2975-41-9Relevant articles and documents
Synthesis of 2-indanyl urea derivatives
Takahashi,Kizu,Takaya,Maki
, p. 958 - 960 (1966)
-
Air Stable Iridium Catalysts for Direct Reductive Amination of Ketones
Polishchuk, Iuliia,Sklyaruk, Jan,Lebedev, Yury,Rueping, Magnus
supporting information, p. 5919 - 5922 (2021/03/08)
Half-sandwich iridium complexes bearing bidentate urea-phosphorus ligands were found to catalyze the direct reductive amination of aromatic and aliphatic ketones under mild conditions at 0.5 mol % loading with high selectivity towards primary amines. One of the complexes was found to be active in both the Leuckart–Wallach (NH4CO2H) type reaction as well as in the hydrogenative (H2/NH4AcO) reductive amination. The protocol with ammonium formate does not require an inert atmosphere, dry solvents, as well as additives and in contrast to previous reports takes place in hexafluoroisopropanol (HFIP) instead of methanol. Applying NH4CO2D or D2 resulted in a high degree of deuterium incorporation into the primary amine α-position.
Preparation method of indan-2-amine
-
Paragraph 0028-0033, (2019/10/01)
The invention relates to a synthetic route of indan-2-amine. 2-indanone is taken as a raw material to efficiently synthesize indan-2-amine by a one-pot method. The provided preparation method of indan-2-amine is high in yield and low in cost, is environmentally friendly, is easy to operate, and is suitable for industrialization.