58371-98-5Relevant articles and documents
Synthesis method for preparing 3,5-dichloro-2-pentanone from methyl acetoacetate
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Paragraph 0023-0024; 0029-0032; 0037-0040; 0045-0048; 0053, (2020/10/30)
The invention discloses a synthesis method for preparing 3,5-dichloro-2-pentanone from methyl acetoacetate. The method comprises the following steps: S1: reactor preparation: preparing two reactors, namely a first reactor and a second reactor; S2, reactor cleaning: putting the first reactor and the second reactor into clear water for cleaning, flushing the first reactor and the second reactor after cleaning is completed, and drying the first reactor and the second reactor after flushing is completed; and S3, hydrolysis for salt formation: adding methyl acetoacetate into the first reactor, dropwise adding 30% caustic soda liquid under cooling of circulating water, and continuing to conducting a reaction for 6 hours after dropwise adding so as to obtain a hydrolyzed material. According to the synthesis method for preparing 3,5-dichloro-2-pentanone from methyl acetoacetate, working steps are rigorous, flammable and explosive materials are prevented from being used, safety is improved, reaction operations are reduced, reaction efficiency is improved, and cost is effectively reduced.
A process for preparing 3, 5 - dichloro -2 - pentanone continuous flow method (by machine translation)
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Paragraph 0008; 0024-0041, (2019/11/04)
The invention relates to a process for preparing 3, 5 - dichloro - 2 - pentanone continuous-flow method, in continuous flow reaction device, through the metering of the reservoir tanks will be α - acetyl - α - chloro - γ - butyrolactone and hydrochloric acid is pumped into the reaction in the device, in the 50 - 90 °C under continuous reaction to obtain 3, 5 - dichloro - 2 - pentanone. The technical scheme of the present invention with compared with traditional kettle reaction method, avoiding the product and acid long-term contact, product with short residence time, does not produce by-products and tar, with operation and after treatment is simple, the product yield and advantage of having high purity. (by machine translation)
Synthetic method of midbody 3,5-dichloro-2-pentanone
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Paragraph 0007; 0021; 0022; 0023; 0024; 0027, (2018/11/03)
The invention discloses a synthetic method of midoby 3,5-dichloro-2-pentanone. The synthetic method adopts alpha-acetyl-gamma-butyrolactone, anhydrous potassium carbonate, alpha-acetyl-alpha-chloro-gamma-butyrolactone, hydrochloric acid, glacial acetic acid, Cu2O, benzidine and anhydrous THF as main raw materials, adopts alpha-acetyl-gamma-butyrolactone to be converted to the corresponding enol structure under the catalytic effect of the lewis acid-sulfonyl chloride, the chloride ions attach the alpha site of carbonyl, then protons are transferred, hydrogen protons are removed from a hydrogengroup, and then the hydrogen protons are re-arranged and converted to the carbonyl with more stable structure. When the acetic acid is used as a solvent and has certain solubility for an organic phaseand the hydrochloric acid, the reaction is easier, the reaction yield is greatly increased under the effect of a catalyst, the production process of prothioconazole is shortened, and the energy consumption is reduced.