2986-00-7

Basic information

• Product Name: 3-acetyl-3-chlorodihydrofuran-2(3H)-one
• Synonyms: 3-acetyl-3-chlorodihydrofuran-2(3H)-one;2-Acetyl-2-chloro-γ-butyrolactone;3-Acetyl-3-chloro-4,5-dihydro-2(3H)-furanone;3-Acetyl-3-chlorotetrahydrofuran-2-one;3-Chloro-3-acetyl-4,5-dihydrofuran-2(3H)-one;3-Chloro-3-acetyltetrahydrofuran-2-one;3-acetyl-3-chlorooxolan-2-one;3-chloro-3-ethanoyl-oxolan-2-one
• CAS NO: 2986-00-7
• Molecular Formula: C₆H₇ClO₃
• Molecular Weight: 162.57098
• EINECS: 221-050-1
• Product Categories: Miscellaneous;Heterocycles;Miscellaneous Reagents
• Mol File: 2986-00-7.mol
• Article Data: 22

Chemical Properties

• Melting Point: 2.2-3.0 °C
• Boiling Point: 306.1°Cat760mmHg
• Flash Point: 147.8°C
• Appearance: /
• Density: 1.33g/cm³
• Vapor Pressure: 0.000786mmHg at 25°C
• Refractive Index: 1.479
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 3-acetyl-3-chlorodihydrofuran-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-acetyl-3-chlorodihydrofuran-2(3H)-one(2986-00-7)
• EPA Substance Registry System: 3-acetyl-3-chlorodihydrofuran-2(3H)-one(2986-00-7)

Safety Data

• Hazardous Substances Data: 2986-00-7(Hazardous Substances Data)

Usage

Chemical Properties

Pale Brown Liquid

InChI:InChI=1/C6H7ClO3/c1-4(8)6(7)2-3-10-5(6)9/h2-3H2,1H3

Upstream product

• 517-23-7 3-acetyl-2-oxo-4,5-dihydrofuran 

Downstream Products

• 1820-94-6 2-amino-5-(2-hydroxyethyl)-4-methylthiazole 
• 31784-97-1 2-(4-methyl-2-phenylthiazol-5-yl)ethan-1-ol 
• 13045-13-1 3-chloro-3-acetylpropanol 
• 58371-98-5 3, 5-dichloro-2-pentanone 
• 13051-49-5 5-Acetoxy-3-chloropentan-2-one 
• 63141-10-6 1-(1-fluorocyclopropyl)ethanone 
• 63141-03-7 3-acetyl-3-fluorodihydrofuran-2(3H)-one 
• 137-00-8 5-hydroxyethyl-4-methylthiazole 
• 14066-76-3 4-methyl-5-(β-acetoxyethyl)-2-thiazolinethione 
• 13045-14-2 3-chloro-5-(3-chloro-2-methyl-tetrahydro-furan-2-yloxy)-pentan-2-one 

Relevant articles and documents

Preparation method of alpha-chloro-alpha acetyl-gamma-butyrolactone

The invention provides a preparation method of alpha-chloro-alpha acetyl-gamma-butyrolactone, wherein the method comprises the following steps: reacting gamma-butyrolactone, an acylation reagent and an alkaline reagent as raw materials, carrying out chlorination reaction, and carrying out after-treatment to obtain alpha-chloro-alpha acetyl-gamma-butyrolactone. According to the preparation method of alpha-chloro-alpha-acetyl-gamma-butyrolactone, introduction of an acid-binding agent in a chlorination reaction is reduced, consumption of phosphoric acid and alkali is avoided, meanwhile, a distillation purification step is omitted, the preparation process is simplified, the amount of waste salt generated in the preparation process is greatly reduced, the preparation cost is effectively reduced, the generation of industrial three wastes is reduced, and a product with relatively high purity and yield is also prepared.

Differences in the efficiency of 3-deazathiamine and oxythiamine pyrophosphates as inhibitors of pyruvate dehydrogenase complex and growth of HeLa cells in?vitro

Oxythiamine (OT) and 3-deazathiamine (DAT) are the antimetabolites of thiamine. The aim of study was to compare the effects of OT and DAT pyrophosphates (-PP) on the kinetics of mammalian pyruvate dehydrogenase complex (PDHC) and the in?vitro culture of HeLa cells. The kinetic study showed that 3-deazathiamine pyrophosphate (DATPP) was a much stronger competitive inhibitor (Ki = 0.0026 μM) of PDHC than OTPP (Ki = 0.025 μM). Both Ki values were much lower versus K m for thiamine pyrophosphate (0.06 μM). However, DATPP added to the culture medium for the HeLa cells culture did not hamper the rate of cell growth and showed not significant impact on the viability of the cells, whereas OTPP and OT showed a significant cytostatic effect. The differences between the thiamine antivitamins in their effect on cell growth in?vitro may be due to differences in physicochemical properties and difficulty in DAT transport across the cell membrane.

Fully continuous flow preparation method of 3-chloro-4-amyl oxoacetate

The invention belongs to the technical field of organic chemical engineering, and particularly relates to a fully continuous flow preparation method of 3-chloro-4-amyl oxoacetate. The method comprises the following steps of simultaneously conveying chlorine and a reaction solution of acetyl butyrolactone into a micro-channel reactor, and carrying out continuous chlorination reaction to obtain alpha-acetyl-alpha-chloro-gamma-butyrolactone, then continuously conveying the reaction liquid and a mixed solution of glacial acetic acid, hydrochloric acid and water to a micro-reaction system consisting of a next micro-mixer and a micro-channel reactor at the same time, and carrying out continuous acylation reaction to obtain 3-chloro-4-amyl oxoacetate finally, acquiring a final product in a micro-channel system of continuous quenching and continuous extraction separation. Compared with a traditional intermittent kettle type synthesis method, the method disclosed by the invention is short in reaction time, high in product yield, high in automation degree, high in process continuous efficiency, high in space-time yield, low in energy consumption and easy to industrially amplify and apply.