; Friedlander condensation;	89%

5-(trifluoromethyl)-cyclohexane-1,3-dione (124612-15-3) + (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3) → 7-chloro-9-(2-chlorophenyl)-3-(trifluoromethyl)-3,4-dihydroacridin-1(2H)-one (1052719-52-4)

Conditions	Yield
With hydrogenchloride In water at 60 - 75℃; for 0.5h;	93%

(2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3) + 4-n-methylphenylacetylene (766-97-2) → 6-chloro-4-(2-chlorophenyl)-2-(p-tolyl)quinoline (1285610-45-8)

Conditions	Yield
With potassium dodeca tungstocobaltate trihydrate at 110℃; for 0.25h; Microwave irradiation; neat (no solvent);	93%

acetone (67-64-1) + (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3) → 6-chloro-4-(2-chlorophenyl)-2-methylquinoline

Conditions	Yield
With Nafion NR50 In ethanol at 200℃; for 1h; Microwave irradiation;	93%

cyclohexanone (108-94-1) + (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3) → 7-chloro-9-(2-chlorophenyl)-1,2,3,4-tetrahydroacridine

Conditions	Yield
With o-benzenedisulfonimide at 80℃; for 4h; Friedlaender synthesis; Neat (no solvent);	92%
With 1,3,5-trichloro-2,4,6-triazine In ethanol for 0.833333h; Friedlander annulation; Heating;	82%
With metal organic framework of 1,3-bis(carboxymethyl)imidazolium barium-1 complex In neat (no solvent) at 80℃; Microwave irradiation;	81%
With silver dodecatungstophosphate In ethanol for 5.5h; Heating;	80%

(2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3) + acetylenedicarboxylic acid diethyl ester (762-21-0) → diethyl 4-(2-chlorophenyl)-6-chloroquinoline-2,3-dicarboxylate (1220115-68-3)

Conditions	Yield
With indium(III) chloride at 80℃; for 0.833333h; regioselective reaction;	92%
Stage #1: acetylenedicarboxylic acid diethyl ester With pyridine at 0 - 10℃; for 0.25h; Stage #2: (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone at 20℃; for 14h;	86%
With β‐cyclodextrin In water at 65 - 75℃; for 6h;	78%

formaldehyd (50-00-0) + (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3) → N-[4-chloro-2-(2-chlorobenzoyl)phenyl]formamide (53960-31-9)

Conditions	Yield
In toluene Reflux;	92%

1-methylcyclohexan-4-one (589-92-4) + (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3) → C20H17Cl2N

Conditions	Yield
With 1,3-bis(carboxymethyl)-1H-imidazol-3-ium chloride In neat (no solvent) at 100℃; for 16h;	92%

1-phenyl-2-tosylethanone (31378-03-7) + (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3) → 6-chloro-4-(2-chlorophenyl)-2-phenyl-3-tosylquinoline

Conditions	Yield
With toluene-4-sulfonic acid In dichloromethane at 150℃; for 1h; Microwave irradiation;	92%

(2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3) + methyl iodide (74-88-4) → 2',5-dichloro-2-methylaminobenzophenone (5621-86-3)

Conditions	Yield
With potassium hydroxide In N,N-dimethyl-formamide Ambient temperature;	91%
With potassium carbonate In N,N-dimethyl-formamide at 30℃; for 5h; Concentration; Solvent; Temperature;

1-phenyl-3-dimethylaminoprop-2-enone (1201-93-0) + (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3) → 3-((4-chloro-2-(2-chlorobenzoyl)phenyl)amino)-1-phenylprop-2-en-1-one

Conditions	Yield
With toluene-4-sulfonic acid In water at 20℃; for 0.333333h; Sonication; chemoselective reaction;	91%

n-hexan-2-one (591-78-6) + (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3) → 6-chloro-4-(2-chloro-phenyl)-2-methyl-3-propyl-quinoline

Conditions	Yield
With aminosulfonic acid at 70℃; for 1.25h; Friedlander condensation;	90%

2-chloro-benzaldehyde (89-98-5) + (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3) → C20H11Cl3N2 (1283752-29-3) + 6-chloro-2-(2-chlorophenyl)-4-(2-chlorophenyl)-1,2-dihydroquinazoline (1283752-22-6)

Conditions	Yield
With urea at 140℃; under 8175.82 Torr; for 0.0666667h; Neat (no solvent); Microwave irradiation; Closed vessel;	A n/a B 90%

3-Trifluoromethylbenzaldehyde (454-89-7) + (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3) → 6-chloro-4-(2-chlorophenyl)-2-(3-(trifluoromethyl)phenyl)quinazoline (1372890-88-4)

Conditions	Yield
With Maltose; N,N'-Dimethylurea; ammonium acetate; ammonium chloride at 90℃; for 4h;	90%

acetoacetic acid methyl ester (105-45-3) + (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3) → methyl 6-chloro-4-(2-chlorophenyl)-2-methylquinoline-3-carboxylate (1309781-28-9)

Conditions	Yield
With 1,3-bis(carboxymethyl)-1H-imidazol-3-ium chloride In neat (no solvent) at 100℃; for 16h;	90%

dimethyl acetylenedicarboxylate (762-42-5) + (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3) → dimethyl 4-(2-chlorophenyl)-6-chloroquinoline-2,3-dicarboxylate (1220115-67-2)

Conditions	Yield
With tert-butylammonium hexafluorophosphate(V); calcium(II) trifluoromethanesulfonate In neat (no solvent) at 110℃; for 4.5h; Green chemistry; regioselective reaction;	89%
With propylphosphonium tetrachloroindate ionic liquid supported on nanosilica In neat (no solvent) at 110℃; for 0.333333h;	88%
Stage #1: dimethyl acetylenedicarboxylate With pyridine at 0 - 10℃; for 0.25h; Stage #2: (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone at 20℃; for 15h;	85%
With β‐cyclodextrin In water at 65 - 75℃; for 6h;	82%

1-ethynyl-3-methoxybenzene (768-70-7) + (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3) → 6-chloro-4-(2-chlorophenyl)-2-(3-methoxyphenyl)-quinoline (1093059-25-6)

Conditions	Yield
With potassium dodeca tungstocobaltate trihydrate at 110℃; for 0.166667h; Microwave irradiation; neat (no solvent);	89%

Upstream product

• 77792-52-0 5-chloro-3-(2-chlorophenyl)-2,1-benzisoxazole 
• 118-91-2 ortho-chlorobenzoic acid 
• 100-00-5 4-chlorobenzonitrile 
• 694-80-4 2-bromo-1-chlorobenzene 
• 5922-60-1 2-amino-5-chlorobenzonitrile 
• 635-21-2 5-chloroanthranilic acid 
• 4743-17-3 5-Chloroisatoic anhydride 
• 150879-48-4 N-methyl-N-methyloxy-2-amino-5-chlorobenzamide 
• 3900-89-8 2-Chlorobenzeneboronic acid 
• 106-47-8 4-chloro-aniline 
• 18437-66-6 N-(t-butoxycarbonyl)-4-chloroaniline 
• 2856-63-5 2-Chlorophenylacetonitrile 
• 848-75-9 lormetazepam 
• 846-49-1 lorazepam 

Downstream Products

• 18434-39-4 2'-(o-Chlor-benzoyl)-3.4'-dichlor-propion-anilid 
• 50885-15-9 (2-Chloro-phenyl)-[5-chloro-2-(2,2,2-trifluoro-ethylamino)-phenyl]-methanone 
• 29176-39-4 4-chloro-2-(o-chlorobenzoyl)-N^α-(benzyloxycarbonyl)glycinanilide 
• 136280-96-1 ethyl 6-chloro-4-(2-chlorophenyl)-1,2-dihydro-2-oxo-3-quinolinecarboxylate 
• 674802-95-0 2-N-(4-aminosulfonylbenzoyl)-amino-5-chloro-2'-chloro-benzophenone 
• 28546-59-0 2-(methyl-thio)-5-(o-chlorophenyl)-7-chloro-3H-1,4-benzodiazepine 
• 2894-67-9 delorazepam 
• 2894-71-5 7-chloro-1,3-dihydro-5-(o-chlorophenyl)-2H-1,4-benzodiazepine-2-thione 

Relevant articles and documents

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Cu(I)-Catalyzed Coupling and Cycloisomerization of Diazo Compounds with Terminal Yne-Alkylidenecyclopropanes: Synthesis of Functionalized Cyclopenta[ b]naphthalene Derivatives

A Cu(I)-catalyzed coupling and cycloisomerization of diazo compounds with terminal yne-alkylidenecyclopropanes (ACPs) has been presented. This reaction starts from the formation of an allenic intermediate in the Cu(I)-catalyzed cross-coupling reaction of a diazo compound with terminal alkyne in yne-tethered ACP and then undergoes a domino cycloisomerization of a 6π-electrocyclization and cyclopropane ring-opening rearrangement to give functionalized cyclopenta[b]naphthalene derivatives in moderate to excellent yields under mild conditions.

Palladium-catalyzed direct addition of arylboronic acids to 2-aminobenzonitrile derivatives: Synthesis, biological evaluation and in silico analysis of 2-aminobenzophenones, 7-benzoyl-2-oxoindolines, and 7-benzoylindoles

A palladium-catalyzed direct addition of arylboronic acids to unprotected 2-aminobenzonitriles has been developed, leading to a wide range of 2-aminobenzophenones with moderate to excellent yields. The transformation has broad scope and high functional group tolerance. Moreover, 2-oxoindoline-7-carbonitrile and indole-7-carbonitrile were applicable to this process for the construction of 7-benzoyl-2-oxoindolines and 7-benzoylindoles, respectively. Among the compounds examined, compound 4e possessed the most potent anticancer activity against H446 and HGC-27 in vitro, with IC50 values of 0.02 μmol L-1 and 0.09 μmol L-1, respectively, while compound 4a showed the best potent anticancer activity against SGC-7901 with an IC50 value of 0.01 μmol L-1. Furthermore, we also performed in silico molecular docking calculations to investigate the interaction mode and binding affinity between the examined compounds and their tubulin target. This journal is